Protein Concentrations of Thrombospondin-1, MIP-1β, and S100A8 Suggest the Reflection of a Pregnancy Clock in Mid-Trimester Amniotic Fluid.

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Tytuł:: Protein Concentrations of Thrombospondin-1, MIP-1β, and S100A8 Suggest the Reflection of a Pregnancy Clock in Mid-Trimester Amniotic Fluid.
Autorzy:: Viklund F; Stockholm South General Hospital, Stockholm, Sweden.; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.
Hallingström M; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Kacerovsky M; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.; Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.
Cobo T; BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), Fetal i+D Fetal Medicine Research Center, Institut d'Investigacions Biomèdiques Agustí Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.; Centro de Investigaciones Biomedicas en Enfermedades Raras (CIBER-ER), Barcelona, Spain.
Skogstrand K; Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Hougaard DM; Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Sävman K; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Neonatology, The Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
Carlsson Y; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Tsiartas P; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Juodakis J; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.; School of Maths and Stats, Victoria University of Wellington, Wellington, New Zealand.
Nilsson S; Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden.; Department of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jacobsson B; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden. .; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. .; Department of Genetics and Bioinformatics, Division of Health Data and Digitalisation, Institute of Public Health, Oslo, Norway. .
Źródło:: Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2020 Dec; Vol. 27 (12), pp. 2146-2157. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 2020- : [New York] : Springer
Original Publication: Thousand Oaks, Calif. : Sage
MeSH Terms:: Pregnancy Trimesters*
Amniotic Fluid/*chemistry
Calgranulin A/*analysis
Chemokine CCL4/*analysis
Pregnancy/*metabolism
Thrombospondin 1/*analysis
Adult ; Amniocentesis ; Female ; Gestational Age ; Humans ; Labor Onset ; Pregnancy Outcome ; Prospective Studies
References:: Am J Obstet Gynecol. 2018 Mar;218(3):347.e1-347.e14. (PMID: 29277631)
Obstet Gynecol. 2004 Mar;103(3):551-63. (PMID: 14990421)
Paediatr Perinat Epidemiol. 2007 Sep;21(5):458-64. (PMID: 17697076)
J Reprod Immunol. 2008 Oct;79(1):50-7. (PMID: 18550178)
Am J Reprod Immunol. 2014 Nov;72(5):458-74. (PMID: 25078709)
J Perinatol. 2005 May;25(5):341-8. (PMID: 15861199)
J Matern Fetal Neonatal Med. 2011 Dec;24(12):1444-55. (PMID: 21958433)
BMJ. 2006 May 6;332(7549):1080. (PMID: 16675816)
Front Immunol. 2012 Oct 23;3:321. (PMID: 23109934)
J Matern Fetal Neonatal Med. 2012 Jun;25(6):812-7. (PMID: 21726173)
Am J Obstet Gynecol. 1998 Oct;179(4):1051-5. (PMID: 9790397)
BMC Public Health. 2013;13 Suppl 3:S2. (PMID: 24564800)
Nat Med. 1995 May;1(5):460-3. (PMID: 7585095)
J Immunol Methods. 2009 Jan 1;340(1):55-64. (PMID: 18983846)
Nat Immunol. 2017 Jun;18(6):622-632. (PMID: 28459433)
Cytokine. 2016 May;81:82-7. (PMID: 26954343)
J Matern Fetal Neonatal Med. 2015 Jul;28(11):1343-1359. (PMID: 25123515)
J Obstet Gynaecol Res. 2016 Jul;42(7):776-83. (PMID: 26990253)
BMJ. 2012 Mar 01;344:e896. (PMID: 22381676)
Methods. 2012 Feb;56(2):204-12. (PMID: 22001645)
Methods. 2012 Apr;56(4):508-13. (PMID: 22465283)
Am J Reprod Immunol. 1997 Mar;37(3):227-31. (PMID: 9127643)
PLoS One. 2016 Aug 04;11(8):e0160335. (PMID: 27490719)
J Matern Fetal Neonatal Med. 2019 Aug;32(15):2543-2546. (PMID: 29471751)
BMC Pregnancy Childbirth. 2014 Jul 22;14:241. (PMID: 25048443)
Hum Reprod Update. 2016 Sep;22(5):535-60. (PMID: 27363410)
Immunol Rev. 2017 Nov;280(1):41-56. (PMID: 29027222)
Reproduction. 2016 Dec;152(6):R277-R292. (PMID: 27679863)
Am J Obstet Gynecol. 2002 Feb;186(2):268-73. (PMID: 11854648)
Cold Spring Harb Perspect Med. 2015 Apr 27;5(11):. (PMID: 25918180)
Arch Gynecol Obstet. 2012 Jan;285(1):37-43. (PMID: 21526362)
Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515. (PMID: 30395287)
Cytokine. 2016 Sep;85:67-70. (PMID: 27289215)
JAMA. 2010 Sep 1;304(9):976-82. (PMID: 20810375)
PLoS One. 2016 Sep 13;11(9):e0162506. (PMID: 27622562)
Placenta. 2003 Apr;24 Suppl A:S33-46. (PMID: 12842412)
N Engl J Med. 2017 Sep 21;377(12):1156-1167. (PMID: 28877031)
J Matern Fetal Neonatal Med. 2013 Feb;26(3):285-9. (PMID: 23020666)
G3 (Bethesda). 2017 Apr 3;7(4):1349-1356. (PMID: 28250013)
J Matern Fetal Neonatal Med. 2004 May;15(5):313-7. (PMID: 15280122)
N Engl J Med. 2000 May 18;342(20):1500-7. (PMID: 10816189)
Am J Obstet Gynecol. 1998 Mar;178(3):546-50. (PMID: 9539524)
J Thromb Haemost. 2011 Nov;9(11):2221-8. (PMID: 21883885)
Obstet Gynecol. 2004 Oct;104(4):727-33. (PMID: 15458893)
Placenta. 2019 Apr;79:40-45. (PMID: 30454905)
Am J Obstet Gynecol. 2014 Feb;210(2):125.e1-125.e15. (PMID: 24274987)
Mol Endocrinol. 2012 Aug;26(8):1356-69. (PMID: 22734038)
Sci Immunol. 2017 Sep 1;2(15):. (PMID: 28864494)
Obstet Gynecol. 2009 Aug;114(2 Pt 1):268-77. (PMID: 19622987)
Public Health. 2014 May;128(5):399-403. (PMID: 24794180)
Nat Commun. 2019 Sep 2;10(1):3927. (PMID: 31477735)
PLoS One. 2012;7(2):e30659. (PMID: 22347395)
J Matern Fetal Neonatal Med. 2012 Jun;25(6):558-67. (PMID: 22578261)
J Leukoc Biol. 2007 Jan;81(1):1-5. (PMID: 17032697)
N Engl J Med. 1999 Aug 26;341(9):660-6. (PMID: 10460818)
J Matern Fetal Neonatal Med. 2020 Feb;33(4):583-592. (PMID: 30196733)
PLoS One. 2016 May 23;11(5):e0155164. (PMID: 27214132)
BMC Pregnancy Childbirth. 2014 Sep 30;14:340. (PMID: 25273669)
Front Immunol. 2017 Dec 13;8:1822. (PMID: 29326708)
Semin Fetal Neonatal Med. 2006 Oct;11(5):317-26. (PMID: 16839830)
Mol Hum Reprod. 2004 Feb;10(2):109-13. (PMID: 14742695)
Contributed Indexing:: Keywords: Amniotic fluid; Gestational duration; Inflammation; Mid-trimester; Proteins
Substance Nomenclature:: 0 (Calgranulin A)
0 (Chemokine CCL4)
0 (S100A8 protein, human)
0 (Thrombospondin 1)
Entry Date(s):: Date Created: 20201007 Date Completed: 20201215 Latest Revision: 20201215
Update Code:: 20240105
PubMed Central ID:: PMC7593301
DOI:: 10.1007/s43032-020-00229-z
PMID:: 33026626
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The development of immunoassays enables more sophisticated studies of the associations between protein concentrations and pregnancy outcomes, allowing early biomarker identification that can improve neonatal outcomes. The aim of this study was to explore associations between selected mid-trimester amniotic fluid proteins and (1) overall gestational duration and (2) spontaneous preterm delivery. A prospective cohort study, including women undergoing mid-trimester transabdominal genetic amniocentesis, was performed in Gothenburg, Sweden, 2008-2016 (n = 1072). A panel of 27 proteins related to inflammation was analyzed using Meso-Scale multiplex technology. Concentrations were adjusted for gestational age at sampling, experimental factors, year of sampling, and covariates (maternal age at sampling, parity (nulliparous/multiparous), smoking at first prenatal visit, and in vitro fertilization). Cox regression analysis of the entire cohort was performed to explore possible associations between protein concentrations and gestational duration. This was followed by Cox regression analysis censored at 259 days or longer, to investigate whether associations were detectable in women with spontaneous preterm delivery (n = 47). Finally, linear regression models were performed to analyze associations between protein concentrations and gestational duration in women with spontaneous onset of labor at term (n = 784). HMG-1, IGFBP-1, IL-18, MIP-1α, MIP-1β, S100A8, and thrombospondin-1 were significantly associated with gestational duration at term, but not preterm. Increased concentrations of thrombospondin-1, MIP-1β, and S100A8, respectively, were significantly associated with decreased gestational duration after the Holm-Bonferroni correction in women with spontaneous onset of labor at term. This adds to the concept of a pregnancy clock, where our findings suggest that such a clock is also reflected in the amniotic fluid at early mid-trimester, but further research is needed to confirm this.

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