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Tytuł:
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Meroterpenoids with diverse structures and anti-inflammatory activities from Rhododendron anthopogonoides.
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Autorzy:
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Shi Q; School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 201203, China.
Li TT; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Wu YM; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Sun XY; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Lei C; School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 201203, China.
Li JY; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: .
Hou AJ; School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 201203, China. Electronic address: .
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Źródło:
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Phytochemistry [Phytochemistry] 2020 Dec; Vol. 180, pp. 112524. Date of Electronic Publication: 2020 Oct 07.
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Typ publikacji:
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Journal Article
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Język:
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English
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Imprint Name(s):
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Publication: 2003- : London : Elsevier
Original Publication: 1961-2003: Oxford : Pergamon Press.
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MeSH Terms:
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Rhododendron*
Anti-Inflammatory Agents/pharmacology ; Crystallography, X-Ray ; Diterpenes ; Stereoisomerism
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Contributed Indexing:
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Keywords: Anthoponoids A−I; Anti-inflammation; Daurichromene D; Ericaceae; Meroterpenoids; Rhododendron anthopogonoides Maxim.
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Substance Nomenclature:
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0 (Anti-Inflammatory Agents)
0 (Diterpenes)
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Entry Date(s):
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Date Created: 20201010 Date Completed: 20201123 Latest Revision: 20201123
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Update Code:
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20240105
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DOI:
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10.1016/j.phytochem.2020.112524
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PMID:
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33038550
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Eight pairs of meroterpenoid enantiomers and four achiral meroterpenoids were isolated from Rhododendron anthopogonoides Maxim. Seventeen of them, named (+)-/(-)-anthoponoids A-G, (+)-daurichromene D, and anthoponoids H and I, are undescribed compounds with structural diversity. Their structures were characterized herein by a combined application of spectroscopic techniques, X-ray crystallographic analysis, ECD calculation, and the modified Mosher's method. (+)-/(-)-Anthoponoid A and anthoponoid I are the first Rhododendron meroterpenoids found to possess a hexahydroxanthene motif and a diterpene unit, respectively. Some isolates were identified as NF-κB pathway inhibitors, and (+)-anthoponoid E, (-)-anthoponoid G, and anthoponoid H showed suppressive effects on LPS-induced inflammatory responses in RAW 264.7 macrophages.
(Copyright © 2020 Elsevier Ltd. All rights reserved.)
