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Tytuł:
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Gut microbiota influence on oral bioaccessibility and intestinal transport of pesticides in Chaenomeles speciosa.
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Autorzy:
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Shi YH; School of Resource & Environment, Anhui Agricultural University, Hefei, Anhui Province 230036, China.
Xiao JJ; School of Plant Protection, Anhui Agricultural University, Hefei, Anhui Province 230036, China; Anhui Province Key Laboratory of Integrated Pest Management on Crops, Hefei, China.
Liu YY; School of Resource & Environment, Anhui Agricultural University, Hefei, Anhui Province 230036, China.
Deng YJ; School of Resource & Environment, Anhui Agricultural University, Hefei, Anhui Province 230036, China.
Feng WZ; School of Plant Protection, Anhui Agricultural University, Hefei, Anhui Province 230036, China; Anhui Province Key Laboratory of Integrated Pest Management on Crops, Hefei, China.
Wei D; School of Resource & Environment, Anhui Agricultural University, Hefei, Anhui Province 230036, China.
Liao M; School of Plant Protection, Anhui Agricultural University, Hefei, Anhui Province 230036, China; Anhui Province Key Laboratory of Integrated Pest Management on Crops, Hefei, China.
Cao HQ; School of Plant Protection, Anhui Agricultural University, Hefei, Anhui Province 230036, China; Anhui Province Key Laboratory of Integrated Pest Management on Crops, Hefei, China. Electronic address: .
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Źródło:
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Food chemistry [Food Chem] 2021 Mar 01; Vol. 339, pp. 127985. Date of Electronic Publication: 2020 Sep 05.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: Barking : Elsevier Applied Science Publishers
Original Publication: Barking, Eng., Applied Science Publishers.
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MeSH Terms:
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Gastrointestinal Microbiome/*drug effects
Intestinal Mucosa/*metabolism
Pesticides/*pharmacology
Rosaceae/*chemistry
Bacteria/metabolism ; Caco-2 Cells ; Humans ; Intestinal Mucosa/cytology ; Intestinal Mucosa/microbiology ; Lactobacillus plantarum/drug effects ; Lactobacillus plantarum/isolation & purification ; Neonicotinoids/metabolism ; Neonicotinoids/pharmacology ; Nitro Compounds/metabolism ; Nitro Compounds/pharmacology ; Organothiophosphorus Compounds/metabolism ; Organothiophosphorus Compounds/pharmacology ; Pesticides/chemistry ; Pesticides/metabolism ; Rosaceae/metabolism ; Thiamethoxam/metabolism ; Thiamethoxam/pharmacology
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Contributed Indexing:
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Keywords: Bioaccessibility; Caco-2 cell; Gut microbiota; Pesticides; Risk assessment
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Substance Nomenclature:
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0 (Neonicotinoids)
0 (Nitro Compounds)
0 (Organothiophosphorus Compounds)
0 (Pesticides)
3BN7M937V8 (imidacloprid)
6F5V775VPO (phoxim)
747IC8B487 (Thiamethoxam)
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Entry Date(s):
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Date Created: 20200913 Date Completed: 20201214 Latest Revision: 20201214
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Update Code:
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20240105
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DOI:
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10.1016/j.foodchem.2020.127985
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PMID:
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32920305
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There is limited research focusing on the effects of human gut microbiota on the oral bioaccessibility and intestinal absorption of pesticide residues in food. In the present study, we use a modified setup of the Simulator of the Human Intestinal Microbial Ecosystem for the determination of pesticide residue bioaccessibility in Chaenomeles speciosa, and a Caco-2 cell model of human intestinal absorption. Results showed that gut microbiota played a dual role based their effects on contaminant release and metabolism in the bioaccessibility assay, and Lactobacillus plantarum was one of key bacterial species in the gut microbiota that influenced pesticide stability significantly. The addition of L. plantarum to the system reduced the relative amounts (by 11.40-86.51%) of six pesticides. The interaction between the food matrix and human gut microbiota led to different absorption rates, and the barrier effects increased with an increase in incubation time.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
