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Tytuł pozycji:

The distribution of four missense mutations in SPTBN5 gene across native Chinese breeds.

Tytuł:
The distribution of four missense mutations in SPTBN5 gene across native Chinese breeds.
Autorzy:
Zhou H; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
Huang B; Yunnan Academy of Grassland Animal Science, Kunming, China.
Qu K; Yunnan Academy of Grassland Animal Science, Kunming, China.
Liu J; Yunnan Academy of Grassland Animal Science, Kunming, China.
Zhang J; Yunnan Academy of Grassland Animal Science, Kunming, China.
Lei C; College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Źródło:
Animal biotechnology [Anim Biotechnol] 2022 Aug; Vol. 33 (4), pp. 796-800. Date of Electronic Publication: 2020 Oct 16.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Publication: 2005- : Abingdon, Oxford : Taylor & Francis
Original Publication: New York, N.Y. : Marcel Dekker, c1990-
MeSH Terms:
Cattle*/genetics
Mutation, Missense*
Polymorphism, Single Nucleotide*
Alleles ; Animals ; Gene Frequency
Contributed Indexing:
Keywords: Hearing; candidate gene; indicine cattle
Entry Date(s):
Date Created: 20201016 Date Completed: 20220802 Latest Revision: 20221003
Update Code:
20240105
DOI:
10.1080/10495398.2020.1831521
PMID:
33063596
Czasopismo naukowe
Modern cattle belong to two subspecies, Bos taurus and Bos indicus . Since divergence, cattle types have accumulated different genetic variations, which have contributed to highly differentiated phenotypes. The mammalian inner ear possesses functional and morphological innovations that contribute to its unique hearing capacities. The spectrin beta, non-erythrocytic 5 ( SPTBN5 ) gene has been shown to play an important function in the inner ear. Four missense mutations: rs522333459 (c.7232G > C:p.Cys2411Ser), rs718838405 (c.6568A > C:p.Met2190Leu), rs516536785 (c.6283C > T:p.Leu2095Phe) and rs480278206 (c.4201T > C:p.Cys1401Arg) were identified in the bovine SPTBN5 gene by whole genome resequencing (http://animal.nwsuaf.edu.cn/code/index.php/BosVar), which might be candidate mutations related with hearing of both taurine and indicine cattle. In our study, PCR and DNA sequencing were used to explore the allele frequencies of four mutations of 971 individuals belonging to 38 native Chinese cattle breeds. We find that four mutant alleles showing strong geographic distribution, consisting with the ancestry distribution of taurine and indicine in China. In addition, we identified four mutations of SPTBN5 were diverged in taurine and indicine cattle showing signatures of adaptive evolution in two subspecies, which might participate in bovine inner ear development.
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