How irritant are n-propanol and isopropanol? - A systematic review. - OpacWWW

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Abstrakt

Tytuł:: How irritant are n-propanol and isopropanol? - A systematic review.
Autorzy:: Tasar R; Department of Dermatology, University Hospital Jena, Jena, Germany.
Wiegand C; Department of Dermatology, University Hospital Jena, Jena, Germany.
Elsner P; Department of Dermatology, University Hospital Jena, Jena, Germany.
Źródło:: Contact dermatitis [Contact Dermatitis] 2021 Jan; Vol. 84 (1), pp. 1-14. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji:: Journal Article; Systematic Review
Język:: English
Imprint Name(s):: Publication: <2005-> : Oxford : Wiley
Original Publication: Copenhagen, Munksgaard.
MeSH Terms:: 1-Propanol/*adverse effects
2-Propanol/*adverse effects
COVID-19/*prevention & control
Dermatitis, Irritant/*etiology
Anti-Infective Agents, Local/adverse effects ; Hand Disinfection/methods ; Humans
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Contributed Indexing:: Keywords: alcohol-based hand rubs; irritant contact dermatitis; n-propanol; skin barrier
Substance Nomenclature:: 0 (Anti-Infective Agents, Local)
96F264O9SV (1-Propanol)
ND2M416302 (2-Propanol)
Entry Date(s):: Date Created: 20201016 Date Completed: 20201222 Latest Revision: 20210110
Update Code:: 20240105
PubMed Central ID:: PMC7675697
DOI:: 10.1111/cod.13722
PMID:: 33063847
: Czasopismo naukowe

Pełny tekst

Background: The use of alcoholic-based hand rubs (ABHRs) is an important tool for hand hygiene, especially in times of the COVID-19 pandemic. Possible irritant effects of ABHR may prevent their use by persons at risk of infection.
Methods: This systematic review is based on a PubMed search of articles published between January 2000 and September 2019 in English and German, and a manual search, related to the irritation potential of alcohol-based disinfectants restricted to n-propanol (1-propanol) and its structural isomer isopropanol (isopropyl alcohol, 2-propanol).
Results: The majority of the included studies show a low irritation potential of n-propanol alone. However, recent studies provide evidence for significant barrier damage effects of repeated exposure to 60% n-propanol in healthy, as well as atopic skin in vivo. The synergistic response of combined irritants, (ie, a combination of n-propanol or isopropanol with detergents such as sodium lauryl sulfate) is greater, compared with a quantitatively identical application of the same irritant alone.
Conclusion: While recent studies indicate a higher risk of skin irritation for n-propanol and isopropanol than reported in the past, this risk still seems to be lower than that for frequent handwashing with detergents, as recommended by some to prevent COVID-19 infections.
(© 2020 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.)

Informacja

How irritant are n-propanol and isopropanol? - A systematic review.