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Tytuł:
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Accuracy of controlled attenuation parameter compared with ultrasound for detecting hepatic steatosis in children with severe obesity.
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Autorzy:
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Runge JH; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
van Giessen J; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Draijer LG; Department of Pediatric Gastroenterology and Nutrition, Amsterdam University Medical Centers, Location Academic Medical Center/Emma Children's Hospital, University of Amsterdam, Amsterdam, The Netherlands. .; Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centers, Location Academic Medical Center/Emma Children's Hospital, Amsterdam, The Netherlands. .; Amsterdam UMC, University of Amsterdam, Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, The Netherlands. .
Deurloo EE; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Smets AMJB; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Benninga MA; Department of Pediatric Gastroenterology and Nutrition, Amsterdam University Medical Centers, Location Academic Medical Center/Emma Children's Hospital, University of Amsterdam, Amsterdam, The Netherlands.
Koot BGP; Department of Pediatric Gastroenterology and Nutrition, Amsterdam University Medical Centers, Location Academic Medical Center/Emma Children's Hospital, University of Amsterdam, Amsterdam, The Netherlands.
Stoker J; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
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Źródło:
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European radiology [Eur Radiol] 2021 Mar; Vol. 31 (3), pp. 1588-1596. Date of Electronic Publication: 2020 Sep 10.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Berlin : Springer International, c1991-
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MeSH Terms:
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Elasticity Imaging Techniques*
Fatty Liver*/complications
Fatty Liver*/diagnostic imaging
Non-alcoholic Fatty Liver Disease*
Obesity, Morbid*
Adolescent ; Biopsy ; Child ; Humans ; Liver/diagnostic imaging ; ROC Curve ; Ultrasonography
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References:
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Hepatology. 2014 Mar;59(3):1174-97. (PMID: 24002776)
Radiology. 2018 Feb;286(2):547-556. (PMID: 28915103)
Am J Gastroenterol. 2002 Sep;97(9):2460-2. (PMID: 12358273)
J Clin Endocrinol Metab. 2006 Nov;91(11):4287-94. (PMID: 16912127)
J Hepatol. 2017 May;66(5):1022-1030. (PMID: 28039099)
Gastroenterology. 2019 May;156(6):1717-1730. (PMID: 30689971)
Hepatology. 2015 Jun;61(6):1887-95. (PMID: 25529941)
BMC Gastroenterol. 2017 May 4;17(1):61. (PMID: 28472948)
Radiology. 2012 Jan;262(1):327-34. (PMID: 22106358)
Radiology. 1983 Sep;148(3):839-43. (PMID: 6878708)
Hepatology. 2013 Dec;58(6):1930-40. (PMID: 23696515)
Clin Res Hepatol Gastroenterol. 2012 Feb;36(1):13-20. (PMID: 21920839)
J Hepatol. 2016 Jun;64(6):1388-402. (PMID: 27062661)
BMJ. 2000 May 6;320(7244):1240-3. (PMID: 10797032)
J Pediatr Gastroenterol Nutr. 2008 Oct;47(4):493-9. (PMID: 18852643)
Gastroenterology. 2015 Mar;148(3):547-55. (PMID: 25461851)
J Pediatr. 2016 Jun;173:160-164.e1. (PMID: 27039224)
J Pediatr. 2014 Apr;164(4):707-713.e3. (PMID: 24360992)
Transpl Int. 2016 Apr;29(4):418-24. (PMID: 26402655)
Hepatology. 2018 Apr;67(4):1348-1359. (PMID: 29108123)
Eur J Pediatr. 2019 Jun;178(6):863-870. (PMID: 30903305)
J Pediatr Gastroenterol Nutr. 2011 Aug;53(2):190-5. (PMID: 21788761)
Obes Rev. 2017 Sep;18(9):1050-1060. (PMID: 28544608)
World J Gastroenterol. 2016 Oct 21;22(39):8812-8819. (PMID: 27818597)
Clin Gastroenterol Hepatol. 2014 May;12(5):765-73. (PMID: 24090729)
J Gastroenterol Hepatol. 2014 Jun;29(6):1149-58. (PMID: 24476011)
Hepatology. 2018 Mar;67(3):858-872. (PMID: 29028128)
Acta Paediatr. 2006 Jul;95(7):833-7. (PMID: 16801180)
J Pediatr. 2014 Aug;165(2):319-325.e1. (PMID: 24857521)
J Hepatol. 2014 May;60(5):1026-31. (PMID: 24378529)
Arch Dis Child. 2000 Feb;82(2):107-12. (PMID: 10648362)
