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Tytuł pozycji:

Nicotine, Cotinine, and Tobacco-Specific Nitrosamines Measured in Children's Silicone Wristbands in Relation to Secondhand Smoke and E-cigarette Vapor Exposure.

Tytuł :
Nicotine, Cotinine, and Tobacco-Specific Nitrosamines Measured in Children's Silicone Wristbands in Relation to Secondhand Smoke and E-cigarette Vapor Exposure.
Autorzy :
Quintana PJE; School of Public Health, San Diego State University, San Diego, CA.
Lopez-Galvez N; San Diego State University Research Foundation, San Diego State University, San Diego, CA.
Dodder NG; San Diego State University Research Foundation, San Diego State University, San Diego, CA.
Hoh E; School of Public Health, San Diego State University, San Diego, CA.
Matt GE; Department of Psychology, San Diego State University, San Diego, CA.
Zakarian JM; San Diego State University Research Foundation, San Diego State University, San Diego, CA.
Vyas M; School of Public Health, San Diego State University, San Diego, CA.
Chu L; School of Public Health, San Diego State University, San Diego, CA.
Akins B; School of Public Health, San Diego State University, San Diego, CA.
Padilla S; San Diego State University Research Foundation, San Diego State University, San Diego, CA.
Anderson KA; Environmental and Molecular Toxicology, Oregon State University College of Agricultural Sciences, Corvallis, OR.
Hovell MF; School of Public Health, San Diego State University, San Diego, CA.
Pokaż więcej
Źródło :
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco [Nicotine Tob Res] 2021 Feb 16; Vol. 23 (3), pp. 592-599.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: <2009->: Oxford : Oxford University Press
Original Publication: Abingdon, Oxfordshire, UK : Carfax Pub. and Society for Research on Nicotine and Tobacco, c1999-
MeSH Terms :
Cotinine/*urine
E-Cigarette Vapor/*analysis
Electronic Nicotine Delivery Systems/*statistics & numerical data
Nicotine/*urine
Nitrosamines/*urine
Silicones/*analysis
Tobacco Smoke Pollution/*analysis
Adolescent ; Carcinogens/analysis ; Child ; Child, Preschool ; Female ; Humans ; Male
Grant Information :
R01 ES027815 United States ES NIEHS NIH HHS
Substance Nomenclature :
0 (Carcinogens)
0 (E-Cigarette Vapor)
0 (Nitrosamines)
0 (Silicones)
0 (Tobacco Smoke Pollution)
6M3C89ZY6R (Nicotine)
K5161X06LL (Cotinine)
Entry Date(s) :
Date Created: 20201003 Date Completed: 20210503 Latest Revision: 20210503
Update Code :
20210506
DOI :
10.1093/ntr/ntaa140
PMID :
33009807
Czasopismo naukowe
Introduction: Simple silicone wristbands (WB) hold promise for exposure assessment in children. We previously reported strong correlations between nicotine in WB worn by children and urinary cotinine (UC). Here, we investigated differences in WB chemical concentrations among children exposed to secondhand smoke from conventional cigarettes (CC) or secondhand vapor from electronic cigarettes (EC), and children living with nonusers of either product (NS).
Methods: Children (n = 53) wore three WB and a passive nicotine air sampler for 7 days and one WB for 2 days, and gave a urine sample on day 7. Caregivers reported daily exposures during the 7-day period. We determined nicotine, cotinine, and tobacco-specific nitrosamines (TSNAs) concentrations in WB, nicotine in air samplers, and UC through isotope-dilution liquid chromatography with triple-quadrupole mass spectrometry.
Results: Nicotine and cotinine levels in WB in children differentiated between groups of children recruited into NS, EC exposed, and CC exposed groups in a similar manner to UC. WB levels were significantly higher in the CC group (WB nicotine median 233.8 ng/g silicone, UC median 3.6 ng/mL, n = 15) than the EC group (WB nicotine median: 28.9 ng/g, UC 0.5 ng/mL, n = 19), and both CC and EC group levels were higher than the NS group (WB nicotine median: 3.7 ng/g, UC 0.1 ng/mL, n = 19). TSNAs, including the known carcinogen NNK, were detected in 39% of WB.
Conclusions: Silicone WB show promise for sensitive detection of exposure to tobacco-related contaminants from traditional and electronic cigarettes and have potential for tobacco control efforts.
Implications: Silicone WB worn by children can absorb nicotine, cotinine, and tobacco-specific nitrosamines, and amounts of these compounds are closely related to the child's urinary cotinine. Levels of tobacco-specific compounds in the silicone WB can distinguish patterns of children's exposure to secondhand smoke and e-cigarette vapor. Silicone WB are simple to use and acceptable to children and, therefore, may be useful for tobacco control activities such as parental awareness and behavior change, and effects of smoke-free policy implementation.
(© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

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