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Tytuł pozycji:

Toxoplasma gondii infection damages the perineuronal nets in a murine model.

Tytuł :
Toxoplasma gondii infection damages the perineuronal nets in a murine model.
Autorzy :
Meurer YDSR; Universidade Federal da Paraíba, Programa de Pós-Graduação em Neurociência Cognitiva e Comportamento, João Pessoa, PB, Brasil.; Universidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Psicobiologia, Natal, RN, Brasil.
Brito RMM; Universidade Federal do Rio Grande do Norte, Departamento de Microbiologia e Parasitologia, Laboratório de Biologia da Málaria e Toxoplasmose - LABMAT, Natal, RN, Brasil.
da Silva VP; Universidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Psicobiologia, Natal, RN, Brasil.
Andade JMA; Universidade Federal do Rio Grande do Norte, Departamento de Microbiologia e Parasitologia, Laboratório de Biologia da Málaria e Toxoplasmose - LABMAT, Natal, RN, Brasil.
Linhares SSG; Universidade Federal do Rio Grande do Norte, Programa de Pós-Graduação em Psicobiologia, Natal, RN, Brasil.
Pereira Junior A; Universidade Federal do Pará, Instituto de Ciências da Sáude, Laboratório de Neuroplasticidade, Belém, PA, Brasil.
de Andrade-Neto VF; Universidade Federal do Rio Grande do Norte, Departamento de Microbiologia e Parasitologia, Laboratório de Biologia da Málaria e Toxoplasmose - LABMAT, Natal, RN, Brasil.
de Sá AL; Universidade Federal do Rio Grande do Norte, Departamento de Microbiologia e Parasitologia, Laboratório de Biologia da Málaria e Toxoplasmose - LABMAT, Natal, RN, Brasil.
Oliveira CBS; Universidade Federal do Rio Grande do Norte, Departamento de Microbiologia e Parasitologia, Laboratório de Biologia da Málaria e Toxoplasmose - LABMAT, Natal, RN, Brasil.
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Źródło :
Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2020 Sep 11; Vol. 115, pp. e200007. Date of Electronic Publication: 2020 Sep 11 (Print Publication: 2020).
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Rio de Janeiro : Instituto Oswaldo Cruz
MeSH Terms :
Toxoplasmosis, Animal*
Cerebellum/*metabolism
Extracellular Matrix/*metabolism
Motor Neurons/*cytology
Neurons/*pathology
Toxoplasmosis/*pathology
Animals ; Cerebellum/cytology ; Disease Models, Animal ; Mice ; Motor Neurons/metabolism ; Neurons/metabolism ; Toxoplasma ; Toxoplasmosis/metabolism
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Entry Date(s) :
Date Created: 20200916 Date Completed: 20200917 Latest Revision: 20201001
Update Code :
20201023
PubMed Central ID :
PMC7491278
DOI :
10.1590/0074-02760200007
PMID :
32935749
Czasopismo naukowe
Background: Behavioral and neurochemical alterations associated with toxoplasmosis may be influenced by the persistence of tissue cysts and activation of an immune response in the brain of Toxoplasma gondii-infected hosts. The cerebral extracellular matrix is organised as perineuronal nets (PNNs) that are both released and ensheath by some neurons and glial cells. There is evidences to suggest that PNNs impairment is a pathophysiological mechanism associated with neuropsychiatric conditions. However, there is a lack of information regarding the impact of parasitic infections on the PNNs integrity and how this could affect the host's behavior.
Objectives: In this context, we aimed to analyse the impact of T. gondii infection on cyst burden, PNNs integrity, and possible effects in the locomotor activity of chronically infected mice.
Methods: We infected mice with T. gondii ME-49 strain. After thirty days, we assessed locomotor performance of animals using the open field test, followed by evaluation of cysts burden and PNNs integrity in four brain regions (primary and secondary motor cortices, prefrontal and somesthetic cortex) to assess the PNNs integrity using Wisteria floribunda agglutinin (WFA) labeling by immunohistochemical analyses.
Findings and Main Conclusions: Our findings revealed a random distribution of cysts in the brain, the disruption of PNNs surrounding neurons in four areas of the cerebral cortex and hyperlocomotor behavior in T. gondii-infected mice. These results can contribute to elucidate the link toxoplasmosis with the establishment of neuroinflammatory response in neuropsychiatric disorders and to raise a discussion about the mechanisms related to changes in brain connectivity, with possible behavioral repercussions during chronic T. gondii infection.

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