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Tytuł:
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Cyclodextrin-Based Synthesis and Host-Guest Chemistry of Plasmonic Nanogap Particles with Strong, Quantitative, and Highly Multiplexable Surface-Enhanced Raman Scattering Signals.
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Autorzy:
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Kim JM; Department of Chemistry, Seoul National University, Seoul 08826, South Korea.
Kim J; Department of Chemistry, Seoul National University, Seoul 08826, South Korea.
Ha M; Department of Chemistry, Seoul National University, Seoul 08826, South Korea.
Nam JM; Department of Chemistry, Seoul National University, Seoul 08826, South Korea.
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Źródło:
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The journal of physical chemistry letters [J Phys Chem Lett] 2020 Oct 01; Vol. 11 (19), pp. 8358-8364. Date of Electronic Publication: 2020 Sep 21.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Washington, D.C. : American Chemical Society
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Entry Date(s):
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Date Created: 20200921 Date Completed: 20201005 Latest Revision: 20201005
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Update Code:
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20240105
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DOI:
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10.1021/acs.jpclett.0c02624
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PMID:
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32956585
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We developed a synthetic strategy to form cyclodextrin-based intrananogap particles (CIPs) with a well-defined ∼1 nm interior gap in a high yield (∼97%), and were able to incorporate 10 different Raman dyes inside the gap using the cyclodextrin-based host-guest chemistry, leading to strong, reproducible, and highly multiplexable surface-enhanced Raman scattering (SERS) signals. The average SERS enhancement factor (EF) for CIPs was 3.0 × 10 9 with a very narrow distribution of the EFs that range from 9.5 × 10 8 to 9.5 × 10 9 for ∼95% of the measured particles. Remarkably, 10 different Raman dyes can be loaded within the nanogap of CIPs, and 6 different Raman dye-loaded CIPs with little spectral overlaps were distinctly detected for cancer cell imaging applications with a single excitation source. Our synthetic strategy provides new platforms in precisely forming plasmonic nanogap structures with all key features for widespread use of SERS including strong signal intensity, reliability in quantification of signal and multiplexing capability.