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Tytuł pozycji:

Health state utility values in people living with HTLV-1 and in patients with HAM/TSP: The impact of a neglected disease on the quality of life.

Tytuł:
Health state utility values in people living with HTLV-1 and in patients with HAM/TSP: The impact of a neglected disease on the quality of life.
Autorzy:
Rosadas C; Section of Virology, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Assone T; Faculdade de Medicina / Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil.
Yamashita M; Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Adonis A; National Centre for Human Retrovirology, St. Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Puccioni-Sohler M; Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Santos M; Instituto Nacional de Cardiologia, Núcleo de Avaliação em Tecnologia em Saúde, Rio de Janeiro, Brazil.
Paiva A; Faculdade de Medicina / Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil.; Universidade Federal de Alagoas, Hospital Universitário Prof. Alberto Antunes, Brazil.
Casseb J; Faculdade de Medicina / Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil.
Oliveira ACP; Instituto de Infectologia Emílio Ribas, Universidade de São Paulo, São Paulo, Brazil.
Taylor GP; Section of Virology, Department of Infectious Disease, Imperial College London, London, United Kingdom.; National Centre for Human Retrovirology, St. Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
Źródło:
PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Oct 16; Vol. 14 (10), pp. e0008761. Date of Electronic Publication: 2020 Oct 16 (Print Publication: 2020).
Typ publikacji:
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
Język:
English
Imprint Name(s):
Original Publication: San Francisco, CA : Public Library of Science
MeSH Terms:
Quality of Life*
Carrier State/*psychology
HTLV-I Infections/*psychology
Neglected Diseases/*psychology
Paraparesis, Tropical Spastic/*psychology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brazil/epidemiology ; Carrier State/epidemiology ; Carrier State/virology ; Cross-Sectional Studies ; Female ; HTLV-I Infections/epidemiology ; HTLV-I Infections/virology ; Health Status ; Human T-lymphotropic virus 1/genetics ; Human T-lymphotropic virus 1/physiology ; Humans ; Male ; Middle Aged ; Neglected Diseases/epidemiology ; Neglected Diseases/virology ; Paraparesis, Tropical Spastic/epidemiology ; Paraparesis, Tropical Spastic/virology ; United Kingdom/epidemiology ; Young Adult
References:
Braz J Infect Dis. 2018 Jul - Aug;22(4):288-293. (PMID: 30145198)
Parkinsonism Relat Disord. 2018 Jun;51:73-78. (PMID: 29530725)
Front Microbiol. 2012 Nov 15;3:388. (PMID: 23162541)
Br Med Bull. 2010;96:5-21. (PMID: 21037243)
Braz J Infect Dis. 2016 Nov - Dec;20(6):592-598. (PMID: 27768899)
Arq Neuropsiquiatr. 2011 Apr;69(2A):208-11. (PMID: 21537562)
Rev Neurol (Paris). 2012 Mar;168(3):257-69. (PMID: 22405461)
Arq Neuropsiquiatr. 2016 Apr;74(4):280-6. (PMID: 27096999)
Int Braz J Urol. 2013 Nov-Dec;39(6):861-6. (PMID: 24456778)
PLoS Negl Trop Dis. 2019 May 1;13(5):e0006967. (PMID: 31042700)
Neurol Clin Pract. 2021 Feb;11(1):49-56. (PMID: 33968472)
J Gynecol Obstet Biol Reprod (Paris). 2004 Feb;33(1 Pt 1):14-20. (PMID: 14968050)
J Pain Res. 2019 Jan 07;12:243-253. (PMID: 30662280)
Clin J Pain. 2011 Feb;27(2):131-5. (PMID: 20842011)
Br J Haematol. 2019 Mar;184(6):1040-1043. (PMID: 29676441)
Qual Life Res. 2017 Feb;26(2):349-357. (PMID: 27534773)
Vox Sang. 2019 Jul;114(5):467-477. (PMID: 31131453)
Med Decis Making. 2016 Feb;36(2):253-63. (PMID: 26492896)
PLoS Negl Trop Dis. 2018 Oct 25;12(10):e0006833. (PMID: 30359373)
