Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Tytuł pozycji:

Influence of polysorbates (Tweens) on structural and antimicrobial properties for microemulsions.

Tytuł:
Influence of polysorbates (Tweens) on structural and antimicrobial properties for microemulsions.
Autorzy:
Guo L; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China.
Fang YQ; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China.
Liang XR; College of Pharmacy, Zhejiang University of Technology, Hangzhou 310018, PR China.
Xu YY; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China.
Chen J; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China.
Li YH; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China.
Fang S; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China.
Meng YC; School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China. Electronic address: .
Źródło:
International journal of pharmaceutics [Int J Pharm] 2020 Nov 30; Vol. 590, pp. 119939. Date of Electronic Publication: 2020 Oct 02.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
MeSH Terms:
Anti-Infective Agents*/pharmacology
Polysorbates*
Adolescent ; Child ; Emulsions ; Humans ; Solubility ; Staphylococcus aureus ; Surface-Active Agents ; Water
Contributed Indexing:
Keywords: Antimicrobial efficiency; Dynamic light scattering; Microemulsion; Polysorbate; Small-angle X-ray scattering
Substance Nomenclature:
0 (Anti-Infective Agents)
0 (Emulsions)
0 (Polysorbates)
0 (Surface-Active Agents)
059QF0KO0R (Water)
Entry Date(s):
Date Created: 20201004 Date Completed: 20210617 Latest Revision: 20210617
Update Code:
20240105
DOI:
10.1016/j.ijpharm.2020.119939
PMID:
33011247
Czasopismo naukowe
Polysorbates (Tweens) are one of the most used excipients for essential oils encapsulation. In this work, the polysorbate based microemulsions (PMEs) for R-(+)-limonene (LMN) encapsulation were investigated for the structural and antimicrobial properties. PMEs were constructed using the pseudoternary phase diagrams, and then characterized for electrical conductivity, rheology, size distribution and particle geometry. Conductivity and rheological measurement results showed that Tween 80 and Tween 60 based microemulsions have identical phase transitions. Dynamic light scattering demonstrated that hydrodynamic diameters of oil-in-water microemulsions decreased from 30 nm to 25 nm during the dilution, while small-angle X-ray scattering indicated that their spherical geometries were maintained. PMEs exhibited enhanced antimicrobial efficiencies in vitro against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Interestingly, when Tween 80 was replaced by Tween 60, PME was observed more effective against S. aureus. The two PMEs structural analogues exhibited different antimicrobial efficiencies corresponding to the bioactivity of polysorbates. In conclusion, PMEs can be considered as a desirable system for LMN encapsulation to enhance its solubility and antimicrobial efficiency. Furthermore, the difference in the antimicrobial efficiency suggested that the choice of emulsifiers should be concerned to improve further applications.
(Copyright © 2020 Elsevier B.V. All rights reserved.)

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies