Pathophysiology of high fat diet induced obesity: impact of probiotic banana juice on obesity associated complications and hepatosteatosis.

Tytuł:: Pathophysiology of high fat diet induced obesity: impact of probiotic banana juice on obesity associated complications and hepatosteatosis.
Autorzy:: Konda PY; Department of Biochemistry, Krijan Biotech, Malleshwaram, Bangalore, India. .
Poondla V; Department of Chemistry, Indian Institute of Technology Hyderabad, Sangareddy, India.
Jaiswal KK; Department of Chemistry, Uttaranchal University, Dehradun, India.
Dasari S; Department of Biochemistry, Sri Venkateswara University, Tirupati, India.
Uyyala R; Department of Biochemistry, Krijan Biotech, Malleshwaram, Bangalore, India.; Department of Organic Chemistry, Sri Padmavati Mahila Visvavidyalayam, Tirupati, India.
Surtineni VP; Department of Biochemistry, Sri Venkateswara University, Tirupati, India.
Egi JY; Department of Biotechnology, Sri Venkateswara University, Tirupati, India.
Masilamani AJA; Department of Botany, Sri Krishnadevaraya University, Anantapur, India.
Bestha L; Department of Zoology, Sri Krishnadevaraya University, Anantapur, India.
Konanki S; Department of Biotechnology, Sri Krishnadevaraya University, Anantapur, India.
Muthulingam M; Department of Ecology and Environmental Sciences, Pondicherry University, Puducherry, India.
Lingamgunta LK; Department of Biochemistry, Sri Venkateswara University, Tirupati, India.
Aloor BP; Department of Botany, Rayalaseema University, Kurnool, India.
Tirumalaraju S; Mahatma Gandhi National Institute of Research and Social Action, Banjara Hills, Hyderabad, India.
Sade A; Department of Botany, Sri Venkateswara University, Tirupati, India.
Ratnam Kamsala V; Department of Botany, Rayalaseema University, Kurnool, India.
Nagaraja S; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.
Ramakrishnan R; Department of Virology, Sri Venkateswara University, Tirupati, India.
Natesan V; Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Chidambaram, India. .
Źródło:: Scientific reports [Sci Rep] 2020 Oct 09; Vol. 10 (1), pp. 16894. Date of Electronic Publication: 2020 Oct 09.
Typ publikacji:: Journal Article
Język:: English
Imprint Name(s):: Original Publication: London : Nature Publishing Group, copyright 2011-
MeSH Terms:: Diet, High-Fat/*adverse effects
Fatty Liver/*drug therapy
Musa/*metabolism
Obesity/*drug therapy
Probiotics/*pharmacology
Animals ; Antioxidants/metabolism ; Body Weight/drug effects ; Fatty Liver/metabolism ; Fruit and Vegetable Juices ; Insulin Resistance/physiology ; Lipid Metabolism/drug effects ; Lipid Peroxidation/drug effects ; Lipids ; Liver/drug effects ; Liver/metabolism ; Male ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Obesity/metabolism ; Oxidative Stress/drug effects ; Rats ; Rats, Wistar ; Saccharomyces cerevisiae/drug effects ; Triglycerides/metabolism
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Substance Nomenclature:: 0 (Antioxidants)
0 (Lipids)
0 (Triglycerides)
Entry Date(s):: Date Created: 20201010 Date Completed: 20210112 Latest Revision: 20240329
Update Code:: 20240329
PubMed Central ID:: PMC7547728
DOI:: 10.1038/s41598-020-73670-4
PMID:: 33037249
: Czasopismo naukowe

Pełny tekst

The high fat diet alters intestinal microbiota due to increased intestinal permeability and susceptibility to microbial antigens leads to metabolic endotoxemia. But probiotic juices reported for various health benefits. In this background we hypothesized that pectinase treated probiotic banana juice has diverse effects on HFD induced obesity and non-alcoholic steatohepatitis. 20 weeks fed HFD successfully induced obesity and its associated complications in experimental rats. The supplementation of probiotic banana juice for 5 months at a dose of 5 mL/kg bw/day resulted significant decrease (p < 0.05) in body weight (380 ± 0.34), total fat (72 ± 0.8), fat percentage (17 ± 0.07) and fat free mass (165 ± 0.02). Reduction (p < 0.05) in insulin resistance (5.20 ± 0.03), lipid profile (TC 120 ± 0.05; TG 160 ± 0.24; HDL 38 ± 0.03), liver lipid peroxidation (0.7 ± 0.01), hepatic enzyme markers (AST 82 ± 0.06; ALT 78 ± 0.34; ALP 42 ± 0.22), and hepatic steatosis by increasing liver antioxidant potential (CAT 1.4 ± 0.30; GSH 1.04 ± 0.04; SOD 0.82 ± 0.22) with normal hepatic triglycerides (15 ± 0.02) and glycogen (0.022 ± 0.15) contents and also showed normal liver size, less accumulation of lipid droplets with only a few congestion. It is concluded that the increased intestinal S. cerevisiae yeast can switch anti-obesity, antidiabetic, antioxidative stress, antioxidant and anti-hepatosteatosis effect. This study results will have significant implications for treatment of NAFLD.

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