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Tytuł pozycji:

Circadian GLP-1 Secretion in Mice Is Dependent on the Intestinal Microbiome for Maintenance of Diurnal Metabolic Homeostasis.

Tytuł:
Circadian GLP-1 Secretion in Mice Is Dependent on the Intestinal Microbiome for Maintenance of Diurnal Metabolic Homeostasis.
Autorzy:
Martchenko SE; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Martchenko A; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Cox BJ; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
Naismith K; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Waller A; Department of Biological Sciences, Brock University, St. Catharines, Ontario, Canada.
Gurges P; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Sweeney ME; Department of Physiology, University of Toronto, Toronto, Ontario, Canada.
Philpott DJ; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
Brubaker PL; Department of Physiology, University of Toronto, Toronto, Ontario, Canada .; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Źródło:
Diabetes [Diabetes] 2020 Dec; Vol. 69 (12), pp. 2589-2602. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Publication: Alexandria, VA : American Diabetes Association
Original Publication: [New York, American Diabetes Association]
MeSH Terms:
Circadian Rhythm*
Gastrointestinal Microbiome*
Homeostasis*
Glucagon-Like Peptide 1/*metabolism
Animals ; Dietary Carbohydrates/administration & dosage ; Dietary Fats/administration & dosage ; Female ; Gene Expression Regulation/drug effects ; Glucagon-Like Peptide 1/genetics ; Glucose/administration & dosage ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/metabolism ; Sucrose
Grant Information:
Canada CAPMC CIHR
Molecular Sequence:
figshare 10.2337/figshare.12928334
Substance Nomenclature:
0 (Dietary Carbohydrates)
0 (Dietary Fats)
57-50-1 (Sucrose)
89750-14-1 (Glucagon-Like Peptide 1)
IY9XDZ35W2 (Glucose)
Entry Date(s):
Date Created: 20200915 Date Completed: 20210126 Latest Revision: 20210126
Update Code:
20240105
DOI:
10.2337/db20-0262
PMID:
32928871
Czasopismo naukowe
The incretin glucagon-like peptide 1 (GLP-1) is secreted by the intestinal L cell upon nutrient ingestion. GLP-1 also exhibits a circadian rhythm, with highest release at the onset of the feeding period. Similarly, microbial composition and function exhibit circadian rhythmicity with fasting-feeding. The circadian pattern of GLP-1 release was found to be dependent on the oral route of glucose administration and was necessary for the rhythmic release of insulin and diurnal glycemic control in normal male and female mice. In mice fed a Western (high-fat/high-sucrose) diet for 16 weeks, GLP-1 secretion was markedly increased but arrhythmic over the 24-h day, whereas levels of the other incretin, glucose-dependent insulinotropic polypeptide, were not as profoundly affected. Furthermore, the changes in GLP-1 secretion were shown to be essential for the maintenance of normoglycemia in this obesogenic environment. Analysis of the primary L-cell transcriptome, as well as of the intestinal microbiome, also demonstrated time-of-day- and diet-dependent changes paralleling GLP-1 secretion. Finally, studies in antibiotic-induced microbial depleted and in germ-free mice with and without fecal microbial transfer, provided evidence for a role of the microbiome in diurnal GLP-1 release. In combination, these findings establish a key role for microbiome-dependent circadian GLP-1 secretion in the maintenance of 24-h metabolic homeostasis.
(© 2020 by the American Diabetes Association.)

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