Detection of gadolinium deposition in cortical bone with ultrashort echo time T <subscript>1</subscript> mapping: an ex vivo study in a rabbit model. - OpacWWW

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Tytuł:: Detection of gadolinium deposition in cortical bone with ultrashort echo time T 1 mapping: an ex vivo study in a rabbit model.
Autorzy:: Zhao K; School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China.
Li S; Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, Guangzhou, 510515, China.
Yi P; School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China.
Guo Y; School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China.
Yu Q; Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, Guangzhou, 510515, China.
Zhu C; Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, Guangzhou, 510515, China.
Feng Q; School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China.
Du J; Department of Radiology, University of California, San Diego, CA, USA.
Zhang X; Department of Medical Imaging, Third Affiliated Hospital, Southern Medical University, Guangzhou, 510515, China. .
Feng Y; School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China. .; Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China. .
Źródło:: European radiology [Eur Radiol] 2021 Mar; Vol. 31 (3), pp. 1569-1577. Date of Electronic Publication: 2020 Sep 14.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: Berlin : Springer International, c1991-
MeSH Terms:: Gadolinium*
Organometallic Compounds*
Animals ; Contrast Media ; Cortical Bone/diagnostic imaging ; Gadolinium DTPA ; Magnetic Resonance Imaging ; Male ; Rabbits
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Grant Information:: 81871349, 61671228 National Natural Science Foundation of China; 81801653 National Natural Science Foundation of China; 2018B030333001 and 2017B090912006 Science and Technology Program of Guangdong
Contributed Indexing:: Keywords: Contrast media; Cortical bone; Gadolinium; Magnetic resonance imaging
Substance Nomenclature:: 0 (Contrast Media)
0 (Organometallic Compounds)
AU0V1LM3JT (Gadolinium)
K2I13DR72L (Gadolinium DTPA)
Entry Date(s):: Date Created: 20200915 Date Completed: 20210414 Latest Revision: 20210414
Update Code:: 20240104
DOI:: 10.1007/s00330-020-07258-x
PMID:: 32929642
: Czasopismo naukowe

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Objectives: To investigate the capacity of ultrashort echo time (UTE) T 1 mapping to non-invasively assess gadolinium deposition in cortical bone after gadolinium-based contrast agent (GBCA) administration.
Methods: Twenty-eight New Zealand rabbits (male, 3.0-3.5 kg) were randomly allocated into control, macrocyclic, high-dose macrocyclic, and linear GBCA groups (n = 7 for each group), and respectively given daily doses of 0.9 ml/kg bodyweight saline, 0.3 mmol/kg bodyweight gadobutrol, 0.9 mmol/kg bodyweight gadobutrol, and 0.3 mmol/kg bodyweight gadopentetate dimeglumine for five consecutive days per week over a period of 4 weeks. After a subsequent 4 weeks of recovery, the rabbits were sacrificed and their tibiae harvested. T 1 value of cortical bone was measured using a combination of UTE actual flip angle imaging and variable repetition time on a 7T animal scanner. Gadolinium concentration in cortical bone was measured using inductively coupled plasma mass spectrometry (ICP-MS). Pearson's correlation between R 1 value (R 1 = 1/T 1 ) and gadolinium concentration in cortical bone was assessed.
Results: Bone T 1 values were significantly lower in the lower-dose macrocyclic (329.2 ± 21.0 ms, p < 0.05), higher-dose macrocyclic (316.8 ± 21.7 ms, p < 0.01), and linear (296.8 ± 24.1 ms, p < 0.001) GBCA groups compared with the control group (356.3 ± 19.4 ms). Gadolinium concentrations measured by ICP-MS in the control, lower-dose macrocyclic, higher-dose macrocyclic, and linear GBCA groups were 0.04 ± 0.02 μg/g, 2.60 ± 0.48 μg/g, 4.95 ± 1.17 μg/g, and 13.62 ± 1.55 μg/g, respectively. There was a strong positive correlation between R 1 values and gadolinium concentrations in cortical bone (r = 0.73, p < 0.001).
Conclusions: These results suggest that UTE T 1 mapping has the potential to provide a non-invasive assessment of gadolinium deposition in cortical bone following GBCA administration.
Key Points: • Changes in T 1 value related to gadolinium deposition were found in bone after both linear and macrocyclic GBCA administrations. • R 1 relaxometry correlates strongly with gadolinium concentration in cortical bone. • UTE T 1 mapping provides a potential tool for non-invasively monitoring gadolinium deposition in cortical bone.

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Detection of gadolinium deposition in cortical bone with ultrashort echo time T 1 mapping: an ex vivo study in a rabbit model.