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Tytuł pozycji:

Prognostic value of PSMA, c-MET and E-cadherin in salivary duct carcinoma.

Tytuł :
Prognostic value of PSMA, c-MET and E-cadherin in salivary duct carcinoma.
Autorzy :
van Boxtel W; Department of Medical Oncology, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, the Netherlands.
Uijen MJM; Department of Medical Oncology, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, the Netherlands.
Verhaegh GW; Department of Urology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, the Netherlands.
Willems SM; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, the Netherlands.
Jonker MA; Department of Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Schalken JA; Department of Urology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, the Netherlands.
van Engen-van Grunsven ICH; Department of Pathology, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, the Netherlands.
van Herpen CML; Department of Medical Oncology, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, the Netherlands. Electronic address: .
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Corporate Authors :
PALGA Group
Źródło :
Oral oncology [Oral Oncol] 2020 Nov; Vol. 110, pp. 105018. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
Język :
English
Imprint Name(s) :
Publication: Amsterdam : Elsevier
Original Publication: Oxford ; New York : Pergamon, c1997-
Contributed Indexing :
Keywords: Cadherins*; E-cadherin*; Genes, erbB-2*; HER-2*; PSMA*; Prognosis*; Proto-Oncogene Proteins c-met*; Receptors, Androgen*; Salivary Gland Neoplasms*; Survival analysis*
Entry Date(s) :
Date Created: 20201011 Latest Revision: 20201123
Update Code :
20210210
DOI :
10.1016/j.oraloncology.2020.105018
PMID :
33039794
Czasopismo naukowe
Objectives: Salivary duct carcinoma (SDC) is a rare and aggressive subtype of salivary gland cancer. Androgen receptor (AR) (96%) and HER2 (29-46%) expression, and a high propensity for regional lymph node metastases are hallmarks of the disease. We hypothesized that c-MET, E-cadherin, PSMA tumor and PSMA neovascular expression may be prognostic factors in SDC.
Materials and Methods: Expression levels of these proteins were established on tissue microarrays containing 165 primary SDC tumor specimens. Association with survival was studied with Kaplan-Meier curves, and univariable and multivariable Cox regression models. Furthermore, association with lymph node status, AR and HER2 expression, and gender was studied.
Results: We found that patients with high PSMA tumor expression showed a significantly longer overall survival (OS) (median 83 vs. 43 months, P = 0.022), a trend towards a longer DFS (median 51 vs. 22 months, P = 0.094), and significantly reduced hazard ratio for death in the univariable Cox regression model (HR 0.46, P = 0.034). In the multivariable model only a high number of tumor-positive lymph nodes and high age (>80) at diagnosis were prognostic for poor OS. High PSMA tumor expression was also significantly associated with low N-stage (P = 0.001) and expression was higher in women versus men (P = 0.029). High PSMA tumor expression and E-cadherin loss were significantly associated with strong and weak AR-expression, respectively (P = 0.033 and P = 0.007). None of the factors were significantly associated with HER2 expression.
Conclusion: c-MET, E-cadherin, and tumor and neovascular PSMA expression are no independent prognostic factors in SDC.
(Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)

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