A hypothalamic novelty signal modulates hippocampal memory.

Tytuł:: A hypothalamic novelty signal modulates hippocampal memory.
Autorzy:: Chen S; Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wakoshi, Japan. .
He L; Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wakoshi, Japan.; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
Huang AJY; Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wakoshi, Japan.
Boehringer R; Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wakoshi, Japan.
Robert V; Institute of Psychiatry and Neuroscience of Paris, Université de Paris, INSERM UMRS1266, Paris, France.
Wintzer ME; Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wakoshi, Japan.
Polygalov D; Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wakoshi, Japan.
Weitemier AZ; Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wakoshi, Japan.
Tao Y; Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wakoshi, Japan.
Gu M; Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wakoshi, Japan.
Middleton SJ; Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wakoshi, Japan.
Namiki K; Laboratory for Cell Function and Dynamics, RIKEN Center for Brain Science, Wakoshi, Japan.
Hama H; Laboratory for Cell Function and Dynamics, RIKEN Center for Brain Science, Wakoshi, Japan.
Therreau L; Institute of Psychiatry and Neuroscience of Paris, Université de Paris, INSERM UMRS1266, Paris, France.
Chevaleyre V; Institute of Psychiatry and Neuroscience of Paris, Université de Paris, INSERM UMRS1266, Paris, France.; GHU PARIS Psychiatry and Neuroscience, Paris, France.
Hioki H; Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Miyawaki A; Laboratory for Cell Function and Dynamics, RIKEN Center for Brain Science, Wakoshi, Japan.; Biotechnological Optics Research Team, RIKEN Center for Advanced Photonics, Wakoshi, Japan.
Piskorowski RA; Institute of Psychiatry and Neuroscience of Paris, Université de Paris, INSERM UMRS1266, Paris, France.; GHU PARIS Psychiatry and Neuroscience, Paris, France.
McHugh TJ; Laboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, Wakoshi, Japan. .; Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan. .
Źródło:: Nature [Nature] 2020 Oct; Vol. 586 (7828), pp. 270-274. Date of Electronic Publication: 2020 Sep 30.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: Basingstoke : Nature Publishing Group
Original Publication: London, Macmillan Journals ltd.
MeSH Terms:: Hippocampus/*cytology
Hippocampus/*physiology
Memory/*physiology
Neural Pathways/*physiology
Animals ; CA2 Region, Hippocampal/cytology ; CA2 Region, Hippocampal/physiology ; Cognition ; Dentate Gyrus/cytology ; Dentate Gyrus/physiology ; Female ; Hypothalamus, Posterior/cytology ; Hypothalamus, Posterior/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/metabolism ; Social Interaction
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Entry Date(s):: Date Created: 20201001 Date Completed: 20201214 Latest Revision: 20210226
Update Code:: 20240105
DOI:: 10.1038/s41586-020-2771-1
PMID:: 32999460
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The ability to recognize information that is incongruous with previous experience is critical for survival. Novelty signals have therefore evolved in the mammalian brain to enhance attention, perception and memory 1,2 . Although the importance of regions such as the ventral tegmental area 3,4 and locus coeruleus 5 in broadly signalling novelty is well-established, these diffuse monoaminergic transmitters have yet to be shown to convey specific information on the type of stimuli that drive them. Whether distinct types of novelty, such as contextual and social novelty, are differently processed and routed in the brain is unknown. Here we identify the supramammillary nucleus (SuM) as a novelty hub in the hypothalamus 6 . The SuM region is unique in that it not only responds broadly to novel stimuli, but also segregates and selectively routes different types of information to discrete cortical targets-the dentate gyrus and CA2 fields of the hippocampus-for the modulation of mnemonic processing. Using a new transgenic mouse line, SuM-Cre, we found that SuM neurons that project to the dentate gyrus are activated by contextual novelty, whereas the SuM-CA2 circuit is preferentially activated by novel social encounters. Circuit-based manipulation showed that divergent novelty channelling in these projections modifies hippocampal contextual or social memory. This content-specific routing of novelty signals represents a previously unknown mechanism that enables the hypothalamus to flexibly modulate select components of cognition.

Comment in: Trends Neurosci. 2021 Feb;44(2):79-81. (PMID: 33256999)

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