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Tytuł pozycji:

The timed up and go test predicts fracture risk in older women independently of clinical risk factors and bone mineral density.

Tytuł:
The timed up and go test predicts fracture risk in older women independently of clinical risk factors and bone mineral density.
Autorzy:
Larsson BAM; Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Johansson L; Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.; Region Västra Götaland, Department of Orthopaedics, Sahlgrenska University Hospital, Mölndal, Sweden.
Johansson H; Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia.
Axelsson KF; Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.; Region Västra Götaland, Department of Orthopaedic Surgery, Skaraborg Hospital, Skövde, Sweden.
Harvey N; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton, UK.
Vandenput L; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia.; Centre for Bone and Arthritis Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Magnusson P; Department of Clinical Chemistry, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
McCloskey E; Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK.; MRC and Arthritis Research UK Centre for Integrated Research in Musculoskeletal Ageing, Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK.
Liu E; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia.
Kanis JA; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia.; Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, UK.
Sundh D; Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Lorentzon M; Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. .; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia. .; Region Västra Götaland, Department of Geriatric Medicine, Sahlgrenska University Hospital, 43180, Mölndal, Sweden. .
Źródło:
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2021 Jan; Vol. 32 (1), pp. 75-84. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji:
Journal Article
Język:
English
Imprint Name(s):
Original Publication: London, UK : Springer International, c1990-
MeSH Terms:
Diabetes Mellitus, Type 2*
Hip Fractures*/epidemiology
Hip Fractures*/etiology
Osteoporotic Fractures*/epidemiology
Osteoporotic Fractures*/etiology
Aged ; Bone Density ; Female ; Humans ; Postural Balance ; Risk Factors ; Task Performance and Analysis ; Time and Motion Studies
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Grant Information:
MC_PC_21001 United Kingdom MRC_ Medical Research Council; MC_PC_21003 United Kingdom MRC_ Medical Research Council; MR/P020941/1 United Kingdom MRC_ Medical Research Council
Contributed Indexing:
Keywords: Clinical risk factors and bone mineral density; Fracture risk; The timed up and go test
Entry Date(s):
Date Created: 20201022 Date Completed: 20210204 Latest Revision: 20220317
Update Code:
20240105
PubMed Central ID:
PMC7755867
DOI:
10.1007/s00198-020-05681-w
PMID:
33089354
Czasopismo naukowe
The timed up and go (TUG) test measures physical performance and predicts falls in the elderly. In older women, TUG time predicts the risk of major osteoporotic fracture and hip fracture independently of clinical risk factors and bone mineral density, and has a substantial impact on fracture probabilities.
Introduction: The timed up and go (TUG) test measures physical performance and predicts falls in the elderly. A slow TUG has been associated with an increased fracture risk, but it is unclear whether the association is independent of clinical risk factors and bone mineral density (BMD). The aim of this study was to investigate if TUG time was associated with fracture risk independently of clinical risk factors and BMD and to determine its impact on fracture probabilities in older women.
Methods: A standardized questionnaire was used to assess information regarding clinical risk factors in the large population-based SUPERB study of 3028 older women (75-80 years). At baseline, the TUG test was performed and BMD measured with DXA. The association between TUG time and the risk of hip fracture and major osteoporotic fracture (MOF) was examined using an extension of Poisson regression.
Results: Fracture incidence increased steeply with increasing TUG time up to 12 s and subsequently started to level off. A slow TUG time was therefore defined as TUG > 12 s, a cutoff level then used in Cox models to study the association between slow TUG and fracture risk. A slow TUG time was associated with an increased risk of fracture (MOF 2.39 [1.80-3.18] and hip fracture 2.96 [1.62-5.40]). These associations were slightly attenuated but remained significant after adjustment for clinical risk factors and femoral neck BMD. Depending on BMD, the 4-year fracture probability of MOF increased by a factor of 1.5-1.9 in a 75-year-old woman with slow TUG (> 12 s).
Conclusion: The TUG time predicts the risk of MOF and hip fracture independently of clinical risk factors and BMD and has a substantial impact on fracture probabilities, indicating that inclusion of the TUG test in patient evaluation should be considered in order to improve fracture prediction in older women.

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