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Tytuł:
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The epidemic of erythromycin-resistant Bordetella pertussis with limited genome variation associated with pertussis resurgence in China.
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Autorzy:
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Yao K; Beijing Pediatric Research Institute of Beijing Children's Hospital Affiliated to Capital Medical University , Beijing, China.
Deng J; Department of Infectious Disease and Department of Pulmonology, Shenzhen Children's Hospital , Shenzhen, China.
Ma X; Pediatric Department, Jinan Children's Hospital , Jinan, China.
Dai W; WeHealthGene Institute , Shenzhen, China.
Chen Q; Department of Pulmonology, Jiangxi Provincial Children's Hospital , Nanchang, China.
Zhou K; Department of Infectious Disease, Nanjing Children's Hospital , Nanjing, China.
Ye J; Clinical Laboratory, Jiaxing University Affiliated Women and Children Hospital , Jiaxing, China.
Shi W; Beijing Pediatric Research Institute of Beijing Children's Hospital Affiliated to Capital Medical University , Beijing, China.
Wang H; Department of Infectious Disease and Department of Pulmonology, Shenzhen Children's Hospital , Shenzhen, China.
Li D; WeHealthGene Institute , Shenzhen, China.
Wang H; Department of Infectious Disease and Department of Pulmonology, Shenzhen Children's Hospital , Shenzhen, China.
Wang J; Beijing Pediatric Research Institute of Beijing Children's Hospital Affiliated to Capital Medical University , Beijing, China.; Pediatric Department, Peking University First Hospital , Beijing, China.
Zhang J; Department of Infectious Disease and Department of Pulmonology, Shenzhen Children's Hospital , Shenzhen, China.
Wu D; Department of Pulmonology, Jiangxi Provincial Children's Hospital , Nanchang, China.
Xie G; Beijing Pediatric Research Institute of Beijing Children's Hospital Affiliated to Capital Medical University , Beijing, China.; Department of Infectious Disease and Department of Pulmonology, Shenzhen Children's Hospital , Shenzhen, China.
Shen K; Beijing Pediatric Research Institute of Beijing Children's Hospital Affiliated to Capital Medical University , Beijing, China.
Zheng Y; Department of Infectious Disease and Department of Pulmonology, Shenzhen Children's Hospital , Shenzhen, China.
Yang Y; Beijing Pediatric Research Institute of Beijing Children's Hospital Affiliated to Capital Medical University , Beijing, China.; Department of Infectious Disease and Department of Pulmonology, Shenzhen Children's Hospital , Shenzhen, China.; WeHealthGene Institute , Shenzhen, China.
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Źródło:
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Expert review of vaccines [Expert Rev Vaccines] 2020 Nov; Vol. 19 (11), pp. 1093-1099. Date of Electronic Publication: 2020 Oct 21.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Publication: 2015- : Abingdon, Oxford : Taylor & Francis
Original Publication: London : Future Drugs Ltd., 2002-
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MeSH Terms:
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Bordetella pertussis/*isolation & purification
Erythromycin/*pharmacology
Pertussis Vaccine/*administration & dosage
Whooping Cough/*epidemiology
Anti-Bacterial Agents/pharmacology ; Bordetella pertussis/drug effects ; Bordetella pertussis/genetics ; China/epidemiology ; Drug Resistance, Bacterial ; Humans ; Immunization Programs ; Vaccines, Acellular/administration & dosage ; Whole Genome Sequencing ; Whooping Cough/microbiology ; Whooping Cough/prevention & control
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Contributed Indexing:
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Keywords: Bordetella pertussis; SNP; erythromycin resistance; vaccine; whole genome analysis
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Substance Nomenclature:
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0 (Anti-Bacterial Agents)
0 (Pertussis Vaccine)
0 (Vaccines, Acellular)
63937KV33D (Erythromycin)
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Entry Date(s):
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Date Created: 20201009 Date Completed: 20210414 Latest Revision: 20210414
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Update Code:
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20240105
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DOI:
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10.1080/14760584.2020.1831916
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PMID:
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33034224
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Background: The resurgence of Bordetella pertussis infections leading to whooping cough is a concern in many parts of the world. The number of pertussis cases in China has increased significantly since 2013.
Research Design and Methods: In this study, whole-genome sequencing analysis was performed for 388 B. pertussis strains isolated in China from the 1970s to 2018, combining 594 published strains from around the world.
Results: This study revealed that lineage V diverged about 50 years ago in China, while lineage IV is dominant in the other countries. It also revealed that the erythromycin-resistant sub-lineages Va, Vb, and Vc with limited genomic variation emerged 11 ~ 12 years ago. These three sub-lineages were identified after the co-purified acellular vaccines (cp-ACVs) completely replaced the previous whole cell vaccines (WCVs) after the national immunization program of 2012. It suggests that the cp-ACVs cannot induce immunity that is potent enough to restrict the spread of the lineage V, antibiotic abuse further favors the spread of this lineage in China.
Conclusions: These findings demand a reassessment of the immunization strategy and development of new vaccines in China to stop the resurgence and drug resistance of B. pertussis .
