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Tytuł pozycji:

AMPK allostery: A therapeutic target for the management/treatment of diabetic nephropathy.

Tytuł:
AMPK allostery: A therapeutic target for the management/treatment of diabetic nephropathy.
Autorzy:
Ayinde KS; Institute of Biology, State University of Campinas, Campinas, SP, Brazil.
Olaoba OT; Laboratory of Functional and Structural Biochemistry, Federal University of Sao Carlos, Sao Carlos, SP, Brazil.
Ibrahim B; Computational Biology/Drug Discovery Laboratory, Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Lei D; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Lu Q; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Yin X; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Adelusi TI; Computational Biology/Drug Discovery Laboratory, Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China. Electronic address: .
Źródło:
Life sciences [Life Sci] 2020 Nov 15; Vol. 261, pp. 118455. Date of Electronic Publication: 2020 Sep 18.
Typ publikacji:
Journal Article; Review
Język:
English
Imprint Name(s):
Publication: <2008->: Amsterdam : Elsevier
Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press.
MeSH Terms:
Drug Discovery*
AMP-Activated Protein Kinases/*metabolism
Allosteric Regulation/*drug effects
Diabetic Nephropathies/*drug therapy
Signal Transduction/*drug effects
Animals ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Humans ; Molecular Targeted Therapy
Contributed Indexing:
Keywords: AMPK; Allosteric regulation; DN; Hyperglycemia; Oxidative stress
Substance Nomenclature:
EC 2.7.11.31 (AMP-Activated Protein Kinases)
Entry Date(s):
Date Created: 20200921 Date Completed: 20201119 Latest Revision: 20201119
Update Code:
20240105
DOI:
10.1016/j.lfs.2020.118455
PMID:
32956662
Czasopismo naukowe
Diabetic nephropathy (DN) is a chronic complication of diabetes mellitus (DM) with approximately 30-40% of patients with DM developing nephropathy, and it is the leading cause of end-stage renal diseases and diabetic morbidity. The pathogenesis of DN is primarily associated with irregularities in the metabolism of glucose and lipid leading to hyperglycemia-induced oxidative stress, which has been a major target together with blood pressure regulation in the control of DN progression. However, the regulation of 5' adenosine monophosphate-activated protein kinase (AMPK), a highly conserved protein kinase for maintaining energy balance and cellular growth and repair has been implicated in the development of DM and its complications. Therefore, targeting AMPK pathway has been explored as a therapeutic strategy for the treatment of diabetes and its complication, although most of the mechanisms have not been fully elucidated. In this review, we discuss the structure of AMPK relevant to understanding its allosteric regulation and its role in the pathogenesis and progression of DN. We also identify therapeutic agents that modulate AMPK and its downstream targets with their specific mechanisms of action in the treatment of DN.
(Copyright © 2020 Elsevier Inc. All rights reserved.)

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