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Tytuł:
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Impact of a low-carbohydrate and high-fiber diet on nonalcoholic fatty liver disease.
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Autorzy:
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Chen J; Department of Gastroenterology, Huadong Hospital affiliated to Fudan University, Shanghai, China.
Huang Y; Department of Gastroenterology, Huadong Hospital affiliated to Fudan University, Shanghai, China.
Xie H; Department of Nutrition, Huadong hospital, Fudan University, Shanghai, China.
Bai H; Department of Nutrition, Huadong hospital, Fudan University, Shanghai, China.
Lin G; Department of Radiology, Huadong hospital, Fudan University, Shanghai, China.
Dong Y; Department of Radiology, Huadong hospital, Fudan University, Shanghai, China.
Shi D; Department of Gastroenterology, Huadong Hospital affiliated to Fudan University, Shanghai, China.
Wang J; Department of Geriatrics, Huadong hospital, Fudan University, Shanghai, China.
Zhang Q; Department of Gastroenterology, Huadong Hospital affiliated to Fudan University, Shanghai, China.
Zhang Y; Department of Gastroenterology, Huadong Hospital affiliated to Fudan University, Shanghai, China.
Sun J; Department of Nutrition, Huadong hospital, Fudan University, Shanghai, China. Email: .
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Źródło:
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Asia Pacific journal of clinical nutrition [Asia Pac J Clin Nutr] 2020; Vol. 29 (3), pp. 483-490.
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Typ publikacji:
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Journal Article; Randomized Controlled Trial
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Język:
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English
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Imprint Name(s):
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Publication: 2023- : Qingdao : Qingdao University
Original Publication: London, UK : Published for the Asia Pacific Clinical Nutrition Society by Smith-Gordon,
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MeSH Terms:
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Diet, Carbohydrate-Restricted*
Dietary Carbohydrates/*administration & dosage
Dietary Fiber/*administration & dosage
Non-alcoholic Fatty Liver Disease/*diet therapy
Adult ; Body Composition ; Cytokines/genetics ; Cytokines/metabolism ; Dose-Response Relationship, Drug ; Female ; Gene Expression Regulation/drug effects ; Humans ; Liver/pathology ; Male ; Middle Aged
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Substance Nomenclature:
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0 (Cytokines)
0 (Dietary Carbohydrates)
0 (Dietary Fiber)
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Entry Date(s):
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Date Created: 20200929 Date Completed: 20210713 Latest Revision: 20210713
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Update Code:
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20240105
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DOI:
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10.6133/apjcn.202009_29(3).0006
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PMID:
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32990607
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Background and Objectives: To study the effects of a low-carbohydrate and high-fiber diet and education on patients with nonalcoholic fatty liver disease.
Methods and Study Design: We randomly divided 44 patients with nonalcoholic fatty liver disease into two groups: low-carbohydrate and high-fiber diet and education (intervention group), and education alone (control group). Liver and kidney function, fasting plasma glucose, insulin resistance index, body composition, and controlled attenuation parameter were detected before and after the intervention.
Results: After 2 months, the body fat, body weight, abdominal circumference, and visceral fat area, fasting plasma glucose, insulin resistance index, and levels of serum alanine aminotransferase, aspartate transaminase, uric acid, and insulin of the intervention group were significantly lower than before (p<0.05). In the female intervention group, the insulin resistance index and levels of serum alanine aminotransferase, uric acid, triglyceride, fasting plasma glucose, and C-peptide were lower and the level of serum high-density lipoprotein cholesterol was higher than in the female control group (p<0.05). In the male intervention group, the levels of serum alanine aminotransferase, triglyceride, and fasting plasma glucose were lower and the level of serum high-density lipoprotein cholesterol was higher compared with the male control group (p<0.05).
Conclusions: A low-carbohydrate and high-fiber diet and education can effectively reduce the body weight and body fat of patients with nonalcoholic fatty liver disease and improve metabolic indicators such as liver enzymes, blood glucose, blood lipid, and uric acid. Our female patients showed significantly better improvement in the indicators than our male patients.
