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Tytuł pozycji:

miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease.

Tytuł :
miRNA-1183-targeted regulation of Bcl-2 contributes to the pathogenesis of rheumatic heart disease.
Autorzy :
Li N; Department of Cardiothoracic Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China.; Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Zhu L; Department of Cardiothoracic Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China.
Zhou H; Department of Cardiothoracic Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China.
Zheng D; Department of Cardiothoracic Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China.
Xu G; Department of Cardiothoracic Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China.
Sun L; Department of Cardiothoracic Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China.
Gao J; Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Shao G; Department of Cardiothoracic Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China.
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Źródło :
Bioscience reports [Biosci Rep] 2020 Nov 27; Vol. 40 (11).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
Język :
English
Imprint Name(s) :
Publication: London : Portland Press on behalf of the Biochemical Society
Original Publication: London : The Biochemical Society, c1981-
MeSH Terms :
Apoptosis*
Heart Valves/*metabolism
Leukocytes, Mononuclear/*metabolism
MicroRNAs/*metabolism
Myocytes, Cardiac/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
Rheumatic Heart Disease/*metabolism
3' Untranslated Regions ; Adult ; Binding Sites ; Case-Control Studies ; Female ; Gene Expression Regulation ; Heart Valves/pathology ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Myocytes, Cardiac/pathology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Rheumatic Heart Disease/genetics ; Rheumatic Heart Disease/pathology ; Signal Transduction ; THP-1 Cells
References :
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Contributed Indexing :
Keywords: B cell lymphoma-2 gene*; apoptosis*; miRNA-1183*; rheumatic heart disease*; target gene prediction*
Substance Nomenclature :
0 (3' Untranslated Regions)
0 (BCL2 protein, human)
0 (MIRN1183 microRNA, human)
0 (MicroRNAs)
0 (Proto-Oncogene Proteins c-bcl-2)
Entry Date(s) :
Date Created: 20201019 Date Completed: 20210412 Latest Revision: 20210412
Update Code :
20210413
PubMed Central ID :
PMC7607189
DOI :
10.1042/BSR20201573
PMID :
33073840
Czasopismo naukowe
To determine whether up-regulation of miR-1183 targeting the gene for anti-apoptotic factor, B-cell lymphoma 2 (BCL-2) contributes to apoptosis in patients with rheumatic heart disease (RHD). Peripheral blood samples were isolated for miR-1183 characterization. The function of miRNA-1183 in RHD using miRNA mimic on PBMCs and THP-1 cell models. The binding of miR-1183 and Bcl-2 gene was confirmed by luciferase activity test. We also measured expression levels of BCL-2 in heart valve tissue from patients with RHD using ELISA and immunohistochemistry. In silico analysis and reporter gene assays indicated that miR-1183 directly targets the mRNA encoding BCL-2. It is found that miR-1183 binds directly to the 3'UTR of the BCL-2 mRNA and down-regulates the mRNA and protein levels of BCL-2. Overexpression of miR-1183 in RHD patients and cell lines down-regulated BCL-2 expression and induced apoptosis. With the progression of the disease, the expression of BCL-2 in the heart valve tissue of patients with RHD decreased. MiRNA-1183 is up-regulated in RHD and induces cardiac myocyte apoptosis through direct targeting and suppression of BCL-2, both of which might play important roles in RHD pathogenesis. During the compensatory period of RHD, up-regulated miR-1183 destroyed the balance of apoptosis proteins (Bax and BAK) in Bcl-2 family, enhance the apoptosis cascade reaction and reduce the anti apoptosis effect. The significantly higher expression levels of miR-1183 appear to play distinct roles in RHD pathogenesis by regulation BCL-2, possibly affecting myocardial apoptosis and remodeling in the context of RHD.
(© 2020 The Author(s).)

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