Analytical formulas representing track-structure simulations on DNA damage induced by protons and light ions at radiotherapy-relevant energies.

Tytuł:: Analytical formulas representing track-structure simulations on DNA damage induced by protons and light ions at radiotherapy-relevant energies.
Autorzy:: Kundrát P; Institute of Radiation Medicine, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Department of Radiation Dosimetry, Nuclear Physics Institute CAS, Prague, Czech Republic.
Friedland W; Institute of Radiation Medicine, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Becker J; Institute of Radiation Medicine, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Eidemüller M; Institute of Radiation Medicine, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Ottolenghi A; Radiation Biophysics and Radiobiology Group, Physics Department, University of Pavia, Pavia, Italy.
Baiocco G; Radiation Biophysics and Radiobiology Group, Physics Department, University of Pavia, Pavia, Italy. .
Źródło:: Scientific reports [Sci Rep] 2020 Sep 25; Vol. 10 (1), pp. 15775. Date of Electronic Publication: 2020 Sep 25.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: DNA Damage*
Monte Carlo Method*
Protons*
Radiotherapy*
DNA Breaks, Double-Stranded/radiation effects ; Humans ; Linear Energy Transfer
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Substance Nomenclature:: 0 (Protons)
Entry Date(s):: Date Created: 20200926 Date Completed: 20201222 Latest Revision: 20210925
Update Code:: 20240105
PubMed Central ID:: PMC7519066
DOI:: 10.1038/s41598-020-72857-z
PMID:: 32978459
: Czasopismo naukowe

Pełny tekst

Track structure based simulations valuably complement experimental research on biological effects of ionizing radiation. They provide information at the highest level of detail on initial DNA damage induced by diverse types of radiation. Simulations with the biophysical Monte Carlo code PARTRAC have been used for testing working hypotheses on radiation action mechanisms, for benchmarking other damage codes and as input for modelling subsequent biological processes. To facilitate such applications and in particular to enable extending the simulations to mixed radiation field conditions, we present analytical formulas that capture PARTRAC simulation results on DNA single- and double-strand breaks and their clusters induced in cells irradiated by ions ranging from hydrogen to neon at energies from 0.5 GeV/u down to their stopping. These functions offer a means by which radiation transport codes at the macroscopic scale could easily be extended to predict biological effects, exploiting a large database of results from micro-/nanoscale simulations, without having to deal with the coupling of spatial scales and running full track-structure calculations.

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