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Tytuł:
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Cardioprotective Effect of Anesthetics: Translating Science to Practice.
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Autorzy:
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Lin S; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD.
Neelankavil J; Department of Anesthesiology and Perioperative Medicine, Division of Cardiothoracic Anesthesiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA.
Wang Y; Department of Anesthesiology, Physiology and Medicine, Division of Molecular Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA. Electronic address: .
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Źródło:
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Journal of cardiothoracic and vascular anesthesia [J Cardiothorac Vasc Anesth] 2021 Mar; Vol. 35 (3), pp. 730-740. Date of Electronic Publication: 2020 Sep 20.
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Typ publikacji:
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Journal Article; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Philadelphia, PA : W.B. Saunders, c1991-
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MeSH Terms:
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Anesthetics, Inhalation*
Cardiac Surgical Procedures*
Aged ; Anesthetics, Intravenous ; Humans
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Contributed Indexing:
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Keywords: anesthetics; cardioprotection; clinical trials
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Substance Nomenclature:
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0 (Anesthetics, Inhalation)
0 (Anesthetics, Intravenous)
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Entry Date(s):
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Date Created: 20201014 Date Completed: 20210519 Latest Revision: 20211022
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Update Code:
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20240105
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DOI:
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10.1053/j.jvca.2020.09.113
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PMID:
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33051149
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Cardiovascular diseases are the number one cause of mortality in the world, particularly among the aging population. Major adverse cardiac events are also a major contributor to perioperative complications, affecting 2.6% of noncardiac surgeries and up to 18% of cardiac surgeries. Cardioprotective effects of volatile anesthetics and certain intravenous anesthetics have been well-documented in preclinical studies; however, their clinical application has yielded conflicting results in terms of their efficacy. Therefore, better understanding of the underlying mechanisms and developing effective ways to translate these insights into clinical practice remain significant challenges and unmet needs in the area. Several recent reviews have focused on mechanistic dissection of anesthetic-mediated cardioprotection. The present review focuses on recent clinical trials investigating the cardioprotective effects of anesthetics in the past five years. In addition to highlighting the main outcomes of these trials, the authors provide their perspectives about the current gap in the field and potential directions for future investigations.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
Comment in: J Cardiothorac Vasc Anesth. 2021 Nov;35(11):3450-3451. (PMID: 33781667)
