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Tytuł:
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A Nationwide Study about the Dispersal Patterns of the Predominant HIV-1 Subtypes A1 and B in Greece: Inference of the Molecular Transmission Clusters.
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Autorzy:
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Kostaki EG; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Gova M; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Adamis G; 1st Department of Internal Medicine, G. Gennimatas General Hospital, 11527 Athens, Greece.
Xylomenos G; 1st Department of Internal Medicine, G. Gennimatas General Hospital, 11527 Athens, Greece.
Chini M; 3rd Department of Internal Medicine-Infectious Diseases Unit, 'Korgialeneio-Benakeio' Red Cross General Hospital, 11526 Athens, Greece.
Mangafas N; 3rd Department of Internal Medicine-Infectious Diseases Unit, 'Korgialeneio-Benakeio' Red Cross General Hospital, 11526 Athens, Greece.
Lazanas M; 3rd Department of Internal Medicine-Infectious Diseases Unit, 'Korgialeneio-Benakeio' Red Cross General Hospital, 11526 Athens, Greece.
Metallidis S; 1st Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Tsachouridou O; 1st Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.
Papastamopoulos V; 5th Department of Internal Medicine and Infectious Diseases, Evaggelismos General Hospital, 10676 Athens, Greece.
Chatzidimitriou D; National AIDS Reference Centre of Northern Greece, Department of Microbiology, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Kakalou E; 5th Department of Internal Medicine and Infectious Diseases, Evaggelismos General Hospital, 10676 Athens, Greece.
Antoniadou A; 4th Department of Medicine, Attikon General Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Papadopoulos A; 4th Department of Medicine, Attikon General Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Psichogiou M; 1st Department of Medicine, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Basoulis D; 1st Department of Medicine, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Pilalas D; National AIDS Reference Centre of Northern Greece, Department of Microbiology, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Papageorgiou I; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Paraskeva D; Department of Internal Medicine, Tzaneio General Hospital, 18536 Piraeus, Greece.
Chrysos G; Department of Internal Medicine, Tzaneio General Hospital, 18536 Piraeus, Greece.
Paparizos V; HIV/AIDS Unit, A. Syngros Hospital of Dermatology and Venereology, 16121 Athens, Greece.
Kourkounti S; HIV/AIDS Unit, A. Syngros Hospital of Dermatology and Venereology, 16121 Athens, Greece.
Sambatakou H; HIV Unit, 2nd Department of Internal Medicine, Hippokration General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Bolanos V; HIV Unit, 2nd Department of Internal Medicine, Hippokration General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Sipsas NV; Department of Pathophysiology, Laikon General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Lada M; 2nd Department of Internal Medicine, Sismanogleion General Hospital, 15126 Marousi, Greece.
Barbounakis E; Department of Internal Medicine, University Hospital of Heraklion 'PAGNI', Medical School, University of Crete, 71110 Heraklion, Greece.
Kantzilaki E; Department of Internal Medicine, University Hospital of Heraklion 'PAGNI', Medical School, University of Crete, 71110 Heraklion, Greece.
Panagopoulos P; Department of Internal Medicine, University General Hospital, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Petrakis V; Department of Internal Medicine, University General Hospital, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Drimis S; Department of Internal Medicine, Tzaneio General Hospital, 18536 Piraeus, Greece.
Gogos C; Department of Internal Medicine and Infectious Diseases, University Hospital of Patras, 26504 Rio, Greece.
Hatzakis A; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Beloukas A; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool L697BE, UK.; Department of Biomedical Sciences, School of Health Sciences, University of West Attica, 12243 Athens, Greece.
Skoura L; National AIDS Reference Centre of Northern Greece, Department of Microbiology, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Paraskevis D; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
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Źródło:
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Viruses [Viruses] 2020 Oct 19; Vol. 12 (10). Date of Electronic Publication: 2020 Oct 19.
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Typ publikacji:
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Journal Article; Research Support, Non-U.S. Gov't
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Język:
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English
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Imprint Name(s):
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Original Publication: Basel, Switzerland : MDPI
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MeSH Terms:
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Epidemiological Monitoring*
Phylogeny*
HIV Infections/*epidemiology
HIV Infections/*transmission
HIV-1/*classification
Adult ; Cluster Analysis ; DNA, Viral/genetics ; Female ; Genotype ; Greece/epidemiology ; Humans ; Male ; Middle Aged ; Phylogeography ; Prevalence
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Contributed Indexing:
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Keywords: Greece; dispersal patterns; human immunodeficiency virus (HIV); local transmission; molecular epidemiology; phylogenetic analysis; phylogeographic analysis; transmission clusters
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Substance Nomenclature:
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0 (DNA, Viral)
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Entry Date(s):
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Date Created: 20201022 Date Completed: 20210226 Latest Revision: 20210226
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Update Code:
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20240105
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PubMed Central ID:
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PMC7589601
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DOI:
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10.3390/v12101183
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PMID:
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33086773
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Our aim was to investigate the dispersal patterns and parameters associated with local molecular transmission clusters (MTCs) of subtypes A1 and B in Greece (predominant HIV-1 subtypes). The analysis focused on 1751 (28.4%) and 2575 (41.8%) sequences of subtype A1 and B, respectively. Identification of MTCs was based on phylogenetic analysis. The analyses identified 38 MTCs including 2-1518 subtype A1 sequences and 168 MTCs in the range of 2-218 subtype B sequences. The proportion of sequences within MTCs was 93.8% (1642/1751) and 77.0% (1982/2575) for subtype A1 and B, respectively. Transmissions within MTCs for subtype A1 were associated with risk group (Men having Sex with Men vs. heterosexuals, OR = 5.34, p < 0.001) and Greek origin (Greek vs. non-Greek origin, OR = 6.05, p < 0.001) and for subtype B, they were associated with Greek origin (Greek vs. non-Greek origin, OR = 1.57, p = 0.019), younger age (OR = 0.96, p < 0.001), and more recent sampling (time period: 2011-2015 vs. 1999-2005, OR = 3.83, p < 0.001). Our findings about the patterns of across and within country dispersal as well as the parameters associated with transmission within MTCs provide a framework for the application of the study of molecular clusters for HIV prevention.
