Taurine supplementation, fat absorption, and growth in cystic fibrosis.

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Abstrakt

Tytuł:: Taurine supplementation, fat absorption, and growth in cystic fibrosis.
Autorzy:: Thompson GN; Department of Chemical Pathology, Adelaide Children's Hospital, South Australia.
Robb TA
Davidson GP
Źródło:: The Journal of pediatrics [J Pediatr] 1987 Oct; Vol. 111 (4), pp. 501-6.
Typ publikacji:: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
Język:: English
Imprint Name(s):: Original Publication: St. Louis, MO : Mosby
MeSH Terms:: Growth*
Cystic Fibrosis/*metabolism
Dietary Fats/*metabolism
Taurine/*therapeutic use
Body Height ; Body Weight ; Child ; Child, Preschool ; Clinical Trials as Topic ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/physiopathology ; Double-Blind Method ; Fatty Acids, Essential/metabolism ; Feces/analysis ; Female ; Glycine/metabolism ; Humans ; Intestinal Absorption ; Male ; Taurine/metabolism ; Vitamins/metabolism
Substance Nomenclature:: 0 (Dietary Fats)
0 (Fatty Acids, Essential)
0 (Vitamins)
1EQV5MLY3D (Taurine)
TE7660XO1C (Glycine)
Entry Date(s):: Date Created: 19871001 Date Completed: 19871113 Latest Revision: 20190630
Update Code:: 20240104
DOI:: 10.1016/s0022-3476(87)80108-7
PMID:: 3309233
: Czasopismo naukowe

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The effect of taurine supplementation (30 to 40 mg/kg/24 hr) on fat absorption and related measurements was examined in 21 preadolescent children with cystic fibrosis (CF) using a 12-month double-blind crossover technique. The mean coefficient of fat absorption was unchanged by taurine both in the unselected study group (without taurine, mean +/- SD 84.0% +/- 11.9%; with taurine, 84.4% +/- 11.8%, n = 20) and in a subgroup of seven children with moderately severe fat malabsorption (without taurine, 75.6% +/- 15.6%; with taurine, 74.8% +/- 14.6%). The mean fecal split fat/total fat ratio, which generally reflects bile acid-related fat malabsorption, was also unchanged. Linoleic and arachidonic acid deficiencies noted in plasma before supplementation showed no significant improvement with taurine supplementation. Likewise, plasma/serum vitamin A, E, and D levels were unchanged. Standard scores for height and weight were not affected significantly. This study does not support the use of taurine supplementation in the nutritional management of CF.

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