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Title:
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Prognostic value of PSMA, c-MET and E-cadherin in salivary duct carcinoma.
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Authors:
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van Boxtel W; Department of Medical Oncology, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, the Netherlands.
Uijen MJM; Department of Medical Oncology, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, the Netherlands.
Verhaegh GW; Department of Urology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, the Netherlands.
Willems SM; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, the Netherlands.
Jonker MA; Department of Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Schalken JA; Department of Urology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, the Netherlands.
van Engen-van Grunsven ICH; Department of Pathology, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, the Netherlands.
van Herpen CML; Department of Medical Oncology, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, the Netherlands. Electronic address: .
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Corporate Authors:
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PALGA Group
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Source:
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Oral oncology [Oral Oncol] 2020 Nov; Vol. 110, pp. 105018. Date of Electronic Publication: 2020 Oct 08.
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Publication Type:
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Journal Article
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Language:
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English
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Imprint Name(s):
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Publication: Amsterdam : Elsevier
Original Publication: Oxford ; New York : Pergamon, c1997-
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MeSH Terms:
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Cadherins/*genetics
Carcinoma, Ductal/*etiology
Proteasome Endopeptidase Complex/*metabolism
Proto-Oncogene Proteins c-met/*genetics
Salivary Gland Neoplasms/*etiology
Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor ; Cadherins/metabolism ; Carcinoma, Ductal/diagnosis ; Carcinoma, Ductal/mortality ; Carcinoma, Ductal/therapy ; Disease Susceptibility ; Female ; Gene Expression ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Prognosis ; Proportional Hazards Models ; Proto-Oncogene Mas ; Proto-Oncogene Proteins c-met/metabolism ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Salivary Gland Neoplasms/diagnosis ; Salivary Gland Neoplasms/mortality ; Salivary Gland Neoplasms/therapy
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Contributed Indexing:
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Keywords: Cadherins; E-cadherin; Genes, erbB-2; HER-2; PSMA; Prognosis; Proto-Oncogene Proteins c-met; Receptors, Androgen; Salivary Gland Neoplasms; Survival analysis
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Substance Nomenclature:
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0 (AR protein, human)
0 (Biomarkers, Tumor)
0 (Cadherins)
0 (MAS1 protein, human)
0 (Proto-Oncogene Mas)
0 (Receptors, Androgen)
EC 2.7.10.1 (MET protein, human)
EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
EC 3.4.25.1 (Proteasome Endopeptidase Complex)
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Entry Date(s):
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Date Created: 20201011 Date Completed: 20210709 Latest Revision: 20211204
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Update Code:
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20240105
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DOI:
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10.1016/j.oraloncology.2020.105018
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PMID:
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33039794
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Objectives: Salivary duct carcinoma (SDC) is a rare and aggressive subtype of salivary gland cancer. Androgen receptor (AR) (96%) and HER2 (29-46%) expression, and a high propensity for regional lymph node metastases are hallmarks of the disease. We hypothesized that c-MET, E-cadherin, PSMA tumor and PSMA neovascular expression may be prognostic factors in SDC.
Materials and Methods: Expression levels of these proteins were established on tissue microarrays containing 165 primary SDC tumor specimens. Association with survival was studied with Kaplan-Meier curves, and univariable and multivariable Cox regression models. Furthermore, association with lymph node status, AR and HER2 expression, and gender was studied.
Results: We found that patients with high PSMA tumor expression showed a significantly longer overall survival (OS) (median 83 vs. 43 months, P = 0.022), a trend towards a longer DFS (median 51 vs. 22 months, P = 0.094), and significantly reduced hazard ratio for death in the univariable Cox regression model (HR 0.46, P = 0.034). In the multivariable model only a high number of tumor-positive lymph nodes and high age (>80) at diagnosis were prognostic for poor OS. High PSMA tumor expression was also significantly associated with low N-stage (P = 0.001) and expression was higher in women versus men (P = 0.029). High PSMA tumor expression and E-cadherin loss were significantly associated with strong and weak AR-expression, respectively (P = 0.033 and P = 0.007). None of the factors were significantly associated with HER2 expression.
Conclusion: c-MET, E-cadherin, and tumor and neovascular PSMA expression are no independent prognostic factors in SDC.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)
