Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Co-detection of Bordetella pertussis and other respiratory organisms in children hospitalised with lower respiratory tract infection.

Tytuł:
Co-detection of Bordetella pertussis and other respiratory organisms in children hospitalised with lower respiratory tract infection.
Autorzy:
Muloiwa R; Department of Paediatrics and Child Health, Groote Schuur Hospital, University of Cape Town, Anzio Road, Observatory, Cape Town, South Africa. .
Dube FS; Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Cape Town, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Division of Infection and Immunity, School of Biomedical Sciences, University of Western Australia, Crawley, Australia.
Nicol MP; Division of Infection and Immunity, School of Biomedical Sciences, University of Western Australia, Crawley, Australia.; Division of Medical Microbiology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Hussey GD; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Vaccines for Africa Initiative, Division of Medical Microbiology, University of Cape Town, Cape Town, South Africa.
Zar HJ; SA-MRC Unit On Child and Adolescent Lung Health, University of Cape Town, Cape Town, South Africa.; Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Źródło:
Scientific reports [Sci Rep] 2020 Oct 02; Vol. 10 (1), pp. 16412. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:
Bordetella pertussis/*isolation & purification
Respiratory Tract Infections/*microbiology
Respiratory Tract Infections/*virology
Bordetella pertussis/genetics ; Chlamydophila pneumoniae/genetics ; Chlamydophila pneumoniae/isolation & purification ; Female ; Hospitalization ; Humans ; Incidence ; Infant ; Male ; Multiplex Polymerase Chain Reaction/methods ; Mycoplasma pneumoniae/genetics ; Mycoplasma pneumoniae/isolation & purification ; Respirovirus/genetics ; Respirovirus/isolation & purification ; Sputum/microbiology ; Whooping Cough/microbiology
References:
1World Health Organisation. Disease burden and mortality estimates. https://www.who.int/healthinfo/global_burden_disease/estimates/en/(2020 ).
Brealey, J. C., Sly, P. D., Young, P. R. & Chappell, K. J. Viral bacterial co-infection of the respiratory tract during early childhood. FEMS Microbiol. Lett. https://doi.org/10.1093/femsle/fnv062 (2015). (PMID: 10.1093/femsle/fnv06225877546)
Hammitt, L. L. et al. A preliminary study of pneumonia etiology among hospitalized children in Kenya. Clin. Infect. Diseases 54(Suppl 2), S190-199. https://doi.org/10.1093/cid/cir1071 (2012). (PMID: 10.1093/cid/cir1071)
Zar, H. J. et al. Aetiology of childhood pneumonia in a well vaccinated South African birth cohort: a nested case-control study of the Drakenstein Child Health Study. Lancet Respir. Med. https://doi.org/10.1016/S2213-2600(16)00096-5 (2016). (PMID: 10.1016/S2213-2600(16)00096-5271175474989125)
the PERCH multi-country case-control study. Pneumonia Etiology Research for Child Health Study, G. Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia. Lancet 394, 757–779. https://doi.org/10.1016/S0140-6736(19)30721-4 (2019). (PMID: 10.1016/S0140-6736(19)30721-4)
6World Health Organisation. Immunization, Vaccines and Biologicals. https://www.who.int/immunization/monitoring_surveillance/data/en/ (2020).
