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Tytuł:
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Predicting Pathological Tumor Size in Prostate Cancer Based on Multiparametric Prostate Magnetic Resonance Imaging and Preoperative Findings.
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Autorzy:
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Pooli A; UCLA Institute of Urologic Oncology, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Johnson DC; UCLA Institute of Urologic Oncology, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Shirk J; UCLA Institute of Urologic Oncology, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Markovic D; Division of General Internal Medicine and Health Services Research, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.
Sadun TY; UCLA Institute of Urologic Oncology, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Sisk AE Jr; Genitourinary Pathology, Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Mohammadian Bajgiran A; Diagnostic and Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Afshari Mirak S; Diagnostic and Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Felker ER; Diagnostic and Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Hughes AK; UCLA Health.
Raman SS; Diagnostic and Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Reiter RE; UCLA Institute of Urologic Oncology, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California.
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Źródło:
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The Journal of urology [J Urol] 2021 Feb; Vol. 205 (2), pp. 444-451. Date of Electronic Publication: 2020 Oct 07.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2019- : [Philadelphia, PA] : Wolters Kluwer
Original Publication: Baltimore : Lippincott Williams & Wilkins
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MeSH Terms:
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Multiparametric Magnetic Resonance Imaging*
Prostatic Neoplasms/*diagnostic imaging
Prostatic Neoplasms/*pathology
Adult ; Aged ; Aged, 80 and over ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Preoperative Period ; Prostatectomy ; Prostatic Neoplasms/surgery ; Retrospective Studies ; Tumor Burden
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Contributed Indexing:
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Keywords: multiparametric magnetic resonance imaging; prostate-specific antigen; prostatic neoplasms; tumor burden
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Entry Date(s):
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Date Created: 20201007 Date Completed: 20210225 Latest Revision: 20210225
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Update Code:
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20240105
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DOI:
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10.1097/JU.0000000000001389
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PMID:
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33026934
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Purpose: Oncologic efficacy of focal therapies in prostate cancer depends heavily on accurate tumor size estimation. We aim to evaluate the agreement between radiologic tumor size and pathological tumor size, and identify predictors of pathological tumor size.
Materials and Methods: This single arm study cohort included all consecutive patients with biopsy proven prostate cancer and a corresponding PI-RADS®v2 3 or greater index tumor on multiparametric magnetic resonance imaging who subsequently underwent radical prostatectomy. Radiologic tumor size was defined as maximum tumor diameter on multiparametric magnetic resonance imaging and compared to whole mount histopathology tumor correlates. The difference between radiologic tumor size and pathological tumor size was assessed, and clinical, pathological and radiographic predictors of pathological tumor size were examined.
Results: A total of 461 consecutive lesions in 441 men were included for statistical analysis. Mean radiologic tumor size and pathological tumor size was 1.57 and 2.37 cm, respectively (p <0.001). Radiologic tumor size consistently underestimated pathological tumor size regardless of the preoperative covariates, and the degree of underestimation increased with smaller radiologic tumor size and lower PI-RADSv2 scores. Pathological tumor size was significantly larger for biopsy Gleason Grade Group (GG) 5 compared to GG1 (mean change 0.37 cm, p=0.014), PI-RADSv2 5 lesions compared to PI-RADSv2 4 (mean change 0.26, p=0.006) and higher prostate specific antigen density. The correlations between radiologic tumor size vs pathological tumor size according to biopsy GG and radiologic covariates were generally low with correlation coefficients ranging between 0.1 and 0.65.
Conclusions: Multiparametric magnetic resonance imaging frequently underestimates pathological tumor size and the degree of underestimation increases with smaller radiologic tumor size and lower PI-RADSv2 scores. Therefore, a larger ablation margin may be required for smaller tumors and lesions with lower PI-RADSv2 scores. These variables must be considered when estimating treatment margins in focal therapy.
Comment in: J Urol. 2021 Feb;205(2):451. (PMID: 33253070)
