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Tytuł:
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Trends in the Incidence and Antibiotic Resistance of Enterococcal Bloodstream Isolates: A 7-Year Retrospective Multicenter Epidemiological Study in Italy.
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Autorzy:
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Monticelli J; Infectious Diseases Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Di Bella S; Infectious Diseases Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Giacobbe DR; Clinica Malattie Infettive, Ospedale Policlinico San Martino-IRCCS, Genoa, Italy.; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Amato G; Azienda Ospedaliera 'A. Cardarelli,' Naples, Italy.
Antonello RM; Infectious Diseases Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Barone E; Azienda Ospedaliera di Valtellina e Valchiavenna, Ospedale di Sondrio, Sondrio, Italy.
Brachelente G; Azienda Ospedaliera di Perugia 'Santa Maria della Misericordia,' Perugia, Italy.
Busetti M; Infectious Diseases Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Carcione D; IRCCS Centro Cardiologico Monzino, Milan, Italy.
Carretto E; Azienda Ospedaliera di Reggio Emilia-'Arcispedale Santa Maria Nuova,' Reggio Emilia, Italy.
Conaldi PG; IRCCS Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), Palermo, Italy.
Degl'Innocenti L; Azienda Ospedaliera 'A. Cardarelli,' Naples, Italy.
Del Puente F; Clinica Malattie Infettive, Ospedale Policlinico San Martino-IRCCS, Genoa, Italy.; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Knezevich A; Infectious Diseases Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Luzzaro F; ASST Lecco-Ospedale 'A. Manzoni,' Lecco, Italy.
Mainelli MT; ASL Roma 1-Presidio Ospedaliero San Filippo Neri, Rome, Italy.
Marchese A; Unità di Microbiologia, Ospedale Policlinico San Martino-IRCCS, Genoa, Italy.; Department of Surgical and Integrated Diagnostic Sciences (DISC), University of Genoa, Genoa, Italy.
Meledandri M; ASL Roma 1-Presidio Ospedaliero San Filippo Neri, Rome, Italy.
Mencacci A; Azienda Ospedaliera di Perugia 'Santa Maria della Misericordia,' Perugia, Italy.; Department of Medicine, University of Perugia, Perugia, Italy.
Miragliotta G; AOU Policlinico di Bari, Bari, Italy.
Monaco F; IRCCS Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT), Palermo, Italy.
Morabito F; Azienda Ospedaliera di Valtellina e Valchiavenna, Ospedale di Sondrio, Sondrio, Italy.
Mosca A; AOU Policlinico di Bari, Bari, Italy.
Nardini P; Azienda Ospedaliera di Reggio Emilia-'Arcispedale Santa Maria Nuova,' Reggio Emilia, Italy.
Principe L; ASST Lecco-Ospedale 'A. Manzoni,' Lecco, Italy.
Riggio D; IRCCS Centro Cardiologico Monzino, Milan, Italy.
Viaggi V; ASST Lecco-Ospedale 'A. Manzoni,' Lecco, Italy.
Viscoli C; Clinica Malattie Infettive, Ospedale Policlinico San Martino-IRCCS, Genoa, Italy.; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Luzzati R; Infectious Diseases Unit, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
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Źródło:
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Microbial drug resistance (Larchmont, N.Y.) [Microb Drug Resist] 2021 Apr; Vol. 27 (4), pp. 529-535. Date of Electronic Publication: 2020 Sep 18.
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Typ publikacji:
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Journal Article; Multicenter Study
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Język:
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English
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Imprint Name(s):
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Original Publication: Larchmont, N.Y. : Mary Ann Liebert, c1995-
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MeSH Terms:
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Drug Resistance, Multiple, Bacterial*
Anti-Bacterial Agents/*pharmacology
Bacteremia/*microbiology
Enterococcus/*drug effects
Aged ; Aged, 80 and over ; Female ; Humans ; Italy/epidemiology ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Retrospective Studies ; Vancomycin Resistance
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Contributed Indexing:
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Keywords: Italy; VRE; antibiotic resistance; enterococcus; incidence
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Substance Nomenclature:
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0 (Anti-Bacterial Agents)
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Entry Date(s):
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Date Created: 20200918 Date Completed: 20211104 Latest Revision: 20211104
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Update Code:
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20240104
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DOI:
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10.1089/mdr.2020.0147
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PMID:
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32945719
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The spread of resistance to vancomycin and other last-resort drugs in Enterococcus spp. remains of concern. In Italy, surveillance data for enterococcal bloodstream isolates in humans are scant. The aim of our study was to assess the incidence trends of bacteremias due to Enterococcus species and their prevalence trends of antimicrobial resistance. We retrospectively included all consecutive not-duplicate Enterococcus species isolated from blood cultures, in patients from 11 Italian hospitals (2011-2017). Incidence was defined as the number of isolates per 10,000 patient-days, while resistance prevalence was defined as the number of resistant strains divided by the number of tested strains. We included 4,858 isolates (59%, 36%, and 5% due to Enterococcus faecalis , E. faecium , and other Enterococcus spp., respectively). Over the study period, the incidence of bacteremias due to E. faecalis (incidence rate ratio [IRR]: 1.02, 95% confidence interval [CI]: 1.00-1.04, p = 0.008) and E. faecium increased (IRR: 1.03, 95% CI: 1.01-1.05, p < 0.001) alongside with the whole enterococcal bacteremias trend (IRR: 1.02, 95% CIs: 1.01-1.04, p = 0.002). A progressive increase in vancomycin-resistant E. faecium (VREfm) bacteremias was observed. Resistance to tigecycline and linezolid was rarely reported. The incidence of enterococcal bloodstream isolates is increasing in Italy, together with the prevalence of VREfm. Resistance to linezolid, a cornerstone drug used in the treatment of VRE bloodstream infection, remains negligible.
