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Tytuł:
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Can myocardial work indices contribute to the exploration of patients with cardiac amyloidosis?
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Autorzy:
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Roger-Rollé A; Cardiology, Rangueil University Hospital, Toulouse, France.; Cardiac Imaging Center, University Hospital of Toulouse, Toulouse, France.
Cariou E; Cardiology, Rangueil University Hospital, Toulouse, France.; Cardiac Imaging Center, University Hospital of Toulouse, Toulouse, France.
Rguez K; Cardiology, Rangueil University Hospital, Toulouse, France.; Cardiac Imaging Center, University Hospital of Toulouse, Toulouse, France.
Fournier P; Cardiology, Rangueil University Hospital, Toulouse, France.; Cardiac Imaging Center, University Hospital of Toulouse, Toulouse, France.
Lavie-Badie Y; Cardiology, Rangueil University Hospital, Toulouse, France.; Cardiac Imaging Center, University Hospital of Toulouse, Toulouse, France.; Department of Nuclear Medicine, University Hospital of Toulouse, Toulouse, France.
Blanchard V; Cardiology, Rangueil University Hospital, Toulouse, France.; Cardiac Imaging Center, University Hospital of Toulouse, Toulouse, France.; Department of Nuclear Medicine, University Hospital of Toulouse, Toulouse, France.; Medical School, Toulouse III Paul Sabatier University, Toulouse, France.
Roncalli J; Cardiology, Rangueil University Hospital, Toulouse, France.; Medical School, Toulouse III Paul Sabatier University, Toulouse, France.
Galinier M; Cardiology, Rangueil University Hospital, Toulouse, France.; Cardiac Imaging Center, University Hospital of Toulouse, Toulouse, France.; Medical School, Toulouse III Paul Sabatier University, Toulouse, France.
Carrié D; Cardiology, Rangueil University Hospital, Toulouse, France.; Cardiac Imaging Center, University Hospital of Toulouse, Toulouse, France.; Medical School, Toulouse III Paul Sabatier University, Toulouse, France.
Lairez O; Cardiology, Rangueil University Hospital, Toulouse, France .; Cardiac Imaging Center, University Hospital of Toulouse, Toulouse, France.; Department of Nuclear Medicine, University Hospital of Toulouse, Toulouse, France.; Medical School, Toulouse III Paul Sabatier University, Toulouse, France.
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Corporate Authors:
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Toulouse Amyloidosis Research Network collaborators
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Źródło:
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Open heart [Open Heart] 2020 Oct; Vol. 7 (2).
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Typ publikacji:
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Comparative Study; Journal Article
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Język:
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English
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Imprint Name(s):
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Original Publication: [London] : BMJ Publishing Group
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MeSH Terms:
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Echocardiography, Doppler*
Echocardiography, Stress*
Exercise Test*
Myocardial Contraction*
Stroke Volume*
Ventricular Function, Left*
Amyloidosis/*diagnostic imaging
Cardiomyopathies/*diagnostic imaging
Aged ; Aged, 80 and over ; Amyloidosis/mortality ; Amyloidosis/physiopathology ; Cardiomyopathies/mortality ; Cardiomyopathies/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Observer Variation ; Predictive Value of Tests ; Prognosis ; Reproducibility of Results ; Retrospective Studies
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References:
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Contributed Indexing:
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Keywords: echocardiography; heart failure with preserved ejection fraction; restrictive cardiomyopathy
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Entry Date(s):
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Date Created: 20201014 Date Completed: 20201222 Latest Revision: 20201222
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Update Code:
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20240105
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PubMed Central ID:
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PMC7555098
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DOI:
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10.1136/openhrt-2020-001346
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PMID:
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33051335
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Background: Cardiac amyloidosis (CA) is a life-threatening restrictive cardiomyopathy. Identifying patients with a poor prognosis is essential to ensure appropriate care. The aim of this study was to compare myocardial work (MW) indices with standard echocardiographic parameters in predicting mortality among patients with CA.
Methods: Clinical, biological and transthoracic echocardiographic parameters were retrospectively compared among 118 patients with CA. Global work index (GWI) was calculated as the area of left ventricular pressure-strain loop. Global work efficiency (GWE) was defined as percentage ratio of constructive work to sum of constructive and wasted works. Sixty-one (52%) patients performed a cardiopulmonary exercise.
Results: GWI, GWE, global longitudinal strain (GLS), left ventricular ejection fraction (LVEF) and myocardial contraction fraction (MCF) were correlated with N-terminal prohormone brain natriuretic peptide (R=-0.518, R=-0.383, R=-0.553, R=-0.382 and R=-0.336, respectively; p<0.001). GWI and GLS were correlated with peak oxygen consumption (R=0.359 and R=0.313, respectively; p<0.05). Twenty-eight (24%) patients died during a median follow-up of 11 (4-19) months. The best cut-off values to predict all-cause mortality for GWI, GWE, GLS, LVEF and MCF were 937 mm Hg/%, 89%, 10%, 52% and 15%, respectively. The area under the receiver operator characteristic curve of GWE, GLS, GWI, LVEF and MCF were 0.689, 0.631, 0.626, 0.511 and 0.504, respectively.
Conclusion: In CA population, MW indices are well correlated with known prognosis markers and are better than LVEF and MCF in predicting mortality. However, MW does not perform better than GLS.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
