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Tytuł pozycji:

Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts.

Tytuł :
Multiple Wnts act synergistically to induce Chk1/Grapes expression and mediate G2 arrest in Drosophila tracheoblasts.
Autorzy :
Kizhedathu A; Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Campus, Bangalore, India.; SASTRA University, Thirumalaisamudram, India.
Kunnappallil RS; Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Campus, Bangalore, India.
Bagul AV; Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Campus, Bangalore, India.
Verma P; Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Campus, Bangalore, India.
Guha A; Institute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Campus, Bangalore, India.
Pokaż więcej
Źródło :
ELife [Elife] 2020 Sep 02; Vol. 9. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
MeSH Terms :
Checkpoint Kinase 1*/genetics
Checkpoint Kinase 1*/metabolism
Drosophila Proteins*/genetics
Drosophila Proteins*/metabolism
Trachea*/cytology
Trachea*/embryology
G2 Phase/*genetics
Wnt Signaling Pathway/*genetics
Animals ; Drosophila/cytology ; Drosophila/embryology ; Wnt Proteins/genetics ; Wnt Proteins/metabolism
References :
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Grant Information :
inStem Core Grant International Department of Biotechnology , Ministry of Science and Technology; InStem Core Grant International Department of Biotechnology , Ministry of Science and Technology; inStem Core Grant International Department of Biotechnology, Ministry of Science and Technology; InStem Core Grant International Department of Biotechnology, Ministry of Science and Technology
Contributed Indexing :
Keywords: Checkpoint Kinase I*; D. melanogaster*; G2 arrest*; Wnt*; cell biology*; developmental biology*; tracheoblasts*
Substance Nomenclature :
0 (Drosophila Proteins)
0 (Wnt Proteins)
0 (dpp protein, Drosophila)
EC 2.7.11.1 (Checkpoint Kinase 1)
EC 2.7.11.1 (grp protein, Drosophila)
Entry Date(s) :
Date Created: 20200903 Date Completed: 20210315 Latest Revision: 20210315
Update Code :
20210316
PubMed Central ID :
PMC7505655
DOI :
10.7554/eLife.57056
PMID :
32876044
Czasopismo naukowe
Larval tracheae of Drosophila harbour progenitors of the adult tracheal system (tracheoblasts). Thoracic tracheoblasts are arrested in the G2 phase of the cell cycle in an ATR (mei-41)-Checkpoint Kinase1 (grapes, Chk1) dependent manner prior to mitotic re-entry. Here we investigate developmental regulation of Chk1 activation. We report that Wnt signaling is high in tracheoblasts and this is necessary for high levels of activated (phosphorylated) Chk1. We find that canonical Wnt signaling facilitates this by transcriptional upregulation of Chk1 expression in cells that have ATR kinase activity. Wnt signaling is dependent on four Wnts (Wg, Wnt5, 6,10) that are expressed at high levels in arrested tracheoblasts and are downregulated at mitotic re-entry. Interestingly, none of the Wnts are dispensable and act synergistically to induce Chk1. Finally, we show that downregulation of Wnt signaling and Chk1 expression leads to mitotic re-entry and the concomitant upregulation of Dpp signaling, driving tracheoblast proliferation.
(© 2020, Kizhedathu et al.)

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