-
Tytuł:
-
The association between ambient air pollution and blood lipids: A longitudinal study in Shijiazhuang, China.
-
Autorzy:
-
Zhang K; Hebei Medical University, Shijiazhuang, Hebei, China; Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China.
Wang H; Hebei Medical University, Shijiazhuang, Hebei, China.
He W; Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China.
Chen G; Department of Global Health, School of Health Sciences, Wuhan University, Wuhan, China.
Lu P; Department of Epidemiology, School of Public Health and Management, Binzhou Medical University, Yantai, Shandong, China.
Xu R; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Yu P; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Ye T; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Guo S; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Li S; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Xie Y; Department of Global Health, School of Health Sciences, Wuhan University, Wuhan, China.
Hao Z; Physical Examination Center of Hebei General Hospital, Shijiazhuang, Hebei, China.
Wang H; Hebei Medical University, Shijiazhuang, Hebei, China; Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China. Electronic address: .
Guo Y; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. Electronic address: .
-
Źródło:
-
The Science of the total environment [Sci Total Environ] 2021 Jan 15; Vol. 752, pp. 141648. Date of Electronic Publication: 2020 Aug 16.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: Amsterdam, Elsevier.
-
MeSH Terms:
-
Air Pollutants*/adverse effects
Air Pollutants*/analysis
Air Pollution*/adverse effects
Air Pollution*/analysis
Aged ; China/epidemiology ; Environmental Exposure/analysis ; Humans ; Lipids ; Longitudinal Studies ; Nitrogen Dioxide/adverse effects ; Nitrogen Dioxide/analysis ; Particulate Matter/analysis
-
Contributed Indexing:
-
Keywords: Blood lipids; Gaseous pollutants; Particulate matter
-
Substance Nomenclature:
-
0 (Air Pollutants)
0 (Lipids)
0 (Particulate Matter)
S7G510RUBH (Nitrogen Dioxide)
-
Entry Date(s):
-
Date Created: 20200905 Date Completed: 20201118 Latest Revision: 20201118
-
Update Code:
-
20240104
-
DOI:
-
10.1016/j.scitotenv.2020.141648
-
PMID:
-
32889259
-
Background: Few studies have explored the associations between ambient air pollution and blood lipid levels. This study aimed to fill this knowledge gap based on a routine health examination cohort in Shijiazhuang, China.
Methods: We included 7063 participants who took the routine health examination for 2-3 times at Hebei General Hospital from January 2016 to December 2018. Individual serum levels of cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured. Their three-month average exposure to air pollution prior to the routine health examinations was estimated using inverse distance weighted method. We used linear mixed-effects regression models to examine the associations between air pollution and levels of blood lipids while controlling for age, gender, body mass index (BMI), smoking, alcohol drinking, temperature, humidity, with a random effect for each individual.
Results: Particles with diameters ≤2.5 μm and ≤10 μm (PM 2.5 and PM 10 ), nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ) and ozone (O 3 ) were all positively associated with TC, TG, and LDL-C and negatively associated with HDL-C, in single pollutant models. Each 10 μg/m 3 increment of 3-month average PM 2.5 was associated with 0.65% [95% confidence interval (CI): 0.03%-1.28%], 0.56% (95%CI: 0.33%-0.79%) and 0.63% (95%CI: 0.35%-0.91%) increment in TG, TC, and LDL-C, and 0.91% (95%CI: 0.68%-1.13%) decrease in HDL-C. In two-pollutant models, the effects of gaseous pollutants on blood lipids were weakened, while those of PMs were strengthened. Stronger associations were presented in the elderly (≥60 years) and overweight/obese (BMI ≥ 24) participants.
Conclusions: Ambient air pollution had significantly adverse effects on blood lipid levels, especially in overweight/obese and elderly individuals.
Capsule: Significant associations between increased air pollution and worse blood lipid levels were found, especially in overweight/obese and elderly individuals.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
