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Tytuł:
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Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice.
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Autorzy:
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Moschovaki-Filippidou F; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Steiger S; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Lorenz G; Klinikum rechts der Isar, Department of Nephrology, Technical University Munich, 81675 München, Germany.
Schmaderer C; Klinikum rechts der Isar, Department of Nephrology, Technical University Munich, 81675 München, Germany.
Ribeiro A; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
von Rauchhaupt E; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Cohen CD; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Anders HJ; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Lindenmeyer M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Lech M; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
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Źródło:
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International journal of molecular sciences [Int J Mol Sci] 2020 Sep 23; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 23.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Basel, Switzerland : MDPI, [2000-
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MeSH Terms:
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Cell Movement/*immunology
Glomerular Basement Membrane/*immunology
Glomerulonephritis, Membranous/*immunology
Growth Differentiation Factor 15/*immunology
Proteinuria/*immunology
T-Lymphocytes/*immunology
Animals ; Cell Movement/genetics ; Chemokine CXCL10/genetics ; Chemokine CXCL10/immunology ; Glomerular Basement Membrane/pathology ; Glomerulonephritis, Membranous/genetics ; Glomerulonephritis, Membranous/pathology ; Growth Differentiation Factor 15/genetics ; Mice ; Mice, Knockout ; Proteinuria/genetics ; Proteinuria/pathology ; Receptors, CXCR3/genetics ; Receptors, CXCR3/immunology ; T-Lymphocytes/pathology
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References:
-
Clin J Am Soc Nephrol. 2016 Aug 8;11(8):1392-9. (PMID: 27401523)
J Pathol. 1998 Jan;184(1):89-95. (PMID: 9582533)
J Immunol. 2001 Feb 15;166(4):2818-23. (PMID: 11160349)
Nat Med. 2011 May;17(5):581-8. (PMID: 21516086)
J Am Soc Nephrol. 2017 Jul;28(7):2233-2240. (PMID: 28159780)
J Biol Chem. 1998 Oct 23;273(43):27934-8. (PMID: 9774406)
Nat Rev Immunol. 2002 Oct;2(10):735-47. (PMID: 12360212)
Am J Pathol. 2018 Dec;188(12):2763-2773. (PMID: 30273603)
J Clin Invest. 1997 Nov 1;100(9):2263-75. (PMID: 9410904)
Biochim Biophys Acta Mol Basis Dis. 2020 Aug 1;1866(8):165798. (PMID: 32304740)
Kidney Int. 2003 Jul;64(1):92-101. (PMID: 12787399)
Front Physiol. 2018 Nov 27;9:1712. (PMID: 30542297)
Intern Med J. 2017 Dec;47(12):1393-1399. (PMID: 28869715)
J Am Soc Nephrol. 2007 Jun;18(6):1732-9. (PMID: 17460147)
Front Immunol. 2018 Oct 30;9:2407. (PMID: 30425709)
Dis Markers. 2018 Feb 22;2018:1463940. (PMID: 29682097)
Am J Physiol Lung Cell Mol Physiol. 2019 Oct 1;317(4):L510-L521. (PMID: 31432710)
Ups J Med Sci. 2020 Feb;125(1):37-43. (PMID: 31805809)
Cell Metab. 2018 Sep 4;28(3):353-368. (PMID: 30184485)
Am J Pathol. 1998 Jun;152(6):1541-8. (PMID: 9626058)
Clin Chem. 2013 Jul;59(7):1091-8. (PMID: 23529704)
J Immunol. 1997 May 15;158(10):4978-83. (PMID: 9144517)
Circulation. 2010 Oct 5;122(14):1387-95. (PMID: 20855664)
Nephrol Dial Transplant. 2012 Jan;27(1):70-5. (PMID: 21940482)
J Am Soc Nephrol. 2017 Jan;28(1):47-55. (PMID: 27288012)
Oncogene. 2019 Jun;38(23):4540-4559. (PMID: 30755731)
J Exp Clin Cancer Res. 2018 Apr 10;37(1):80. (PMID: 29636108)
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5682-7. (PMID: 16581909)
Science. 1995 Mar 10;267(5203):1449-56. (PMID: 7533326)
Arthritis Rheum. 2012 Jun;64(6):1730-9. (PMID: 22147649)
Kidney Int. 1994 Jul;46(1):69-78. (PMID: 7523756)
Cell. 2019 Aug 22;178(5):1231-1244.e11. (PMID: 31402172)
J Am Soc Nephrol. 2009 Dec;20(12):2518-24. (PMID: 19820122)
Mediators Inflamm. 2016;2016:5393894. (PMID: 27974866)
Clin Exp Immunol. 1997 Jul;109(1):134-42. (PMID: 9218836)
PLoS One. 2017 Nov 21;12(11):e0187349. (PMID: 29161287)
Nat Med. 2017 Oct;23(10):1215-1219. (PMID: 28846098)
