-
Tytuł:
-
Alfa2-adrenoblockers attenuate the elevated plasma cholesterol, anxiety levels and restore impaired spatial memory of rats under the chronic noise exposure.
-
Autorzy:
-
Manukyan AL; Department of Medical Chemistry Yerevan State Medical University after M. Heratsi, Armenia. Electronic address: .
Grigoryan AS; Department of Pathophysiology Yerevan State Medical University after M. Heratsi, Armenia.
Hunanyan LS; Department of Medical Chemistry Yerevan State Medical University after M. Heratsi, Armenia.
Harutyunyan HA; Science Research Canter, YSMU Yerevan State Medical University M. Heratsi, Armenia. Electronic address: .
Manukyan MV; Graduate Student of Yerevan State Medical University after M. Heratsi, Armenia.
Mkrtchyan VS; Graduate Student of Yerevan State Medical University after M. Heratsi, Armenia.
Melkonyan MM; Department of Medical Chemistry Yerevan State Medical University after M. Heratsi, Armenia.
-
Źródło:
-
The Science of the total environment [Sci Total Environ] 2020 Oct 20; Vol. 740, pp. 140390. Date of Electronic Publication: 2020 Jun 20.
-
Typ publikacji:
-
Journal Article
-
Język:
-
English
-
Imprint Name(s):
-
Original Publication: Amsterdam, Elsevier.
-
MeSH Terms:
-
Anxiety*
Spatial Memory*
Animals ; Cholesterol ; Maze Learning ; Rats ; Rats, Wistar
-
Contributed Indexing:
-
Keywords: Beditin; Behavior; Lipoproteins; Locomotor activity; Mesedin; Noise-induced stress
-
Substance Nomenclature:
-
97C5T2UQ7J (Cholesterol)
-
Entry Date(s):
-
Date Created: 20200915 Date Completed: 20200916 Latest Revision: 20200916
-
Update Code:
-
20240105
-
DOI:
-
10.1016/j.scitotenv.2020.140390
-
PMID:
-
32927557
-
Noise is considered one of the environmental hazards that negatively affect health. It can cause damage to the auditory, neurological, hormonal and cardiovascular systems, in addition to impairing psychological and cognitive functions. Considering the significance of vascular disturbances and oxidative stress in the development of the aforementioned negative effects, the purpose of our investigation was to study the level of high density lipoprotein-cholesterol (HDL-Cl), low density lipoprotein-cholesterol (LDL-Cl), and total cholesterol (TCl) in plasma, in addition to the behavioral characteristics of white rats, and the effects of the α 2 -adrenoblockers beditin and mesedin to reveal their antiatherogenic effect during noise exposure. The "Open field" and "Y-maze" tests were used in order to evaluate the behavioral states of the rats. Investigations were carried out on albino rats divided into 4 groups. The 1 st group of rats served as a control. The 2 nd , 3 rd and 4 th groups were exposed to 91 dBA of noise; the duration of exposure was 8 h per day for 60 days. The 3 rd group was injected with beditin and the 4 th group with mesedin, both intraperitoneally and repeatedly. According to our results, the chronic exposure to high-volume noise leads to the increase of plasma TCl and LDL-Cl concentrations and the decrease of HDL-Cl levels, resulting in increase of the atherogenic coefficient, which is estimated to be one of the main cardiovascular disease risk factors. The "Open field" and "Y-maze" tests revealed that chronic noise exposure caused disturbances in the behavioral activity, a noise duration-dependent delay in movement and orientation, increased anxiety and deficit in the animals' spatial memory. The administration of α 2 -adrenoblockers to the noise-exposed animals had a regulatoryeffects of varying intensities, depending on the medication used and the studied parameters under the conditions of chronic acoustic stress.
Competing Interests: Declaration of competing interest The authors declare no conflict of interests.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
