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Tytuł:
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Recommendations on Acute Kidney Injury Biomarkers From the Acute Disease Quality Initiative Consensus Conference: A Consensus Statement.
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Autorzy:
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Ostermann M; Department of Critical Care and Nephrology, King's College London, Guy's and St Thomas' Hospital, London, United Kingdom.
Zarbock A; Department of Anaesthesiology, Intensive Care Medicine, and Pain Medicine, University Hospital Münster, Münster, Germany.
Goldstein S; Center for Acute Care Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Kashani K; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota.; Division of Nephrology Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Macedo E; Division of Nephrology, Department of Medicine, University of California, San Diego.
Murugan R; Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Bell M; Department of Perioperative Medicine and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden.
Forni L; Intensive Care Unit, Royal Surrey Hospital NHS Foundation Trust, Surrey, United Kingdom.; Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University of Surrey, Surrey, United Kingdom.
Guzzi L; Department of Critical Care Medicine, AdventHealth Waterman, Orlando, Florida.
Joannidis M; Division of Intensive Care and Emergency Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Kane-Gill SL; Department of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania.
Legrand M; Department of Anesthesia and Perioperative Care, University of California, San Francisco.
Mehta R; Department of Medicine, UCSD Medical Center, University of California, San Diego.
Murray PT; School of Medicine, University College Dublin, Dublin, Ireland.
Pickkers P; Department of Intensive Care Medicine, Nijmegen Medical Center, Radboud University, Nijmegen, the Netherlands.
Plebani M; Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy.; Department of Medicine-DIMED, University of Padova, Padova, Italy.
Prowle J; William Harvey Research Institute, Royal London Hospital, Queen Mary University of London, London, United Kingdom.
Ricci Z; Pediatric Cardiac Intensive Care Unit, Bambino Gesu Children's Hospital, Istituto Di Ricovero e Cura a Carattere Scientifico, Rome, Italy.
Rimmelé T; Anesthesiology and Intensive Care Medicine, Edouard Herriot Hospital, Lyon, France.
Rosner M; Division of Nephrology, University of Virginia Health System, Charlottesville.
Shaw AD; Department of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, Alberta, Canada.
Kellum JA; Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Ronco C; Department of Medicine, University of Padova, Padova, Italy.; Department of Nephrology, Dialysis, and Transplantation, International Renal Research Institute, San Bortolo Hospital, Vicenza, Italy.
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Źródło:
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JAMA network open [JAMA Netw Open] 2020 Oct 01; Vol. 3 (10), pp. e2019209. Date of Electronic Publication: 2020 Oct 01.
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Typ publikacji:
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Consensus Development Conference; Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Chicago, IL : American Medical Association, [2018]-
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MeSH Terms:
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Practice Guidelines as Topic*
Quality Indicators, Health Care*
Acute Kidney Injury/*diagnosis
Acute Kidney Injury/*therapy
Critical Care/*standards
Acute Kidney Injury/blood ; Biomarkers ; Female ; Humans ; Male ; Nephrology/standards
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Substance Nomenclature:
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0 (Biomarkers)
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Entry Date(s):
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Date Created: 20201006 Date Completed: 20210104 Latest Revision: 20210106
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Update Code:
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20240105
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DOI:
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10.1001/jamanetworkopen.2020.19209
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PMID:
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33021646
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Importance: In the last decade, new biomarkers for acute kidney injury (AKI) have been identified and studied in clinical trials. Guidance is needed regarding how best to incorporate them into clinical practice.
Objective: To develop recommendations on AKI biomarkers based on existing data and expert consensus for practicing clinicians and researchers.
Evidence Review: At the 23rd Acute Disease Quality Initiative meeting, a meeting of 23 international experts in critical care, nephrology, and related specialties, the panel focused on 4 broad areas, as follows: (1) AKI risk assessment; (2) AKI prediction and prevention; (3) AKI diagnosis, etiology, and management; and (4) AKI progression and kidney recovery. A literature search revealed more than 65 000 articles published between 1965 and May 2019. In a modified Delphi process, recommendations and consensus statements were developed based on existing data, with 90% agreement among panel members required for final adoption. Recommendations were graded using the Grading of Recommendations, Assessment, Development and Evaluations system.
Findings: The panel developed 11 consensus statements for biomarker use and 14 research recommendations. The key suggestions were that a combination of damage and functional biomarkers, along with clinical information, be used to identify high-risk patient groups, improve the diagnostic accuracy of AKI, improve processes of care, and assist the management of AKI.
Conclusions and Relevance: Current evidence from clinical studies supports the use of new biomarkers in prevention and management of AKI. Substantial gaps in knowledge remain, and more research is necessary.
Erratum in: JAMA Netw Open. 2020 Nov 2;3(11):e2029182. (PMID: 33170257)
