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Tytuł:
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Preocular sensor system for concurrent monitoring of glucose levels and dry eye syndrome using tear fluids.
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Autorzy:
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Han JH; Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, Korea.
Cho YC; Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, Korea.
Koh WG; Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, Korea.
Choy YB; Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, Korea.; Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea.; Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea.
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Źródło:
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PloS one [PLoS One] 2020 Oct 07; Vol. 15 (10), pp. e0239317. Date of Electronic Publication: 2020 Oct 07 (Print Publication: 2020).
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: San Francisco, CA : Public Library of Science
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MeSH Terms:
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Biosensing Techniques/*methods
Blood Glucose/*analysis
Dry Eye Syndromes/*diagnosis
Tears/*chemistry
Animals ; Area Under Curve ; Biosensing Techniques/instrumentation ; Electrodes ; Male ; ROC Curve ; Rabbits
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References:
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Substance Nomenclature:
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0 (Blood Glucose)
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Entry Date(s):
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Date Created: 20201007 Date Completed: 20201119 Latest Revision: 20201119
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Update Code:
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20240105
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PubMed Central ID:
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PMC7540859
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DOI:
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10.1371/journal.pone.0239317
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PMID:
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33027299
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The present study demonstrated a noninvasive preocular sensor system for the concurrent monitoring of diabetes and one of its prevalent complications, dry eye syndrome (DES), using tear fluids. Two distinct sensors, i.e., the glucose and DES sensors, were prepared and encased together in a single housing unit to produce the sensor system, and the tip was designed to be in contact with the eye surface noninvasively to collect and deliver tear fluid to the sensors. The glucose sensor was modified from a commercially available electrochemical sensor to allow for the measurement of glucose concentrations, even in a small amount of collected tear fluid. The DES sensor was equipped with a microchannel spaced with two parallel electrodes to determine the amount of collected tear fluid. In vivo experimental results revealed that with the collected tear fluid of about 0.6-1.0 μl, the sensor system estimated the blood glucose concentrations with acceptable accuracy compared with that of the glucometer in clinical use. The DES condition in animals was diagnosed with high sensitivity (91.7%) and specificity (83.3%).
Competing Interests: The authors have declared that no competing interests exist.
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