Wood, N. & McIntyre, P. Pertussis: review of epidemiology, diagnosis, management and prevention. Paediatr. Respir. Rev. 9, 201–211. https://doi.org/10.1016/j.prrv.2008.05.010 (2008). (PMID: 10.1016/j.prrv.2008.05.01018694712)
Crowcroft, N. S., Stein, C., Duclos, P. & Birmingham, M. How best to estimate the global burden of pertussis?. Lancet Infect. Dis. 3, 413–418 (2003). (PMID: 10.1016/S1473-3099(03)00669-8)
Melvin, J. A. & Bomberger, J. M. Compromised defenses: exploitation of epithelial responses during viral-bacterial co-infection of the respiratory tract. PLoS Pathog. 12, e1005797. https://doi.org/10.1371/journal.ppat.1005797 (2016). (PMID: 10.1371/journal.ppat.1005797276317885025022)
Hallander, H. O., Gnarpe, J., Gnarpe, H. & Olin, P. Bordetella pertussis, Bordetella parapertussis, Mycoplasma pneumoniae, Chlamydia pneumoniae and persistent cough in children. Scand. J. Infect. Dis. 31, 281–286 (1999). (PMID: 10.1080/00365549950163581)
Jackson, L. A., Cherry, J. D., Wang, S. P. & Grayston, J. T. Frequency of serological evidence of Bordetella infections and mixed infections with other respiratory pathogens in university students with cough illnesses. Clin. Infect. Diseases 31, 3–6. https://doi.org/10.1086/313911 (2000). (PMID: 10.1086/313911)
Luis, B. A. L., Guerrero Almeida, M. L. & Ruiz-Palacios, G. M. A place for Bordetella pertussis in PCR-based diagnosis of community-acquired pneumonia. Infect. Dis. (Lond.). https://doi.org/10.1080/23744235.2017.1384958 (2017). (PMID: 10.1080/23744235.2017.138495828958186)
Mooi, F. R. Virulence factors of Bordetella pertussis. Antonie Van Leeuwenhoek 54, 465–474 (1988). (PMID: 10.1007/BF00461865)
Melvin, J. A., Scheller, E. V., Miller, J. F. & Cotter, P. A. Bordetella pertussis pathogenesis: current and future challenges. Nat. Rev. Microbiol. 12, 274–288. https://doi.org/10.1038/nrmicro3235 (2014). (PMID: 10.1038/nrmicro3235246083384205565)
Muloiwa, R., Dube, F. S., Nicol, M. P., Zar, H. J. & Hussey, G. D. Incidence and diagnosis of Pertussis in South African children hospitalized with lower respiratory tract infection. Pediatr. Infect. Dis. J. 35, 611–616. https://doi.org/10.1097/INF.0000000000001132 (2016). (PMID: 10.1097/INF.000000000000113226967813)
Balasubramanian, S., Suresh, N., Ravichandran, C. & Dinesh Chand, G. H. Reference values for oxygen saturation by pulse oximetry in healthy children at sea level in Chennai. Ann. Trop. Paediatr. 26, 95–99. https://doi.org/10.1179/146532806X107421 (2006). (PMID: 10.1179/146532806X10742116709326)
Mau, M. K., Yamasato, K. S. & Yamamoto, L. G. Normal oxygen saturation values in pediatric patients. Hawaii Med. J. 64(42), 44–45 (2005).
Langley, R. & Cunningham, S. How should oxygen supplementation be guided by pulse oximetry in children: do we know the level?. Front. Pediatr. 4, 138. https://doi.org/10.3389/fped.2016.00138 (2016). (PMID: 10.3389/fped.2016.0013828191454)
Dlamini, N. R. & Maja, P. The expanded programme on immunisation in South Africa: a story yet to be told. S. Afr. Med. J. 106, 675–677. https://doi.org/10.7196/SAMJ.2016.v106i7.10956 (2016). (PMID: 10.7196/SAMJ.2016.v106i7.1095627384357)
Planting, N. S. et al. Safety and efficacy of induced sputum in young children hospitalised with suspected pulmonary tuberculosis. Int. J. Tuberculosis Lung Dis. 18, 8–12. https://doi.org/10.5588/ijtld.13.0132 (2014). (PMID: 10.5588/ijtld.13.0132)
Farrell, D. J., Daggard, G. & Mukkur, T. K. Nested duplex PCR to detect Bordetella pertussis and Bordetella parapertussis and its application in diagnosis of pertussis in nonmetropolitan Southeast Queensland, Australia. J. Clin. Microbiol. 37, 606–610 (1999). (PMID: 10.1128/JCM.37.3.606-610.1999)
Tatti, K. M., Sparks, K. N., Boney, K. O. & Tondella, M. L. Novel multitarget real-time PCR assay for rapid detection of Bordetella species in clinical specimens. J Clin. Microbiol. 49, 4059–4066. https://doi.org/10.1128/jcm.00601-11 (2011). (PMID: 10.1128/jcm.00601-11219404643232951)
