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Tytuł pozycji:

Toxicological outcome of exposure to psychoactive drugs carbamazepine and diazepam on non-target insect Nauphoeta cinerea.

Tytuł :
Toxicological outcome of exposure to psychoactive drugs carbamazepine and diazepam on non-target insect Nauphoeta cinerea.
Autorzy :
Adedara IA; Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address: .
Ajayi BO; Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Afolabi BA; Departamento de Bioquímica e Biologia Molecular, CCNE, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil.
Awogbindin IO; Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Rocha JBT; Departamento de Bioquímica e Biologia Molecular, CCNE, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil.
Farombi EO; Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Pokaż więcej
Źródło :
Chemosphere [Chemosphere] 2021 Feb; Vol. 264 (Pt 1), pp. 128449. Date of Electronic Publication: 2020 Sep 28.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford, New York, : Pergamon Press.
MeSH Terms :
Diazepam*/toxicity
Water Pollutants, Chemical*/toxicity
Animals ; Carbamazepine/toxicity ; Cockroaches ; Humans ; Lipid Peroxidation ; Psychotropic Drugs
Contributed Indexing :
Keywords: Behavior; Chemical mixtures; Insects; Oxido-inflammatory stress; Psychoactive drugs
Substance Nomenclature :
0 (Psychotropic Drugs)
0 (Water Pollutants, Chemical)
33CM23913M (Carbamazepine)
Q3JTX2Q7TU (Diazepam)
Entry Date(s) :
Date Created: 20201008 Date Completed: 20201222 Latest Revision: 20210712
Update Code :
20210713
DOI :
10.1016/j.chemosphere.2020.128449
PMID :
33032224
Czasopismo naukowe
The continuous detection of human pharmaceuticals during environmental biomonitoring is a global concern because of the menaces they may exert on non-target organisms. Carbamazepine (CBZ) and diazepam (DZP) are commonly prescribed psychotropic drugs which have been reported to coexist in the environment globally. Nauphoeta cinerea is a common insect with high ecological impact. This study elucidated the influence of co-exposure to DZP (0.5 and 1.0 μg kg -1 diet) and CBZ (1.5 and 3.0 μg kg -1 diet) for 42 days on the behavior and biochemical responses in Nauphoeta cinerea. Results showed that DZP alone did not induce adverse effect on the behavior and antioxidant status in the exposed insects. However, exposure to CBZ alone and binary mixtures of DZP and CBZ significantly decreased locomotor and exploratory accomplishments evidenced by decreased mobile episodes, total mobile time, maximum speed, total distance traveled, absolute turn angle, body rotation and path efficiency in comparison with control. The decline observed in the exploratory activities of insects fed with CBZ alone and the mixtures was confirmed by track plots and heat maps. Further, acetylcholinesterase and antioxidant enzyme activities decreased significantly whereas reactive oxygen and nitrogen species, nitric oxide and lipid peroxidation levels increased significantly in the hemolymph, head and midgut of insects exposed to CBZ alone and the mixtures. Collectively, CBZ alone and binary mixtures of CBZ and DZP caused neurotoxicity via induction of inflammatory and oxidative stress in insects. Nauphoeta cinerea may be a potential non-target insect model for monitoring ecotoxicological hazard of pharmaceuticals.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
Comment in: Reg Anesth Pain Med. 2021 Jul;46(7):568-569. (PMID: 34145068)

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