Actual 10-year survivors and 10-year recurrence free survivors after primary liver resection for hepatocellular carcinoma in the 21st century: A single institution contemporary experience. - OpacWWW

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Tytuł:: Actual 10-year survivors and 10-year recurrence free survivors after primary liver resection for hepatocellular carcinoma in the 21st century: A single institution contemporary experience.
Autorzy:: Linn YL; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore, Singapore.
Chee MY; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore, Singapore.
Koh YX; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore.
Teo JY; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore.
Cheow PC; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore.
Chow PKH; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore.
Chan CY; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore.
Chung AYF; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore.
Ooi LLPJ; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore.
Goh BKP; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore.
Źródło:: Journal of surgical oncology [J Surg Oncol] 2021 Jan; Vol. 123 (1), pp. 214-221. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji:: Clinical Trial; Journal Article
Język:: English
Imprint Name(s):: Publication: <2005-> : Hoboken, NJ : Wiley-Liss
Original Publication: New York, Plenum.
MeSH Terms:: Cancer Survivors/*statistics & numerical data
Carcinoma, Hepatocellular/*mortality
Hepatectomy/*mortality
Liver Neoplasms/*mortality
Liver Transplantation/*mortality
Neoplasm Recurrence, Local/*mortality
Aged ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/surgery ; Female ; Follow-Up Studies ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery ; Prognosis ; Prospective Studies ; Retrospective Studies ; Survival Rate ; Time Factors
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Contributed Indexing:: Keywords: actual survival; hepatocellular carcinoma; outcomes; predictors; prognosis
Entry Date(s):: Date Created: 20201023 Date Completed: 20210111 Latest Revision: 20210111
Update Code:: 20240105
DOI:: 10.1002/jso.26259
PMID:: 33095920
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Background: At present, the majority of outcome studies of survival of hepatocellular carcinoma (HCC) post-liver resection (post-LR) present actuarial survival data, which often results in overestimation of survival. We sought to evaluate the actual 10-year survival post-LR for HCC and identify variables that are associated with long-term survival.
Methods: We performed a retrospective review of 600 consecutive patients who underwent primary LR for HCC from 2000 to 2010 at our institution. Twenty-eight patients (4.7%) with 90-day mortality and 125 patients who were lost to follow-up within 10 years were excluded leaving 447 patients who met the study criteria.
Results: There were 140 actual 10-year survivors of which 57 (40.7%) had a recurrence within 10 years. The actual 10-year overall survival (OS) rate of the 447 patients was 31.5% and the actual 10-year recurrence-free survival (RFS) was 18.6%. Multivariate analyses demonstrated that only age >65 years (OR, 0.29; p < .001) (OR, 0.973; p = .041) and presence of cirrhosis (OR. 0.37; p = .005) (OR, 0.31; p = .001) were independent factors negatively associated with actual 10-year OS and actual 10-year RFS, respectively.
Conclusion: Approximately one-third of patients will survive over 10 years after LR for HCC. Amongst these 10-year survivors, 41% had developed recurrent cancer within 10-years of follow-up.
(© 2020 Wiley Periodicals LLC.)

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Actual 10-year survivors and 10-year recurrence free survivors after primary liver resection for hepatocellular carcinoma in the 21st century: A single institution contemporary experience.