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Tytuł:
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The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation.
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Autorzy:
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Dzulko M; Department of Toxicology, University Medical Center, 55131 Mainz, Germany.
Pons M; Department of Toxicology, University Medical Center, 55131 Mainz, Germany.
Henke A; Section of Experimental Virology, Institute of Medical Microbiology, Jena University Hospital, Friedrich Schiller University, 07745 Jena, Germany.
Schneider G; Klinik und Poliklinik für Innere Medizin II, Technical University of Munich, 81675 Munich, Germany.
Krämer OH; Department of Toxicology, University Medical Center, 55131 Mainz, Germany. Electronic address: .
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Źródło:
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Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2020 Dec; Vol. 1874 (2), pp. 188453. Date of Electronic Publication: 2020 Oct 15.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't; Review
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Język:
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English
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Imprint Name(s):
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Original Publication: Amsterdam : Elsevier
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MeSH Terms:
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Cell Transformation, Neoplastic/*metabolism
Protein Phosphatase 2/*genetics
Protein Phosphatase 2/*metabolism
Animals ; Apoptosis ; Autophagy ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics ; DNA Repair ; Heart Function Tests ; Humans ; Substrate Specificity
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Contributed Indexing:
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Keywords: Cancer; PP2A; PPP2R3A; PR130; PR72; Signaling
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Substance Nomenclature:
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EC 3.1.3.16 (PPP2R3A protein, human)
EC 3.1.3.16 (Protein Phosphatase 2)
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Entry Date(s):
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Date Created: 20201017 Date Completed: 20210118 Latest Revision: 20210118
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Update Code:
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20240105
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DOI:
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10.1016/j.bbcan.2020.188453
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PMID:
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33068647
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Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase. This enzyme is involved in a plethora of cellular processes, including apoptosis, autophagy, cell proliferation, and DNA repair. Remarkably, PP2A can act as a context-dependent tumor suppressor or promoter. Active PP2A complexes consist of structural (PP2A-A), regulatory (PP2A-B), and catalytic (PP2A-C) subunits. The regulatory subunits define the substrate specificity and the subcellular localization of the holoenzyme. Here we condense the increasing evidence that the PP2A B-type subunit PR130 is a critical regulator of cell identity and oncogenic transformation. We summarize knowledge on the biological functions of PR130 in normal and transformed cells, targets of the PP2A-PR130 complex, and how diverse extra- and intracellular stimuli control the expression and activity of PR130. We additionally review the impact of PP2A-PR130 on cardiac functions, neuronal processes, and anti-viral defense and how this might affect cancer development and therapy.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
