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Tytuł:
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Intraoperative 99mTc-MIBI-Guided Parathyroidectomy Improves Curative Effect of Parathyroidectomy, Bone Metabolism, and Bone Mineral Density.
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Autorzy:
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Chen J; 56694 Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Feng J; 56694 Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zhou Q; 56694 Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Zheng W; 56694 Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Meng X; 56694 Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Wang Y; 56694 Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Wang J; 56694 Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
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Źródło:
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The American surgeon [Am Surg] 2021 Mar; Vol. 87 (3), pp. 463-472. Date of Electronic Publication: 2020 Oct 13.
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Typ publikacji:
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Journal Article; Randomized Controlled Trial
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Język:
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English
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Imprint Name(s):
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Publication: 2020- : [Thousand Oaks, CA] : SAGE Publications in association with Southeastern Surgical Congress
Original Publication: Atlanta Ga : Southeastern Surgical Congress
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MeSH Terms:
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Bone Density*
Bone Remodeling*
Radiopharmaceuticals*
Technetium Tc 99m Sestamibi*
Hyperparathyroidism, Secondary/*surgery
Parathyroidectomy/*methods
Surgery, Computer-Assisted/*methods
Adult ; Aged ; Biomarkers/blood ; Female ; Follow-Up Studies ; Forearm/surgery ; Free Tissue Flaps/transplantation ; Humans ; Hyperparathyroidism, Secondary/blood ; Hyperparathyroidism, Secondary/diagnostic imaging ; Male ; Middle Aged ; Radionuclide Imaging ; Treatment Outcome
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Contributed Indexing:
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Keywords: 99mTc-MIBI-guided parathyroidectomy; blood calcium; bone metabolism; bone mineral density; secondary hyperparathyroidism
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Substance Nomenclature:
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0 (Biomarkers)
0 (Radiopharmaceuticals)
971Z4W1S09 (Technetium Tc 99m Sestamibi)
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Entry Date(s):
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Date Created: 20201013 Date Completed: 20210415 Latest Revision: 20210415
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Update Code:
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20240105
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DOI:
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10.1177/0003134820951467
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PMID:
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33047971
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This study aimed to compare the postoperative effects of total parathyroidectomy plus forearm transplantation and radioguided parathyroidectomy on bone metabolism and bone mineral density (BMD). From June 2013 to October 2017, 67 patients with renal secondary hyperparathyroidism (SHPT) received surgical treatment. The control group included 30 cases of classical total parathyroidectomy plus forearm transplantation for SHPT. In the experimental group, 37 patients underwent 99mTc-MIBI-guided parathyroidectomy. Demographics, parathyroid hormone (PTH) level, blood calcium level, and pathological results were compared between the 2 groups. The curative effect of parathyroidectomy and its effect on BMD were also compared. The BMDs in the L1-L4 segments and femoral neck in both groups were significantly improved after operation (all P < .05). The T scores of the L1-L4 segments and femoral neck in both groups were significantly improved after operation (all P < .05). The improvement in the T score of the L4 in the experimental group was significantly higher than that in the control group ( P < .05). No significant differences in the improvement in the L1-L3 segments and femoral neck were found between the 2 groups. Both traditional total parathyroidectomy plus forearm transplantation and 99mTc-MIBI-guided parathyroidectomy can improve PTH level, blood calcium level, phosphorus level, bone metabolism, and BMD to varying degrees in patients with SHPT. Compared with the traditional surgery, 99mTc-MIBI-guided parathyroidectomy can improve blood calcium and phosphorus metabolisms, reduce PTH level, and improve the T scores of L4 to a greater extent.