PLoS One. 2011;6(10):e26778. (PMID: 22046355)
Diabetes Care. 2010 Jul;33(7):1567-72. (PMID: 20357380)
Pediatr Nephrol. 2017 Jun;32(6):943-947. (PMID: 27169420)
J Am Soc Nephrol. 2009 Jun;20(6):1282-92. (PMID: 19470687)
Sci Rep. 2017 Aug 17;7(1):8576. (PMID: 28819298)
Curr Opin Rheumatol. 2008 Sep;20(5):538-44. (PMID: 18698174)
Nephron Exp Nephrol. 2007;107(1):e12-21. (PMID: 17671396)
Kidney Int. 2012 Jul;82(1):72-83. (PMID: 22495297)
Immunol Cell Biol. 2011 Feb;89(2):207-15. (PMID: 21221121)
Exp Cell Res. 2011 Mar 10;317(5):620-31. (PMID: 21376175)
Kidney Int. 2002 Jan;61(1):133-40. (PMID: 11786093)
Biochem Biophys Res Commun. 2018 Jun 2;500(2):288-295. (PMID: 29653105)
J Am Soc Nephrol. 2015 Oct;26(10):2399-413. (PMID: 25644111)
Cell. 1991 May 3;65(3):443-9. (PMID: 1673361)
Hum Reprod. 2010 Dec;25(12):2962-71. (PMID: 20884666)
Clin Kidney J. 2015 Apr;8(2):143-50. (PMID: 25815169)
PLoS One. 2013 Nov 13;8(11):e78618. (PMID: 24236027)
Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5116-21. (PMID: 11309499)
Pharmacol Ther. 2019 Jun;198:46-58. (PMID: 30790643)
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11514-9. (PMID: 9326641)
J Virol. 2005 Sep;79(17):11457-66. (PMID: 16103196)
Clin J Am Soc Nephrol. 2017 Jul 7;12(7):1162-1172. (PMID: 28515156)
Am J Pathol. 2011 Sep;179(3):1188-98. (PMID: 21741931)
Pol Arch Intern Med. 2019 Sep 30;129(9):592-597. (PMID: 31389404)
Nat Rev Nephrol. 2017 Jun;13(6):329-343. (PMID: 28287110)
Nat Rev Immunol. 2013 Oct;13(10):738-53. (PMID: 24037418)
Kidney Int. 2012 Jul;82(1):60-71. (PMID: 22437418)
Am J Physiol Renal Physiol. 2012 Apr 1;302(7):F820-9. (PMID: 22205226)
Springer Semin Immunopathol. 2003 May;24(4):377-93. (PMID: 12778334)
J Am Soc Nephrol. 2002 Feb;13(2):359-69. (PMID: 11805163)
J Immunol. 2016 Aug 15;197(4):1089-99. (PMID: 27412416)
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Grant Information:
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LE2621/6-1 Deutsche Forschungsgemeinschaft; AN372/24-1 Deutsche Forschungsgemeinschaft
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Contributed Indexing:
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Keywords: T cells; chemokines; glomerulonephritis; inflammation; innate immunity
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Substance Nomenclature:
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0 (Chemokine CXCL10)
0 (Cxcl10 protein, mouse)
0 (Cxcr3 protein, mouse)
0 (Gdf15 protein, mouse)
0 (Growth Differentiation Factor 15)
0 (Receptors, CXCR3)
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Entry Date(s):
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Date Created: 20200926 Date Completed: 20210223 Latest Revision: 20210223
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Update Code:
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20240105
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PubMed Central ID:
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PMC7583818
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DOI:
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10.3390/ijms21196978
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PMID:
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32977372
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Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) cytokine family and an inflammation-associated protein. Here, we investigated the role of GDF15 in murine anti-glomerular basement membrane (GBM) glomerulonephritis. Glomerulonephritis induction in mice induced systemic expression of GDF15. Moreover, we demonstrate the protective effects for GDF15, as GDF15-deficient mice exhibited increased proteinuria with an aggravated crescent formation and mesangial expansion in anti-GBM nephritis. Herein, GDF15 was required for the regulation of T-cell chemotactic chemokines in the kidney. In addition, we found the upregulation of the CXCR3 receptor in activated T-cells in GDF15-deficient mice. These data indicate that CXCL10/CXCR3-dependent-signaling promotes the infiltration of T cells into the organ during acute inflammation controlled by GDF15. Together, these results reveal a novel mechanism limiting the migration of lymphocytes to the site of inflammation during glomerulonephritis.
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