Versteegh, F. G., Mooi-Kokenberg, E. A., Schellekens, J. F. & Roord, J. J. Bordetella pertussis and mixed infections. Minerva Pediatr. 58, 131–137 (2006). (PMID: 16835573)
Spuesens, E. B. et al. Carriage of Mycoplasma pneumoniae in the upper respiratory tract of symptomatic and asymptomatic children: an observational study. PLoS Med. 10, e1001444. https://doi.org/10.1371/journal.pmed.1001444 (2013). (PMID: 10.1371/journal.pmed.1001444236907543653782)
Heininger, U. & Burckhardt, M. A. Bordetella pertussis and concomitant viral respiratory tract infections are rare in children with cough illness. Pediatr. Infect. Dis. J. 30, 640–644. https://doi.org/10.1097/INF.0b013e3182152d28 (2011). (PMID: 10.1097/INF.0b013e3182152d2821407144)
Piedra, P. A. et al. Bordetella pertussis is an uncommon pathogen in children hospitalized with bronchiolitis during the winter season. Pediatr. Infect. Dis. J. 34, 566–570. https://doi.org/10.1097/INF.0000000000000596 (2015). (PMID: 10.1097/INF.0000000000000596259701094435848)
Siberry, G. K., Paquette, N. R., Ross, T. L., Perl, T. M. & Valsamakis, A. Low prevalence of pertussis among children admitted with respiratory symptoms during respiratory syncytial virus season. Infect. Control Hosp. Epidemiol. 27, 95–97. https://doi.org/10.1086/499999 (2006). (PMID: 10.1086/49999916418999)
Armstrong, G. L., Conn, L. A. & Pinner, R. W. Trends in infectious disease mortality in the United States during the 20th century. JAMA 281, 61–66 (1999). (PMID: 10.1001/jama.281.1.61)
Mills, K. H. G. & Gerdts, V. Mouse and pig models for studies of natural and vaccine-induced immunity to Bordetella pertussis. J. Infect. Dis. 209, S16–S19. https://doi.org/10.1093/infdis/jit488 (2014). (PMID: 10.1093/infdis/jit48824626866)
Ross, P. J. et al. Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine. PLoS Pathog. 9, e1003264. https://doi.org/10.1371/journal.ppat.1003264 (2013). (PMID: 10.1371/journal.ppat.1003264235929883617212)
Crowcroft, N. S. & Pebody, R. G. Recent developments in pertussis. Lancet 367, 1926–1936. https://doi.org/10.1016/S0140-6736(06)68848-X (2006). (PMID: 10.1016/S0140-6736(06)68848-X16765762)
Liu, L. et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet 385, 430–440. https://doi.org/10.1016/S0140-6736(14)61698-6 (2015). (PMID: 10.1016/S0140-6736(14)61698-625280870)
Grant Information:
U54 HG009824 United States HG NHGRI NIH HHS
Entry Date(s):
Date Created: 20201003 Date Completed: 20201215 Latest Revision: 20240207
Update Code:
20240207
PubMed Central ID:
PMC7532201
DOI:
10.1038/s41598-020-73462-w
PMID:
33009451
Czasopismo naukowe
Multiple potential pathogens are frequently co-detected among children with lower respiratory tract infection (LRTI). Evidence indicates that Bordetella pertussis has an important role in the aetiology of LRTI. We aimed to study the association between B. pertussis and other respiratory pathogens in children hospitalised with severe LRTI, and to assess clinical relevance of co-detection. Nasopharyngeal (NP) swabs and induced sputa (IS) were tested with a B. pertussis specific PCR; additionally, IS was tested for other pathogens using a multiplex PCR. We included 454 children, median age 8 months (IQR 4-18), 31 (7%) of whom tested positive for B. pertussis. Children with B. pertussis had more bacterial pathogens detected (3 versus 2; P < 0.001). While B. pertussis showed no association with most pathogens, it was independently associated with Chlamydia pneumoniae, Mycoplasma pneumoniae and parainfluenza viruses with adjusted risk ratios of 4.01 (1.03-15.64), 4.17 (1.42-12.27) and 2.13 (1.03-4.55), respectively. There was a consistent increased risk of severe disease with B. pertussis. Patterns indicated even higher risks when B. pertussis was co-detected with any of the three organisms although not statistically significant. Improving vaccine coverage against B. pertussis would impact not only the incidence of pertussis but also that of severe LRTI generally.
Zaloguj się, aby uzyskać dostęp do pełnego tekstu.

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies