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Tytuł pozycji:

Association of Antibiotics Administration Timing With Mortality in Children With Sepsis in a Tertiary Care Hospital of a Developing Country.

Tytuł :
Association of Antibiotics Administration Timing With Mortality in Children With Sepsis in a Tertiary Care Hospital of a Developing Country.
Autorzy :
Alsadoon A; Department of Pediatrics, Ministry of National Guards-Health Affairs, Riyadh, Saudi Arabia.
Alhamwah M; Department of Pediatrics, Ministry of National Guards-Health Affairs, Riyadh, Saudi Arabia.
Alomar B; Pediatrics Emergency Department, Ministry of National Guards-Health Affairs, Riyadh, Saudi Arabia.
Alsubaiel S; Department of Pediatrics, Ministry of National Guards-Health Affairs, Riyadh, Saudi Arabia.
Almutairi AF; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; Science and Technology Unit, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Vishwakarma RK; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; Department of Biostatistics and Bioinformatics, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Alharthy N; Pediatrics Emergency Department, Ministry of National Guards-Health Affairs, Riyadh, Saudi Arabia.; College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Kazzaz YM; Department of Pediatrics, Ministry of National Guards-Health Affairs, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Pokaż więcej
Źródło :
Frontiers in pediatrics [Front Pediatr] 2020 Sep 09; Vol. 8, pp. 566. Date of Electronic Publication: 2020 Sep 09 (Print Publication: 2020).
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Original Publication: Lausanne : Frontiers Media SA, [2013]-
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Contributed Indexing :
Keywords: Saudi Arabia; children; pediatric intensive care unit; sepsis; sepsis resuscitation bundle; septic shock
Entry Date(s) :
Date Created: 20201005 Latest Revision: 20201006
Update Code :
20201218
PubMed Central ID :
PMC7509148
DOI :
10.3389/fped.2020.00566
PMID :
33014945
Czasopismo naukowe
Objective: To investigate the association between antibiotics administration timing with morbidity and mortality in children with severe sepsis and septic shock, presenting to a tertiary care center in a developing country. Methods: This is a retrospective study of children aged 14 years or younger diagnosed with severe sepsis or septic shock at a free-standing tertiary children's hospital in Saudi Arabia between April 2015 and February 2018. We investigated the association between antibiotic administration timing and pediatric intensive care unit (PICU) mortality, PICU length of stay (LOS), hospital LOS, and ventilation-free days after adjusting for confounders. Results: Among the 189 admissions, 77 patients were admitted with septic shock and 112 with severe sepsis. Overall, the mortality rate was 16.9%. The overall median time from sepsis recognition to antibiotic administration was 105 min (IQR: 65-185.5 min); for septic shock patients, it was 85 min (IQR: 55-148 min), and for severe sepsis, 130 min (IQR: 75.5-199 min). Delayed antibiotic administration (> 3 h) was associated with 3.85 times higher PICU mortality (95% confidence intervals 1.032-14.374) in children with septic shock than in children who receive antibiotics within 3 h, after controlling for severity of illness, age, comorbidities, and volume resuscitation. However, delayed antibiotics administration was not significantly associated with higher PICU mortality in children diagnosed with severe sepsis. Conclusions: Delayed antibiotics administration in children with septic shock admitted to a free-standing children's hospital in a developing country was associated with PICU mortality.
(Copyright © 2020 Alsadoon, Alhamwah, Alomar, Alsubaiel, Almutairi, Vishwakarma, Alharthy and Kazzaz.)

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