J Infect Dis. 2006 Sep 1;194(5):552-60. (PMID: 16897651)
Rev Saude Publica. 2017 Nov 13;51(suppl 2):22s. (PMID: 29160458)
Med Care. 2005 Jul;43(7):736-49. (PMID: 15970790)
Int J Epidemiol. 2000 Dec;29(6):1076-84. (PMID: 11101551)
Value Health. 2012 Jul-Aug;15(5):708-15. (PMID: 22867780)
Urology. 2007 May;69(5):813-8. (PMID: 17482910)
Arq Neuropsiquiatr. 2012 Apr;70(4):257-61. (PMID: 22323336)
Braz J Infect Dis. 2011 Nov-Dec;15(6):578-82. (PMID: 22218518)
PLoS Negl Trop Dis. 2009 Nov 24;3(11):e487. (PMID: 19936247)
Med J Aust. 2016 Oct 3;205(7):305-9. (PMID: 27681971)
Transfusion. 1998 Nov-Dec;38(11-12):1056-62. (PMID: 9838938)
Med Decis Making. 2011 Nov-Dec;31(6):800-4. (PMID: 21422468)
Transfusion. 2013 Jan;53(1):60-8. (PMID: 22554308)
Lancet. 2018 May 12;391(10133):1893-1894. (PMID: 29781438)
Braz J Infect Dis. 2016 Sep-Oct;20(5):494-8. (PMID: 27473890)
Braz J Infect Dis. 2019 Jul - Aug;23(4):224-230. (PMID: 31344356)
Int J Cancer. 2000 Aug 15;87(4):534-8. (PMID: 10918194)
Eur J Obstet Gynecol Reprod Biol. 2009 Dec;147(2):230-3. (PMID: 19733955)
Qual Life Res. 2019 Feb;28(2):297-319. (PMID: 30225787)
Qual Life Res. 2012 Nov;21(9):1545-50. (PMID: 22109110)
AIDS Care. 2019 May;31(5):572-581. (PMID: 30727749)
Lancet Infect Dis. 2020 Jan;20(1):133-143. (PMID: 31648940)
Pain. 2018 Aug;159(8):1433-1437. (PMID: 29554019)
Front Microbiol. 2018 Jul 25;9:1651. (PMID: 30090093)
Transfusion. 2012 Mar;52(3):478-88. (PMID: 21880046)
Clinics (Sao Paulo). 2018 Jul 19;73:e243. (PMID: 30043824)
Grant Information:
United Kingdom DH_ Department of Health
Entry Date(s):
Date Created: 20201016 Date Completed: 20210208 Latest Revision: 20231104
Update Code:
20240105
PubMed Central ID:
PMC7592910
DOI:
10.1371/journal.pntd.0008761
PMID:
33064742
Czasopismo naukowe
Background: HTLV-1 is a neglected sexually transmitted infection despite being the cause of disabling neurological disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). There is no treatment for this infection and public health policies are essential to reduce its transmission. However, there are no data to support adequate cost-effective analysis in this field. The aim of this study was to obtain health state utility values for individuals with HAM/TSP and HTLV-1 asymptomatic carriers (AC). The impact of both states on quality of life (QoL) is described and compared to other diseases.
Methods: A cross-sectional observational study of 141 individuals infected with HTLV-1 (79 with HAM/TSP and 62 AC) from three Brazilian states (Rio de Janeiro, São Paulo and Alagoas) and from the United Kingdom. Participants completed a validated general health questionnaire (EQ-5D, Euroqol) from which country specific health state utility values are generated. Clinical and epidemiological data were collated.
Principal Findings: Health state utility value for HAM/TSP was 0.2991. QoL for 130 reported clinical conditions ranges from 0.35 to 0.847. 12% reported their quality of life as worse as death. Low QoL was associated with severity rather than duration of disease with a moderate inverse correlation between QoL and Osame's Motor Disability Score (-0.4933) Patients who are wheelchair dependent had lowest QoL whilst those still walking unaided had the highest. AC also reported impaired QoL (0.7121) compared to general population.
Conclusion: HTLV-1 and its associated neurological disease has a marked impact on QoL. This study provides robust data to support the development of cost-utility analysis of interventions for HTLV-1.
Competing Interests: The authors have declared that no competing interests exist.
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