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Tytuł:
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Can neuromodulation support the fight against the COVID19 pandemic? Transcutaneous non-invasive vagal nerve stimulation as a potential targeted treatment of fulminant acute respiratory distress syndrome.
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Autorzy:
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Bara GA; Stereotactic and Functional Neurosurgery, Department of Neurosurgery, University Hospital Bonn, Germany.
de Ridder D; Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Maciaczyk J; Stereotactic and Functional Neurosurgery, Department of Neurosurgery, University Hospital Bonn, Germany; Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
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Źródło:
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Medical hypotheses [Med Hypotheses] 2020 Oct; Vol. 143, pp. 110093. Date of Electronic Publication: 2020 Jul 18.
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Typ publikacji:
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Letter
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Język:
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English
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Imprint Name(s):
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Publication: New York : Elsevier, 2002- : Eden Press
Original Publication: Penrith, Eng., Eden Press.
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MeSH Terms:
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Coronavirus Infections/*therapy
Pneumonia, Viral/*therapy
Respiratory Distress Syndrome/*therapy
Vagus Nerve Stimulation/*methods
Autonomic Nervous System ; Betacoronavirus ; COVID-19 ; Critical Illness ; Humans ; Immune System ; Pandemics ; Respiration, Artificial ; SARS-CoV-2 ; Vagus Nerve/physiology
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Entry Date(s):
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Date Created: 20201006 Date Completed: 20201019 Latest Revision: 20210127
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Update Code:
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20240105
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PubMed Central ID:
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PMC7368662
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DOI:
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10.1016/j.mehy.2020.110093
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PMID:
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33017913
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The COVID-19 pandemic has rapidly spread all over the world and caused a major health care crisis. About 20% of patients develop severe disease and require hospitalisation, which is associated with a high mortality rate of up to 97% in those being ventilated and respiratory failure being the leading cause of death. Despite many therapeutic agents being under current investigation there is yet no panacea available. With increasing rates of infection throughout the world, there is an urgent need for new therapeutic approaches to counteract the infection. As the nervous system has shown to be a strong modulator of respiratory function and the immune response, we want to highlight pathways involved in regulation of respiratory function, the neuro-immune axis as well as the rationale for a potential targeted treatment of fulminant acute respiratory distress syndrome via transcutaneous non-invasive vagal nerve stimulation in critically-ill COVID-19 patients.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020. Published by Elsevier Ltd.)
