Association Between Midlife Obesity and Kidney Function Trajectories: The Atherosclerosis Risk in Communities (ARIC) Study.

Szczegóły
Abstrakt

Tytuł:: Association Between Midlife Obesity and Kidney Function Trajectories: The Atherosclerosis Risk in Communities (ARIC) Study.
Autorzy:: Yu Z; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD.
Grams ME; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD.
Ndumele CE; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD.
Wagenknecht L; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
Boerwinkle E; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Rebholz CM; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD.
Giovannucci EL; Department of Epidemiology, Harvard T. H. Chan School of Public Health; Department of Nutrition, Harvard T. H. Chan School of Public Health; Channing Division of Network Medicine, Brigham and Women's Hospital.
Coresh J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD. Electronic address: .
Źródło:: American journal of kidney diseases : the official journal of the National Kidney Foundation [Am J Kidney Dis] 2021 Mar; Vol. 77 (3), pp. 376-385. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji:: Journal Article; Observational Study; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Publication: Philadelphia Pa : W.B. Saunders
Original Publication: New York, N.Y. : Grune & Stratton, c1981-
MeSH Terms:: Glomerular Filtration Rate*
Kidney Failure, Chronic/*epidemiology
Obesity/*epidemiology
Black or African American ; Body Mass Index ; Creatinine/blood ; Female ; Humans ; Kidney Failure, Chronic/therapy ; Longitudinal Studies ; Male ; Middle Aged ; Proportional Hazards Models ; Renal Replacement Therapy ; Sex Factors ; Waist-Hip Ratio ; White People
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Grant Information:: R01 DK089174 United States DK NIDDK NIH HHS; HHSN268201700002C United States HL NHLBI NIH HHS; HHSN268201700001I United States HL NHLBI NIH HHS; HHSN268201700004I United States HL NHLBI NIH HHS; HHSN268201700004C United States HL NHLBI NIH HHS; HHSN268201700003I United States HL NHLBI NIH HHS; HHSN268201700005C United States HL NHLBI NIH HHS; HHSN268201700001C United States HL NHLBI NIH HHS; HHSN268201700003C United States HL NHLBI NIH HHS; HHSN268201700002I United States HL NHLBI NIH HHS; HHSN268201700005I United States HL NHLBI NIH HHS
Contributed Indexing:: Keywords: Obesity; bioelectrical impedance analysis (BIA); body fat; body mass index (BMI); chronic kidney disease (CKD); end-stage renal disease (ESRD); estimated glomerular filtration rate (eGFR); kidney disease progression; kidney failure; kidney function; midlife; modifiable risk factor; racial/ethnic differences; sex differences; trajectory; waist-to-hip ratio
Substance Nomenclature:: AYI8EX34EU (Creatinine)
Entry Date(s):: Date Created: 20200926 Date Completed: 20210322 Latest Revision: 20240418
Update Code:: 20240418
PubMed Central ID:: PMC7904650
DOI:: 10.1053/j.ajkd.2020.07.025
PMID:: 32979415
: Czasopismo naukowe

Rationale & Objective: Obesity has been related to risk for chronic kidney disease. However, the associations of different measures of midlife obesity with long-term kidney function trajectories and whether they differ by sex and race are unknown.
Study Design: Observational study.
Setting & Participants: 13,496 participants from the Atherosclerosis Risk in Communities (ARIC) Study.
Predictors: Midlife obesity status as measured by body mass index (BMI), waist-to-hip ratio, and predicted percent fat at baseline.
Outcomes: Estimated glomerular filtration rate (eGFR) calculated using serum creatinine level measured at 5 study visits, and incident kidney failure with replacement therapy (KFRT).
Analytical Approach: Mixed models with random intercepts and random slopes for eGFR. Cox proportional hazards models for KFRT.
Results: Baseline mean age was 54 years, median eGFR was 103mL/min/1.73m 2 , and median BMI was 27kg/m 2 . Over 30 years of follow-up, midlife obesity measures were associated with eGFR decline in White and Black women but not consistently in men. Adjusted for age, center, smoking, and coronary heart disease, the differences in eGFR slope per 1-SD higher BMI, waist-to-hip ratio, and predicted percent fat were 0.09 (95% CI, -0.18 to 0.36), -0.25 (95% CI, -0.50 to 0.01), and-0.14 (95% CI, -0.41 to 0.13) mL/min/1.73m 2 per decade for White men; -0.91 (95% CI, -1.15 to-0.67), -0.82 (95% CI, -1.06 to-0.58), and-1.02 (95% CI, -1.26 to-0.78) mL/min/1.73m 2 per decade for White women; -0.70 (95% CI, -1.54 to 0.14), -1.60 (95% CI, -2.42 to-0.78), and-1.24 (95% CI, -2.08 to-0.40) mL/min/1.73m 2 per decade for Black men; and-1.24 (95% CI, -2.08 to-0.40), -1.50 (95% CI, -2.05 to-0.95), and-1.43 (95% CI, -2.00 to-0.86) mL/min/1.73m 2 per decade for Black women. Obesity indicators were independently associated with risk for KFRT for all sex-race groups except White men.
Limitations: Loss to follow-up during 3 decades of follow-up with 5 eGFR assessments.
Conclusions: Obesity status is a risk factor for future decline in kidney function and development of KFRT in Black and White women, with less consistent associations among men.
(Copyright © 2020 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.)

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