Associations Between Neurochemistry and Gait Performance Following Concussion in Collegiate Athletes.

Szczegóły
Abstrakt

Tytuł:: Associations Between Neurochemistry and Gait Performance Following Concussion in Collegiate Athletes.
Autorzy:: Charney MF; Departments of Radiology (Mss Charney and Liao, Mr Starr, and Drs Coello, Breedlove, and Lin) and Psychiatry (Dr Koerte), Brigham and Women's Hospital, Boston, Massachusetts; Sports Medicine Center, Children's Hospital Colorado, Aurora (Dr Howell); Department of Orthopedics, University of Colorado School of Medicine, Aurora (Dr Howell); The Micheli Center for Sports Injury Prevention, Waltham, Massachusetts (Drs Howell and Meehan and Mr Lanois); Division of Sports Medicine, Boston Children's Hospital, Boston, Massachusetts (Mr Lanois and Dr Meehan); and Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, Ludwig-Maximilians-Universität, Munich, Germany (Dr Koerte).
Howell DR
Lanois C
Starr TC
Liao H
Coello E
Breedlove KM
Meehan WP 3rd
Koerte I
Lin AP
Źródło:: The Journal of head trauma rehabilitation [J Head Trauma Rehabil] 2020 Sep/Oct; Vol. 35 (5), pp. 342-353.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Gaithersburg Md : Aspen Publications
Original Publication: [Gaithersburg, Md.] : Aspen, [c1986-
MeSH Terms:: Athletic Injuries*/complications
Athletic Injuries*/diagnosis
Brain Concussion*/complications
Brain Concussion*/diagnosis
Gait*
Neurochemistry*
Athletes ; Female ; Humans ; Male ; Young Adult
References:: Clin Sports Med. 2011 Jan;30(1):1-17, vii. (PMID: 21074078)
J Neuroimaging. 2017 Jan;27(1):23-28. (PMID: 27601075)
Gait Posture. 2018 May;62:157-166. (PMID: 29550695)
Med Sci Sports Exerc. 2013 Jun;45(6):1030-7. (PMID: 23274602)
Neurosci Biobehav Rev. 2016 May;64:326-45. (PMID: 26915926)
Sports Med. 2018 May;48(5):1255-1268. (PMID: 29138991)
Arch Phys Med Rehabil. 2012 Feb;93(2):293-9. (PMID: 22289240)
Brain. 2013 Mar;136(Pt 3):859-71. (PMID: 23436505)
Integr Med (Encinitas). 2014 Feb;13(1):8-12. (PMID: 26770075)
Clin J Sport Med. 2018 May;28(3):262-267. (PMID: 28742610)
Alzheimers Res Ther. 2015 Mar 15;7(1):13. (PMID: 25780390)
Brain Imaging Behav. 2020 Oct;14(5):1419-1429. (PMID: 30848432)
Front Neurol. 2018 Aug 20;9:616. (PMID: 30177905)
J Neuropsychiatry Clin Neurosci. 2002 Fall;14(4):416-23. (PMID: 12426409)
Neurology. 2010 Nov 16;75(20):1786-93. (PMID: 21079180)
NeuroRx. 2005 Apr;2(2):197-214. (PMID: 15897945)
Neurology. 2014 Feb 11;82(6):521-8. (PMID: 24401686)
Arch Phys Med Rehabil. 2013 Aug;94(8):1513-20. (PMID: 23643687)
J Neurotrauma. 2017 Dec 1;34(23):3288-3294. (PMID: 28895490)
Appl Neuropsychol. 2006;13(3):166-74. (PMID: 17361669)
Med Sci Sports Exerc. 2015 Apr;47(4):673-80. (PMID: 25100340)
Br J Sports Med. 2020 Jan;54(2):94-101. (PMID: 31331944)
Malawi Med J. 2012 Sep;24(3):69-71. (PMID: 23638278)
Hum Brain Mapp. 2018 Apr;39(4):1489-1499. (PMID: 29271016)
Arch Phys Med Rehabil. 2018 Jul;99(7):1318-1324. (PMID: 29457997)
J Appl Biomech. 2017 Feb;33(1):24-31. (PMID: 27705076)
J Neurosci. 2011 Sep 21;31(38):13442-51. (PMID: 21940437)
Brain Pathol. 2015 May;25(3):318-49. (PMID: 25904047)
J Neuroimmune Pharmacol. 2013 Jun;8(3):576-93. (PMID: 23666436)
ACS Chem Neurosci. 2016 Apr 20;7(4):470-83. (PMID: 26985861)
J Athl Train. 2017 Dec;52(12):1089-1095. (PMID: 29154694)
J Neurol. 2013 Jan;260(1):242-52. (PMID: 22886061)
J Athl Train. 2019 Apr;54(4):429-438. (PMID: 30933608)
PLoS One. 2013;8(3):e58476. (PMID: 23536796)
Surg Neurol Int. 2011;2:107. (PMID: 21886880)
J Neurotrauma. 2011 Jan;28(1):1-11. (PMID: 21054143)
Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Feb 1;1(2):116-124. (PMID: 26949749)
J Sci Med Sport. 2018 Apr;21(4):358-362. (PMID: 28919121)
Psychiatry Res. 2012 Oct 30;204(1):49-54. (PMID: 23177924)
Neuroimage. 2012 Aug 15;62(2):782-90. (PMID: 21979382)
Semin Neurol. 2012 Sep;32(4):432-53. (PMID: 23361487)
Arch Phys Med Rehabil. 2020 Jan;101(1):72-80. (PMID: 31562876)
Clin J Sport Med. 2021 Mar 1;31(2):133-138. (PMID: 30762699)
J Gerontol A Biol Sci Med Sci. 2011 Oct;66(10):1083-9. (PMID: 21719612)
J Neurotrauma. 2010 Jan;27(1):65-76. (PMID: 19761385)
AJNR Am J Neuroradiol. 2007 Feb;28(2):236-42. (PMID: 17296986)
Br J Sports Med. 2017 Jun;51(11):838-847. (PMID: 28446457)
J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):221-7. (PMID: 26392405)
Magn Reson Med. 1993 Dec;30(6):672-9. (PMID: 8139448)
Sports Med. 2018 May;48(5):1097-1115. (PMID: 29453743)
Acta Neurochir (Wien). 2012 Jan;154(1):93-103; discussion 103. (PMID: 21976236)
BMC Neurol. 2011 Aug 23;11:105. (PMID: 21861906)
J Sport Health Sci. 2016 Dec;5(4):417-423. (PMID: 30356549)
Neurology. 2012 May 1;78(18):1428-33. (PMID: 22517109)
Pol J Radiol. 2010 Oct;75(4):7-10. (PMID: 22802797)
J Cereb Blood Flow Metab. 1994 Jul;14(4):615-9. (PMID: 8014208)
Hum Brain Mapp. 2020 Jan;41(1):194-217. (PMID: 31584232)
Front Cell Neurosci. 2012 Dec 12;6:58. (PMID: 23248582)
Magn Reson Med. 1993 Oct;30(4):424-37. (PMID: 8255190)
Eur J Radiol. 2012 Mar;81(3):e223-31. (PMID: 21345628)
J Vet Sci. 2011 Sep;12(3):299-301. (PMID: 21897106)
J Neurotrauma. 2012 Sep;29(13):2297-304. (PMID: 22780855)
J Neurotrauma. 2014 Jun 1;31(11):1072-5. (PMID: 24494742)
Neurosurgery. 2008 Jun;62(6):1286-95; discussion 1295-6. (PMID: 18824995)
Neurosci Lett. 2012 Feb 10;509(1):5-8. (PMID: 22108503)
Exp Brain Res. 2014 Jun;232(6):1773-82. (PMID: 24531643)
J Sci Med Sport. 2019 May;22(5):521-525. (PMID: 30509865)
J Athl Train. 2001 Sep;36(3):228-235. (PMID: 12937489)
Brain. 2014 Jan;137(Pt 1):12-32. (PMID: 23869106)
J Neurotrauma. 2015 Sep 1;32(17):1287-93. (PMID: 25843317)
Gait Posture. 2017 May;54:284-289. (PMID: 28384609)
Grant Information:: R01 NS100952 United States NS NINDS NIH HHS; R03 HD094560 United States HD NICHD NIH HHS; R43 NS108823 United States NS NINDS NIH HHS
Entry Date(s):: Date Created: 20200904 Date Completed: 20210910 Latest Revision: 20221005
Update Code:: 20240104
PubMed Central ID:: PMC7479649
DOI:: 10.1097/HTR.0000000000000616
PMID:: 32881768
: Czasopismo naukowe

