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Tytuł pozycji:

The pediatric solid organ transplant experience with COVID-19: An initial multi-center, multi-organ case series.

Tytuł :
The pediatric solid organ transplant experience with COVID-19: An initial multi-center, multi-organ case series.
Autorzy :
Goss MB; McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Galván NTN; Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
Ruan W; Department of Pediatrics, Gastroenterology, Hepatology, and Nutrition Section, Baylor College of Medicine, Houston, TX, USA.
Munoz FM; Department of Pediatrics, Infectious Diseases Section, Baylor College of Medicine, Houston, TX, USA.
Brewer ED; Renal Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
O'Mahony CA; Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
Melicoff-Portillo E; Pulmonary Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Dreyer WJ; Cardiology Section, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Miloh TA; Division of Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.
Cigarroa FG; Division of Abdominal Transplantation, University Transplant Center, UT Health San Antonio, San Antonio, TX, USA.
Ranch D; Division of Nephrology, Department of Pediatrics, UT Health San Antonio, San Antonio, TX, USA.
Yoeli D; Division of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO, USA.
Adams MA; Division of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO, USA.
Koohmaraie S; Liver Transplantation Service, Texas Children's Hospital, Houston, TX, USA.
Harter DM; Transplant Services, Texas Children's Hospital, Houston, TX, USA.
Rana A; Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
Cotton RT; Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
Carter B; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Keck School of Medicine of USC, Los Angeles, CA, USA.
Patel S; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Keck School of Medicine of USC, Los Angeles, CA, USA.
Moreno NF; McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Leung DH; Department of Pediatrics, Gastroenterology, Hepatology, and Nutrition Section, Baylor College of Medicine, Houston, TX, USA.
Goss JA; Division of Abdominal Transplantation, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
Pokaż więcej
Źródło :
Pediatric transplantation [Pediatr Transplant] 2021 May; Vol. 25 (3), pp. e13868. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji :
Journal Article; Multicenter Study
Język :
English
Imprint Name(s) :
Original Publication: Copenhagen ; Malden, MA : Munksgaard, c1997-
MeSH Terms :
Immunocompromised Host*
Organ Transplantation*
COVID-19/*complications
COVID-19/*immunology
Graft Rejection/*prevention & control
Immunosuppressive Agents/*therapeutic use
Perioperative Care/*methods
Adolescent ; COVID-19/diagnosis ; COVID-19/therapy ; Child ; Child, Preschool ; Female ; Graft Rejection/immunology ; Hospitalization/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Male ; Perioperative Care/statistics & numerical data ; Severity of Illness Index ; Treatment Outcome
References :
Khanna R, Smith C. Cellular immune therapy for viral infections in transplant patients. Indian J Med Res. 2013;138(5):796-807.
Alberici F, Delbarba E, Manenti C, et al. A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV-2 pneumonia. Kidney Int. 2020;97(6):1083-1088.
Fernández-Ruiz M, Andrés A, Loinaz C, et al. COVID-19 in solid organ transplant recipients: a single-center case series from Spain. Am J Transplant. 2020;20(7):1849-1858.
Huang J, Zheng KI, George J, et al. Fatal outcome in a liver transplant recipient with COVID-19. Am J Transplant. 2020;20(7):1907-1910.
Bhoori S, Rossi RE, Citterio D, et al. COVID-19 in long-term liver transplant patients: preliminary experiences from an Italian transplant centre in Lombardy. Lancet Gastroenterol Hepatol. 2020;5(6):532-533.
Travi G, Rossotti R, Merli M, et al. Clinical outcome in solid organ transplant recipients with COVID-19: a single-center experience. Am J Transplant. 2020;20(9):2628-2629.
Tschopp J, L’Huillier AG, Mombelli M, et al. First experience of SARS-CoV-2 infections in solid organ transplant recipients in the Swiss Transplant Cohort Study. Am J Transplant. [2020;20(10):2876-2882.
Zhong J, Tang J, Ye C, et al. The immunology of COVID-19: is immune modulation and option for treatment? Lancet Rheumatol. 2020;2(7):E428-E436.
Russell MR, Halnon NJ, Alejos JC, et al. COVID-19 in a pediatric heart transplant recipient: emergence of donor-specific antibodies. J Heart Lung Transplant. 2020;39(9):732-733.
Heinz N, Griesemar A, Kinney J, et al. A case of an infant with SARS-CoV-2 hepatitis early after liver transplantation. Pediatr Transplant. 2020;24(8):e13778.
Ruan Q, Yang K, Wang W, et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med. 2020;46(5):846-848.
Snyder JJ, Israni AK, Peng Y, et al. Rates of first infection following kidney transplant in the United States. Kidney Int. 2009;75(3):317-326.
Nair V, Jandovitz N, Hirsch JS, et al. COVID-19 in kidney transplant recipients. Am J Transplant. 2020;20(7):1919-1925.
Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. 2020;323(20):2052-2059.
Tagarro A, Epalza C, Santos M, et al. Screening and severity of Coronavirus Disease 2019 (COVID-19) in children in Madrid, Spain. JAMA Pediatr. 2021;175(3):316-317.
Petrilli CM, Jones SA, Yang J, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020;369:m1966.
Riollano-Cruz M, Akkoyun E, Briceno-Brito E, et al. Multisystem inflammatory syndrome in children (MIS-C) related to COVID-19: a New York City experience. J Med Virol. 2021;93(1):424-433.
Zaim S, Chong J, Sankaranarayanan V, et al. COVID-19 and multiorgan response. Curr Probl Cardiol. 2020;45(8):100618.
Ellinghaus D, Degenhardt F, Bujanda L, et al. Genomewide association study of severe COVID-19 with respiratory failure. N Engl J Med. 2020;383(16):1522-1534.
Contributed Indexing :
Keywords: pediatric transplantation*; viral infection*
Substance Nomenclature :
0 (Immunosuppressive Agents)
Entry Date(s) :
Date Created: 20200919 Date Completed: 20210503 Latest Revision: 20210503
Update Code :
20210506
PubMed Central ID :
PMC7537006
DOI :
10.1111/petr.13868
PMID :
32949098
Czasopismo naukowe
The clinical course of COVID-19 in pediatric solid organ transplant recipients remains ambiguous. Though preliminary experiences with adult transplant recipients have been published, literature centered on the pediatric population is limited. We herein report a multi-center, multi-organ cohort analysis of COVID-19-positive transplant recipients ≤ 18 years at time of transplant. Data were collected via institutions' respective electronic medical record systems. Local review boards approved this cross-institutional study. Among 5 transplant centers, 26 patients (62% male) were reviewed with a median age of 8 years. Six were heart recipients, 8 kidney, 10 liver, and 2 lung. Presenting symptoms included cough (n = 12 (46%)), fever (n = 9 (35%)), dry/sore throat (n = 3 (12%)), rhinorrhea (n = 3 (12%)), anosmia (n = 2 (8%)), chest pain (n = 2 (8%)), diarrhea (n = 2 (8%)), dyspnea (n = 1 (4%)), and headache (n = 1 (4%)). Six patients (23%) were asymptomatic. No patient required supplemental oxygen, intubation, or ECMO. Eight patients (31%) were hospitalized at time of diagnosis, 3 of whom were already admitted for unrelated problems. Post-transplant immunosuppression was reduced for only 2 patients (8%). All symptomatic patients recovered within 7 days. Our multi-institutional experience suggests the prognoses of pediatric transplant recipients infected with COVID-19 may mirror those of immunocompetent children, with infrequent hospitalization and minimal treatment, if any, required.
(© 2020 Wiley Periodicals LLC.)

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