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Tytuł pozycji:

Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice.

Tytuł:
Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice.
Autorzy:
Moschovaki-Filippidou F; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Steiger S; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Lorenz G; Klinikum rechts der Isar, Department of Nephrology, Technical University Munich, 81675 München, Germany.
Schmaderer C; Klinikum rechts der Isar, Department of Nephrology, Technical University Munich, 81675 München, Germany.
Ribeiro A; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
von Rauchhaupt E; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Cohen CD; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Anders HJ; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Lindenmeyer M; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Lech M; LMU Klinikum, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität Munich, 80336 München, Germany.
Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 23; Vol. 21 (19). Date of Electronic Publication: 2020 Sep 23.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Basel, Switzerland : MDPI, [2000-
MeSH Terms:
Cell Movement/*immunology
Glomerular Basement Membrane/*immunology
Glomerulonephritis, Membranous/*immunology
Growth Differentiation Factor 15/*immunology
Proteinuria/*immunology
T-Lymphocytes/*immunology
Animals ; Cell Movement/genetics ; Chemokine CXCL10/genetics ; Chemokine CXCL10/immunology ; Glomerular Basement Membrane/pathology ; Glomerulonephritis, Membranous/genetics ; Glomerulonephritis, Membranous/pathology ; Growth Differentiation Factor 15/genetics ; Mice ; Mice, Knockout ; Proteinuria/genetics ; Proteinuria/pathology ; Receptors, CXCR3/genetics ; Receptors, CXCR3/immunology ; T-Lymphocytes/pathology
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Grant Information:
LE2621/6-1 Deutsche Forschungsgemeinschaft; AN372/24-1 Deutsche Forschungsgemeinschaft
Contributed Indexing:
Keywords: T cells; chemokines; glomerulonephritis; inflammation; innate immunity
Substance Nomenclature:
0 (Chemokine CXCL10)
0 (Cxcl10 protein, mouse)
0 (Cxcr3 protein, mouse)
0 (Gdf15 protein, mouse)
0 (Growth Differentiation Factor 15)
0 (Receptors, CXCR3)
Entry Date(s):
Date Created: 20200926 Date Completed: 20210223 Latest Revision: 20210223
Update Code:
20240105
PubMed Central ID:
PMC7583818
DOI:
10.3390/ijms21196978
PMID:
32977372
Czasopismo naukowe
Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) cytokine family and an inflammation-associated protein. Here, we investigated the role of GDF15 in murine anti-glomerular basement membrane (GBM) glomerulonephritis. Glomerulonephritis induction in mice induced systemic expression of GDF15. Moreover, we demonstrate the protective effects for GDF15, as GDF15-deficient mice exhibited increased proteinuria with an aggravated crescent formation and mesangial expansion in anti-GBM nephritis. Herein, GDF15 was required for the regulation of T-cell chemotactic chemokines in the kidney. In addition, we found the upregulation of the CXCR3 receptor in activated T-cells in GDF15-deficient mice. These data indicate that CXCL10/CXCR3-dependent-signaling promotes the infiltration of T cells into the organ during acute inflammation controlled by GDF15. Together, these results reveal a novel mechanism limiting the migration of lymphocytes to the site of inflammation during glomerulonephritis.
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