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Tytuł:
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The modifications of a fructan from Anemarrhena asphodeloides Bunge and their antioxidant activities.
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Autorzy:
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Zhang J; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Li Z; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Zhou L; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Bao J; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China.
Xu J; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, People's Republic of China. Electronic address: .
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Źródło:
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International journal of biological macromolecules [Int J Biol Macromol] 2020 Dec 01; Vol. 164, pp. 4435-4443. Date of Electronic Publication: 2020 Sep 07.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Guildford, Eng., IPC Science and Technology Press.
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MeSH Terms:
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Anemarrhena/*chemistry
Antioxidants/*pharmacology
Fructans/*chemistry
Acetates/pharmacology ; Biphenyl Compounds ; Carbohydrate Sequence ; Free Radical Scavengers/pharmacology ; Fructans/pharmacology ; Hydroxyl Radical ; Methylation ; Microscopy, Electron, Scanning ; Picrates ; Solubility ; Spectrophotometry, Ultraviolet ; Spectroscopy, Fourier Transform Infrared ; Sulfates/chemistry
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Contributed Indexing:
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Keywords: Anemarrhena asphodeloides polysaccharides (AAP70-1); Antioxidant activities; Chemical modification
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Substance Nomenclature:
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0 (Acetates)
0 (Antioxidants)
0 (Biphenyl Compounds)
0 (Free Radical Scavengers)
0 (Fructans)
0 (Picrates)
0 (Sulfates)
3352-57-6 (Hydroxyl Radical)
5GD84Y125G (chloroacetic acid)
DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
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Entry Date(s):
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Date Created: 20200910 Date Completed: 20210406 Latest Revision: 20210406
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Update Code:
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20240105
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DOI:
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10.1016/j.ijbiomac.2020.09.024
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PMID:
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32910965
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Polysaccharide modification exerts important significance for enhancing biological activity. In the present study, a fructan (AAP70-1) extracted from Anemarrhena asphodeloides Bunge was modified by carboxymethylation and sulfation modifications to obtain carboxymethylated derivatives (CM-AAP70-1s) and a sulfated derivative (S-AAP70-1), which were prepared by the chloroacetic acid-isopropanol and the chlorosulfonic acid-pyridine methods, respectively. Physicochemical characteristics and antioxidant activities in vitro of modified derivatives were determined. The results of degree of substitution (DS) and FT-IR analysis indicated that the carboxymethylated and sulfated groups were introduced successfully. After modifications, the DS of CM-AAP70-1s varied from 0.18 to 0.52 and the molecular weights (Mw) were between 4.50 × 10 3 and 8.65 × 10 3 g/mol. The DS and Mw of S-AAP70-1 were calculated to be 0.61 and 9.76 × 10 3 g/mol, respectively. The assays of the antioxidant properties demonstrated that the modified derivatives exhibited stronger scavenging effects toward DPPH and hydroxyl radicals compared with AAP70-1. These results revealed that the chemical modifications could effectively improve the potential of polysaccharides as oxidation inhibitor.
Competing Interests: Declaration of competing interest The authors declare that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
