StreptomeDB 3.0: an updated compendium of streptomycetes natural products.

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Tytuł:: StreptomeDB 3.0: an updated compendium of streptomycetes natural products.
Autorzy:: Moumbock AFA; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Straße 9, D-79104 Freiburg, Germany.
Gao M; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Straße 9, D-79104 Freiburg, Germany.
Qaseem A; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Straße 9, D-79104 Freiburg, Germany.
Li J; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Straße 9, D-79104 Freiburg, Germany.
Kirchner PA; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Straße 9, D-79104 Freiburg, Germany.
Ndingkokhar B; Department of Organic Chemistry, University of Yaoundé I, P. O. Box 812, Yaoundé, Cameroon.
Bekono BD; Department of Physics, Higher Teacher Training College, University of Yaoundé I, P. O. Box 47, Yaoundé, Cameroon.
Simoben CV; Department of Pharmaceutical Chemistry, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck Straße 4, D-06120 Halle (Saale), Germany.
Babiaka SB; Department of Chemistry, University of Buea, P. O. Box 63, Buea, Cameroon.
Malange YI; Department of Chemistry, University of Buea, P. O. Box 63, Buea, Cameroon.
Sauter F; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Straße 9, D-79104 Freiburg, Germany.
Zierep P; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Straße 9, D-79104 Freiburg, Germany.
Ntie-Kang F; Department of Pharmaceutical Chemistry, Martin-Luther-Universität Halle-Wittenberg, Wolfgang-Langenbeck Straße 4, D-06120 Halle (Saale), Germany.; Department of Chemistry, University of Buea, P. O. Box 63, Buea, Cameroon.; Institute of Botany, Technische Universität Dresden, Zellescher Weg 20b, D-01217 Dresden, Germany.
Günther S; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Straße 9, D-79104 Freiburg, Germany.
Źródło:: Nucleic acids research [Nucleic Acids Res] 2021 Jan 08; Vol. 49 (D1), pp. D600-D604.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
MeSH Terms:: Databases, Chemical*
Biological Products/*chemistry
Streptomyces/*metabolism
Anti-Bacterial Agents/chemistry
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Substance Nomenclature:: 0 (Anti-Bacterial Agents)
0 (Biological Products)
Entry Date(s):: Date Created: 20201014 Date Completed: 20210126 Latest Revision: 20240330
Update Code:: 20240330
PubMed Central ID:: PMC7779017
DOI:: 10.1093/nar/gkaa868
PMID:: 33051671
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Antimicrobial resistance is an emerging global health threat necessitating the rapid development of novel antimicrobials. Remarkably, the vast majority of currently available antibiotics are natural products (NPs) isolated from streptomycetes, soil-dwelling bacteria of the genus Streptomyces. However, there is still a huge reservoir of streptomycetes NPs which remains pharmaceutically untapped and a compendium thereof could serve as a source of inspiration for the rational design of novel antibiotics. Initially released in 2012, StreptomeDB (http://www.pharmbioinf.uni-freiburg.de/streptomedb) is the first and only public online database that enables the interactive phylogenetic exploration of streptomycetes and their isolated or mutasynthesized NPs. In this third release, there are substantial improvements over its forerunners, especially in terms of data content. For instance, about 2500 unique NPs were newly annotated through manual curation of about 1300 PubMed-indexed articles, published in the last five years since the second release. To increase interoperability, StreptomeDB entries were hyperlinked to several spectral, (bio)chemical and chemical vendor databases, and also to a genome-based NP prediction server. Moreover, predicted pharmacokinetic and toxicity profiles were added. Lastly, some recent real-world use cases of StreptomeDB are highlighted, to illustrate its applicability in life sciences.
(© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.)

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