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Tytuł:
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Additively manufactured biomedical Ti-Nb-Ta-Zr lattices with tunable Young's modulus: Mechanical property, biocompatibility, and proteomics analysis.
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Autorzy:
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Luo JP; Department of Materials Science and Engineering and Shenzhen Key Laboratory for Additive Manufacturing of High-performance Materials, Southern University of Science and Technology, Shenzhen 518055, China; School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.
Huang YJ; School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.
Xu JY; Department of Materials Science and Engineering and Shenzhen Key Laboratory for Additive Manufacturing of High-performance Materials, Southern University of Science and Technology, Shenzhen 518055, China; School of Mechanical and Mining Engineering, The University of Queensland, Brisbane 4072, Australia.
Sun JF; School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China. Electronic address: .
Dargusch MS; School of Mechanical and Mining Engineering, The University of Queensland, Brisbane 4072, Australia.
Hou CH; Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.
Ren L; Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China.
Wang RZ; Department of Materials Engineering, University of British Columbia, Vancouver V6T 1Z4, Canada.
Ebel T; Institute of Materials Research, Helmholtz-Zentrum Geesthacht, 21502 Geesthacht, Germany.
Yan M; Department of Materials Science and Engineering and Shenzhen Key Laboratory for Additive Manufacturing of High-performance Materials, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address: .
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Źródło:
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Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2020 Sep; Vol. 114, pp. 110903. Date of Electronic Publication: 2020 Mar 26.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam : Elsevier
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MeSH Terms:
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Niobium*
Titanium*
Alloys ; Animals ; Biocompatible Materials ; Elastic Modulus ; Materials Testing ; Mice ; Proteomics
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Contributed Indexing:
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Keywords: Biocompatibility; Mechanical properties; Proteomics; Selective laser melting; Ti-Nb-Ta-Zr (TNTZ)
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Substance Nomenclature:
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0 (Alloys)
0 (Biocompatible Materials)
05175J654G (Niobium)
D1JT611TNE (Titanium)
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Entry Date(s):
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Date Created: 20200930 Date Completed: 20210514 Latest Revision: 20210514
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Update Code:
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20240105
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DOI:
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10.1016/j.msec.2020.110903
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PMID:
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32994002
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Some β-Ti alloys, such as Ti-Nb-Ta-Zr (TNTZ) alloys, exhibit a low Young's modulus and excellent biocompatibility. These alloys are promising new generation biomedical implant materials. Selective laser melting (SLM) can further enable customer-specific manufacturing of β-Ti alloys to satisfy the ever-increasing need for enhanced biomedical products. In this study, we quantitatively determined the relationships between porosity, yield strength, and Young's modulus of SLM-prepared TNTZ lattices. The study constitutes a critical step toward understanding the behavior of the lattice and eventually enables tuning the Young's modulus to match that of human bones. Fatigue properties were also investigated on as-printed lattices in terms of the stress limit. The biocompatibility study included a routine evaluation of the relative cell growth rate and a proteomics analysis using a common mouse fibroblast cell line, L929. The results indicated that the as-printed TNTZ samples exhibited evidence of protein proliferation of the L929 cells, particularly P06733, and that those proteins are responsible for biological processes and molecular functions. They in turn may have promoted cell regeneration, cell motility, and protein binding, which at least partially explains the good biocompatibility of the as-printed TNTZ at the protein level. The study highlights the promising applications of additively manufactured TNTZ as a bone-replacing material from mechanical and biocompatibility perspectives.
Competing Interests: Declaration of competing interest The authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers' bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.
(Copyright © 2020. Published by Elsevier B.V.)
