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Tytuł pozycji:

Short-term heritable variation overwhelms 200 generations of mutational variance for metabolic traits in Caenorhabditis elegans.

Tytuł :
Short-term heritable variation overwhelms 200 generations of mutational variance for metabolic traits in Caenorhabditis elegans.
Autorzy :
Johnson LM; Department of Biology, University of Florida, Gainesville, Florida, 32611.; Ology Bioservices, Inc., Alachua, Florida, 32615.
Smith OJ; Department of Biology, University of Florida, Gainesville, Florida, 32611.
Hahn DA; Department of Entomology and Nematology, University of Florida, Gainesville, Florida, 32611.; University of Florida Genetics Institute, Gainesville, Florida, 32611.
Baer CF; Department of Biology, University of Florida, Gainesville, Florida, 32611.; University of Florida Genetics Institute, Gainesville, Florida, 32611.
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Źródło :
Evolution; international journal of organic evolution [Evolution] 2020 Nov; Vol. 74 (11), pp. 2451-2464. Date of Electronic Publication: 2020 Oct 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Język :
English
Imprint Name(s) :
Publication: Lawrence, KS : Wiley-Blackwell
Original Publication: Lancaster, Pa. : Society for the Study of Evolution
MeSH Terms :
Genetic Variation*
Mutation Accumulation*
Caenorhabditis elegans/*genetics
Adenosine/metabolism ; Animals ; Caenorhabditis elegans/enzymology
References :
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Grant Information :
R01 GM107227 United States GM NIGMS NIH HHS; R25 GM115298 United States GM NIGMS NIH HHS
Contributed Indexing :
Keywords: Epigenetic*; metabolic enzyme*; mutation accumulation*; mutational variance*; transgenerational inheritance*
Molecular Sequence :
Dryad 10.5061/dryad.9cnp5hqgb
Substance Nomenclature :
K72T3FS567 (Adenosine)
Entry Date(s) :
Date Created: 20200929 Date Completed: 20210329 Latest Revision: 20210329
Update Code :
20210330
PubMed Central ID :
PMC7710592
DOI :
10.1111/evo.14104
PMID :
32989734
Czasopismo naukowe
Metabolic disorders have a large heritable component, and have increased markedly in human populations over the past few generations. Genome-wide association studies of metabolic traits typically find a substantial unexplained fraction of total heritability, suggesting an important role of spontaneous mutation. An alternative explanation is that epigenetic effects contribute significantly to the heritable variation. Here, we report a study designed to quantify the cumulative effects of spontaneous mutation on adenosine metabolism in the nematode Caenorhabditis elegans, including both the activity and concentration of two metabolic enzymes and the standing pools of their associated metabolites. The only prior studies on the effects of mutation on metabolic enzyme activity, in Drosophila melanogaster, found that total enzyme activity presents a mutational target similar to that of morphological and life-history traits. However, those studies were not designed to account for short-term heritable effects. We find that the short-term heritable variance for most traits is of similar magnitude as the variance among MA lines. This result suggests that the potential heritable effects of epigenetic variation in metabolic disease warrant additional scrutiny.
(© 2020 The Authors. Evolution © 2020 The Society for the Study of Evolution.)

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