PLoS One. 2015 Oct 29;10(10):e0140908. (PMID: 26512983)
Acta Paediatr. 2007 Apr;96(4):542-7. (PMID: 17306008)
Dig Liver Dis. 2009 Oct;41(10):749-52. (PMID: 19362523)
Eur Radiol. 2011 Jan;21(1):87-97. (PMID: 20680289)
Curr Diab Rep. 2014 Jan;14(1):448. (PMID: 24277674)
BMC Gastroenterol. 2019 Apr 8;19(1):51. (PMID: 30961539)
Gut. 2009 Nov;58(11):1538-44. (PMID: 19625277)
Hepatology. 2017 Apr;65(4):1132-1144. (PMID: 27981615)
BMC Pediatr. 2019 Apr 15;19(1):112. (PMID: 30987634)
Swiss Med Wkly. 2019 Apr 26;149:w20077. (PMID: 31026041)
J Pediatr Gastroenterol Nutr. 2012 May;54(5):700-13. (PMID: 22395188)
Eur Radiol. 2015 Oct;25(10):2921-30. (PMID: 25916386)
Gastroenterology. 2016 Mar;150(3):626-637.e7. (PMID: 26677985)
Aliment Pharmacol Ther. 2013 Nov;38(10):1267-77. (PMID: 24117728)
Anal Cell Pathol (Amst). 2014;2014:526979. (PMID: 25763333)
Br Med J (Clin Res Ed). 1986 Jan 4;292(6512):13-5. (PMID: 3080046)
BMJ. 2015 Oct 28;351:h5527. (PMID: 26511519)
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Contributed Indexing:
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Keywords: Child; Elasticity imaging techniques; Non-alcoholic fatty liver disease; Obesity
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Entry Date(s):
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Date Created: 20200910 Date Completed: 20210414 Latest Revision: 20231110
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Update Code:
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20240105
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PubMed Central ID:
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PMC7880971
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DOI:
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10.1007/s00330-020-07245-2
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PMID:
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32910234
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Objectives: To determine the diagnostic accuracy of controlled attenuation parameter (CAP) on FibroScan ® in detecting and grading steatosis in a screening setting and perform a head-to-head comparison with conventional B-mode ultrasound.
Methods: Sixty children with severe obesity (median BMI z-score 3.37; median age 13.7 years) were evaluated. All underwent CAP and US using a standardized scoring system. Magnetic resonance spectroscopy proton density fat fraction (MRS-PDFF) was used as a reference standard.
Results: Steatosis was present in 36/60 (60%) children. The areas under the ROC (AUROC) of CAP for the detection of grade ≥ S1, ≥ S2, and ≥ S3 steatosis were 0.80 (95% CI: 0.67-0.89), 0.77 (95% CI: 0.65-0.87), and 0.79 (95% CI: 0.66-0.88), respectively. The AUROC of US for the detection of grade ≥ S1 steatosis was 0.68 (95% CI: 0.55-0.80) and not significantly different from that of CAP (p = 0.09). For detecting ≥ S1 steatosis, using the optimal cutoffs, CAP (277 dB/m) and US (US steatosis score ≥ 2) had a sensitivity of 75% and 61% and a specificity of 75% and 71%, respectively. When using echogenicity of liver parenchyma as only the scoring item, US had a sensitivity of 70% and specificity of 46% to detect ≥ S1 steatosis. The difference in specificity of CAP and US when using only echogenicity of liver parenchyma of 29% was significant (p = 0.04).
Conclusion: The overall performance of CAP is not significantly better than that of US in detecting steatosis in children with obesity, provided that the standardized scoring of US features is applied. When US is based on liver echogenicity only, CAP outperforms US in screening for any steatosis (≥ S1).
Key Points: • The areas under the ROC curves of CAP and ultrasound (US) for detecting grade ≥ S1 steatosis were 0.80 and 0.68, respectively, and were not significantly different (p = 0.09). • For detecting grade ≥ S1 steatosis in severely obese children, CAP had a sensitivity of 75% and a specificity of 75% at its optimal cutoff value of 277 dB/m. • For detecting grade ≥ S1 steatosis in clinical practice, both CAP and US can be used, provided that the standardized scoring of US images is used.
