Nucleus accumbens cytoarchitecture predicts weight gain in children.

Szczegóły
Abstrakt

Tytuł:: Nucleus accumbens cytoarchitecture predicts weight gain in children.
Autorzy:: Rapuano KM; Department of Psychology, Yale University, New Haven, CT 06511.
Laurent JS; College of Nursing and Health Sciences, University of Vermont, Burlington, VT 05405.
Hagler DJ Jr; Department of Radiology, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA 92093.
Hatton SN; Department of Neurosciences, University of California San Diego, La Jolla, CA 92093.
Thompson WK; Division of Biostatistics, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA 92093.
Jernigan TL; Department of Cognitive Science, University of California San Diego, La Jolla, CA 92093.; Center for Human Development, University of California San Diego, La Jolla, CA 92093.
Dale AM; Department of Radiology, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA 92093.; Department of Neurosciences, University of California San Diego, La Jolla, CA 92093.
Casey BJ; Department of Psychology, Yale University, New Haven, CT 06511.
Watts R; Department of Psychology, Yale University, New Haven, CT 06511; .
Źródło:: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 27; Vol. 117 (43), pp. 26977-26984. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
Język:: English
Imprint Name(s):: Original Publication: Washington, DC : National Academy of Sciences
MeSH Terms:: Waist Circumference*
Weight Gain*
Nucleus Accumbens/*cytology
Pediatric Obesity/*etiology
Cell Count ; Child ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Male ; Nucleus Accumbens/diagnostic imaging ; Pediatric Obesity/diagnostic imaging
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Grant Information:: U24 DA041147 United States DA NIDA NIH HHS; U01 DA051039 United States DA NIDA NIH HHS; U01 DA041120 United States DA NIDA NIH HHS; U01 DA051018 United States DA NIDA NIH HHS; U01 DA041093 United States DA NIDA NIH HHS; U24 DA041123 United States DA NIDA NIH HHS; U01 DA051038 United States DA NIDA NIH HHS; U01 DA051037 United States DA NIDA NIH HHS; U01 DA051016 United States DA NIDA NIH HHS; U01 DA041106 United States DA NIDA NIH HHS; U01 DA041117 United States DA NIDA NIH HHS; U01 DA041148 United States DA NIDA NIH HHS; U01 DA041174 United States DA NIDA NIH HHS; U01 DA041134 United States DA NIDA NIH HHS; U01 DA041022 United States DA NIDA NIH HHS; U01 DA041156 United States DA NIDA NIH HHS; U01 DA050987 United States DA NIDA NIH HHS; U01 DA041025 United States DA NIDA NIH HHS; U01 DA050989 United States DA NIDA NIH HHS; U01 DA041089 United States DA NIDA NIH HHS; U01 DA050988 United States DA NIDA NIH HHS; U01 DA041028 United States DA NIDA NIH HHS; U01 DA041048 United States DA NIDA NIH HHS
Contributed Indexing:: Keywords: brain development; diffusion MRI; nucleus accumbens; pediatric obesity; restriction spectrum imaging
Entry Date(s):: Date Created: 20201013 Date Completed: 20201217 Latest Revision: 20210317
Update Code:: 20240105
PubMed Central ID:: PMC7604478
DOI:: 10.1073/pnas.2007918117
PMID:: 33046629
: Czasopismo naukowe

The prevalence of obesity in children and adolescents worldwide has quadrupled since 1975 and is a key predictor of obesity later in life. Previous work has consistently observed relationships between macroscale measures of reward-related brain regions (e.g., the nucleus accumbens [NAcc]) and unhealthy eating behaviors and outcomes; however, the mechanisms underlying these associations remain unclear. Recent work has highlighted a potential role of neuroinflammation in the NAcc in animal models of diet-induced obesity. Here, we leverage a diffusion MRI technique, restriction spectrum imaging, to probe the microstructure (cellular density) of subcortical brain regions. More specifically, we test the hypothesis that the cell density of reward-related regions is associated with obesity-related metrics and early weight gain. In a large cohort of nine- and ten-year-olds enrolled in the Adolescent Brain Cognitive Development (ABCD) study, we demonstrate that cellular density in the NAcc is related to individual differences in waist circumference at baseline and is predictive of increases in waist circumference after 1 y. These findings suggest a neurobiological mechanism for pediatric obesity consistent with rodent work showing that high saturated fat diets increase gliosis and neuroinflammation in reward-related brain regions, which in turn lead to further unhealthy eating and obesity.
Competing Interests: Competing interest statement: A.M.D. is a founder of, and holds equity in, CorTechs Labs, Inc. and serves on its Scientific Advisory Board. He is a member of the Scientific Advisory Board of Human Longevity, Inc. and receives funding through research grants with General Electric Healthcare. The terms of these arrangements have been reviewed by and approved by the University of California, San Diego in accordance with its conflict of interest policies.
(Copyright © 2020 the Author(s). Published by PNAS.)

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