Objective: To evaluate the strength of associations between single-task and dual-task gait measures and posterior cingulate gyrus (PCG) neurochemicals in acutely concussed collegiate athletes.
Setting: Participants were recruited from an NCAA Division 1 University.
Participants: Nineteen collegiate athletes acutely (<4 days) following sports-related concussion.
Design: We acquired magnetic resonance spectroscopy (MRS) in the PCG and gait performance measurements in the participants, acutely following concussion. Linear mixed-effects models were constructed to measure the effect of gait performance, in the single- and dual-task settings, and sex on the 6 neurochemicals quantified with MRS in mmol. Correlation coefficients were also calculated to determine the direction and strength of the relationship between MRS neurochemicals and gait performance, postconcussion symptom score, and number of previous concussions.
Main Measures: Average gait speed, average cadence, N-acetyl aspartate, choline, myo-inositol, glutathione, glutamate plus glutamine, and creatine.
Results: Single-task gait speed (P = .0056) and cadence (P = .0065) had significant effects on myo-inositol concentrations in the PCG, independent of sex, in concussed collegiate athletes. Single-task cadence (P = .047) also had a significant effect on glutathione in the PCG. No significant effects were observed between dual-task gait performance and PCG neurochemistry.
Conclusions: These findings indicate that increased concentrations of neuroinflammatory markers in the PCG are associated with slower single-task gait performance within 4 days of sports-related concussion.

Informacja